Editorial series: Disease, medical research, and the American Journal of Clinical Pathology. 2. The three major categories of medical research.
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Biomedical subjects
Publications and source records attributed to R W Sappenfield.
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A nine-cell diagnostic decision matrix is described. This matrix can be viewed dynamically as a model of the diagnostic process. The matrix provides for display of equivocal test results and test results of patients who have ill-defined or incompletely determined disease. The matrix represents an improved model for evaluating diagnostic test protocols. Diagnostic test characteristics related to this model are described. Potential advantages and uses of the model are discussed; among them are possibilities for development of improved diagnostic protocols and improved definitions of disease.
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A process for ranking competing diagnostic protocols for a specific disease is presented. The process incorporates the basic principles of medical decision making, and provides for the consideration of equivocal test results as well as results for patients who have ill-defined or incompletely defined disease. It provides a means for developing an a priori optimization process prior to ranking competing diagnostic algorithms. Methods for transferring ranking information among populations with widely differing disease prevalences are given.
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At Charity Hospital of Louisiana at New Orleans, in 1978, there was considerable underuse of serum creatine kinase and lactate dehydrogenase isoenzymes for the diagnosis of myocardial infarction. Laboratory generation of creatine kinase isoenzyme tests for patients suspected of having had myocardial infarctions was only partially effective in correcting underuse. It unnecessarily generated some overuse. Appropriate modifications of this policy could improve performance. Additional, effective educational efforts are needed to improve reasonable use of laboratory tests. The study uncovered an unexpected problem in the laboratory--in a significant percentage of cases, results of indicated and ordered tests failed to appear in the charts.
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