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Biomedical subjects

R W Prouty

Publications and source records attributed to R W Prouty.

9 recordsLinked to original sources

State institutions: thirty years of depopulation and closure.

Over the past 30 years, a number of social, political, and economic forces have influenced public policy decisions regarding residential services for persons with mental retardation and other developmental disabilities (MR/DD). One of the most striking outcomes of these forces has been a steady decrease of persons with MR/DD residing in state institutions. In this paper we show the changes over the past 30 years in state institutional populations, interstate variability, movement of individuals into and out of state institutions, costs of state institutional care, and state institution closures as a result of social policy.

Deinstitutionalization↗

The forensic science implications of site and temporal influences on postmortem blood-drug concentrations.

The dependence of postmortem blood-drug concentrations on the collection site and on the postmortem interval before specimen collection has been studied. These studies consisted of both sequential sampling from the same collection site at defined time intervals and a comparison of the drug concentrations of postmortem blood simultaneously collected from various sites. A site and time dependence was observed for postmortem blood-drug concentrations. The heart blood-drug concentrations were, in general, significantly higher than those of peripheral specimens. As a result of this phenomenon, the analysis of peripheral blood specimens and solid tissues is often necessary before a definitive interpretation of postmortem toxicological analyses is possible.

Absorption↗

A comparison of postmortem heart blood and femoral blood ethyl alcohol concentrations.

Recent research has indicated that substantial differences may exist between the concentration of organic bases in heart blood specimens and that in peripheral blood specimens. This study was designed to determine the distribution characteristics of ethyl alcohol in postmortem blood. The heart blood/femoral blood ethyl alcohol ratio was determined for 100 cases. In the majority of cases exhibiting alcohol concentration differences greater than 0.02 mg/dL, the specimens were suspect because of their physical appearance, trauma to the decedent in the area of specimen collection, gross differences in hematocrits, or large volume differences in the two specimens. An additional set of experiments was conducted to illustrate that the volume of blood and the amount of sodium fluoride preservative placed in the collection tube can have a substantial effect upon the subsequently measured ethyl alcohol concentration. These factors can adversely affect the observed heart blood/femoral blood alcohol ratio and must be considered when evaluating the distribution characteristics of ethyl alcohol in postmortem specimens.

Blood Specimen Collection↗

Fluoxetine overdose: a case report.

A fatality due to the ingestion of fluoxetine and ethanol is reported. Quantitation of the drug and its active normetabolite was accomplished by gas chromatography with a flame ionization detector. Identification of the compounds was performed by gas chromatography/mass spectrometry. Tissue distribution of fluoxetine and norfluoxetine, as well as analytical details, is presented.

Adult↗

Tissue distribution of methylenedioxymethamphetamine.

Two cases of death involving methylenedioxymethamphetamine (MDMA) are reported; one case is a fatal acute overdose and the other is a drug-related death. The tissue distribution of MDMA is reported in both cases.

3,4-Methylenedioxyamphetamine↗