Epidermolysis bullosa acquisita.
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Biomedical subjects
Publications and source records attributed to R W Pearson.
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Two cases of pemphigus vegetans are presented. One, an example of the Hallopeau type of the disease, was found to have early lesions that simulated eosinophilic spongiosis clinically and histologically. The other had lesions that were largely confined to the oral mucosa and was also considered to be the Hallopeau type of the disease in a limited form. The cases of these two patients were compared with a typical case of eosinophilic spongiosis. All were controlled with dapsone therapy.
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An adult patient with massive abdominal Burkitt's lymphoma developed malignant hyperthermia during exploratory laparotomy. Simultaneously, evidence of tumor lysis appeared. The lethal effect of heat on cancer cells has been amply demonstrated experimentally, and clinical trials of regional and whole-body hyperthermia in various human malignancies have appeared. Lymphomas have not been reported among those tumors studied. Burkitt's lymphoma, a rapidly growing tumor, is likely to respond to hyperthermia, and the evidence reported here should be pursued with controlled clinical trials involving induced hyperthermia in refractory malignant lymphomas.