AN IRRITATIVE HYPOTHESIS CONCERNING THE HYPOTHALAMIC REGULATION OF FOOD INTAKE.
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Biomedical subjects
Publications and source records attributed to R W REYNOLDS.
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Two monkeys were trained to press and hold down a telegraph key in the presence of a red light. Subsequent release of the key in response to a white cross superimposed on the red background was followed by reinforcement. Key release in response to a white circle on the red background was never reinforced. Latencies for the key release response to the reinforced stimulus (cross) were considerably shorter and less variable than those to the unreinforced stimulus (circle).
Rats were observed for the incidence of pulmonary edema after the placement of hypothalamic lesions by radio frequency thermocoagulation or d-c electrolysis. In the animals with electrolytic lesions, 31 percent died with pulmonary edema and marked signs were observed in another 20 percent. Moderate transient signs appeared in only 3.7 percent of the animals with radio-frequency lesions, and there were no deaths attributable to this syndrome in this group. These results suggest that this syndrome is an irritative consequence of the electrolytic lesion process rather than a "release" phenomenon.
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