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Biomedical subjects

R W Turkington

Publications and source records attributed to R W Turkington.

At least 73 records · Page 4Linked to original sources
PubMed1969

Lactose synthetase: progesterone inhibition of the induction of alpha-lactalbumin.

Lactose synthesis in the mammary gland is dependent on the hormonally controlled synthesis of the two protein components of lactose synthetase, alpha-lactalbumin and a galactosyltransferase. Prolactin induces the synthesis of both proteins in mammary gland explants treated with insulin and hydrocortisone, but the induction kinetics cannot account for the asynchronous synthesis of the two proteins that are observed in vivo. Progesterone appears to take part in the control of lactose synthesis and acts to repress the formation of alpha-lactalbumin throughout pregnancy. At parturition, when the concentration of progesterone in the plasma decreases, the rate of alpha-lactalbumin synthesis increases.

Albumins↗
PubMed1968

Hormonal dependence of DNA synthesis in mammary carcinoma cells in vitro.

Explants of C3H-mouse and rat R3230AC mammary carcinomas were cultured on chemically defined medium for study of the effects of the hormonal environment on synthesis of DNA. Synthesis in the more slowly proliferating C3H carcinoma cells is stimulated by insulin and inhibited by estrogenic hormones as in normal mammary epithelial cells. Rat R3230AC mammary carcinoma cells can initiate synthesis of DNA independently of insulin or estrogenic hormones. Autonomous growth with respect to these hormonal controls correlates with rapid proliferation, but it is not an essential characteristic of the neoplastic mammary cell.

Adenocarcinoma↗