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R W Pamenter

Publications and source records attributed to R W Pamenter.

23 records · Page 2Linked to original sources

Acetaldehyde acutely impairs canine testicular testosterone secretion.

Utilizing a method for perfusion of the in vivo isolated canine testis we have examined basal and human chorionic gonadotropin (hGC)-stimulated testosterone production of testes acutely exposed to ethanol and acetaldehyde. Ethanol infused at concentrations of 0.2 g/dl to 0.6 g/dl did not alter basal of hCG-stimulated testicular testosterone production of one testis when compared to the saline-infused control testis of the same animal. However, acetaldehyde infused at a concentration of 0.2 mg/dkl, a level similar to that found in humans drinking moderate amounts of ethanol, significantly impaired hCG-stimulated testicular testosterone production. It is concluded that acetaldehyde acutely impairs hCG-stimulated testicular testosterone secretion by a direct effect on the testis, but ethanol does not.

Acetaldehyde↗

High density lipoprotein cholesterol and body composition of female runners.

Twenty-two women participating in an endurance running program had determinations of body composition, of plasma total cholesterol (TC) and HDL cholesterol (HDLC) concentrations before and after increasing their running by 30 miles/wk. Mean total body weight, fat weight and relative body fat showed significant decreases, while mean lean weight significantly increased. Mean HDLC increased 5 mg/dl (p less than 0.01). Although increases of HDLC correlated with increases in lean weight, exercise per se appears to increase HDLC of women.

Adult↗

Chronic ethanol ingestion enhances GnRH-stimulated LH responses of castrated male dogs.

Dogs were given no ethanol, 1.28 g ethanol/kg and 1.92 g ethanol/kg daily for 4 weeks immediately after castration. Plasma LH concentrations, basal and in response to 100 micrograms GnRH, were measured before and at 2 and 4 weeks after castration. Basal LH levels after castration increased significantly (P less than 0.005) within each group but were not significantly different between groups. GnRH-stimulated LH responses were similar before and at 23 weeks after castration, but at 4 weeks the dogs given 1.92 g ethanol/kg had a significantly (P less than 0.05) greater response than did the control dogs. It is concluded that daily ethanol ingestion in the amounts employed in this study does not impair hypothalamic--pituitary function in male dogs.

Animals↗