Changes in plasma and erythrocyte chlorpromazine concentrations during sample storage.
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Biomedical subjects
Publications and source records attributed to R W Nysewander.
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Forty inpatients receiving routine treatment for acute mania were rated for severity of psychopathology using a new Mania Rating Scale (MRS). Ratings wer obtained during the first week in hospital and 2 weeks thereafter. A wide range of scores was obtained at both ratings. There were significant decreases between ratings in the frequency of some but not all diagnostic signs and symptoms. Patients with sufficient signs and symptoms for a cross-sectional diagnosis of mania had significantly greater total MRS scores than those with fewer signs and symptoms. The range of overlap in total MRS scores between these groups was noted.
Seventeen patients hospitalized for acute mania were followed up 1 month after discharge. Ratings of psychopathology at discharge using a new Mania Rating Scale differentiated the 12 patients who maintained outpatient status for 1 month from the five who did not. Total scores greater than 14.0 predicted being rehospitalized or jailed. Significantly higher item ratings for speech (rate and amount), language-thought disorder, irritability, and disruptive-aggressive behavior were noted in the poorer compared to the better outcome group.