Daniel Drake MD (1785-1852): pioneer teacher, author, medical and social entrepreneur of the USA.
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Biomedical subjects
Publications and source records attributed to R W Vilter.
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A 24-year-old man with disseminated herpes zoster, which occurred 9 months after bone marrow transplantation for chronic myeloid leukemia, developed encephalopathy and immobilizing myoclonus after 7 days of vidarabine treatment (10 mg/kg of body weight per day). Only mild hepatic dysfunction was a risk factor for a toxic reaction. After the vidarabine therapy was stopped, the symptoms worsened until treatment with hydration, large doses of chlordiazepoxide, and protective care gave symptomatic relief.
A preleukemic syndrome, mast cell hyperplasia in the bone marrow, and urticaria pigmentosa simultaneously developed in a 76-year-old woman. A year later, the patient died of acute myelomonoblastic leukemia. These associations provide evidence favoring the origin of the tissue mast cell from a bone marrow stem cell.
Bilateral ureteral obstruction from uric acid stones developed in a patient with severe autoimmune hemolytic anemia at a time of hemolytic crisis. She had an underlying lymphoma that was clinically inapparent. Patients with severe autoimmune hemolysis should be considered at risk for complications related to excess uric acid.
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Ascorbic acid in physiological doses is essential for the normal functioning of the human body. Larger doses are required to treat a severe deficiency of vitamin C intake, as in the case of scurvy. Occasionally, massive doses may be required to treat a metabolic defect involving ascorbic acid. There has been some mention of megadose therapy with ascorbic acid for the prevention of colds, the improved healing of wounds and even the treatment of cancer, but no acceptable scientific data have been presented. In fact, in a few instances, such therapy has proved injurious.
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A black youth with peripheral retinal (sea fan) neovascularization had both sarcoidosis and alpha-thalassemia. The possibility that both of these disease entities were responsible for the observed pathology is explored. Most of the pathology present, the stasis, the hypoxia, and the vasoproliferation, is presumed to be due to the sarcoidosis. No definite relationship was established in this case for the alpha-thalassemia, a rare genetic abnormality of hemoglobin production.
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