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Biomedical subjects

R Wüllenweber

Publications and source records attributed to R Wüllenweber.

At least 19 recordsLinked to original sources
PubMed1987

Tissue pO2 of human brain cortex--method, basic results and effects of pentoxifylline.

A polarographic multiwire surface electrode was used for measurement of local oxygen partial pressure (pO2) on human brain cortex during neurosurgical operations. The two major problems encountered in this application of the electrode involved sterility of the equipment and mounting of the electrode. The described method of sterilization does not alter the electrical properties of the electrode. A special mount was designed to allow free three-dimensional placement of the electrode without exerting pressure on the cortex. Basic results of this technique demonstrated that it is possible to distinguish different pO2 distribution patterns displayed in pO2 histograms for various types of brain tumors and edematous brain tissue. In patients with arteriovenous malformations (AVMs) of the brain, an increase of tissue pO2 in cortical areas adjacent to the AVM was the result of extirpation of the lesion. The effect of intravenously administered pentoxifylline was studied during extraintracranial bypass operations in patients with cerebrovascular disease. In 7 patients a consistent shift of the pO2 histograms to the right, i.e., to higher pO2 values, could be demonstrated. Mean pO2 values increased statistically significantly by 16 +/- 7 mmHg as early as ten minutes after infusion of pentoxifylline. The rapid improvement of tissue oxygenation of human brain cortex is thought to be the result of an improvement of microcirculation, for other parameters influencing tissue pO2 showed no significant alterations if any.

Arteries↗
PubMed1987

[Dural angiomas].

The management of arteriovenous malformations confined exclusively to the dura and its duplications (DAVMs) is a challenge. The problems of diagnosis and the possible methods of treatment are discussed on the basis of 23 personal cases. Selective and superselective angiography for the detection of any multipedicular supply from separate arterial systems has proved essential before rational treatment can be instituted. Usually it is not possible to cure DAVMs by embolization alone: the approach now used for the main feeders arising from branches of the internal carotid and vertebral arteries is inadequate. However, it is usually possible to reduce the volume of the shunt flow and the pressure in the draining sinuses. Frequently the success is only temporary and a combined surgical and intravascular procedure is later necessary. In isolated cases, inoperable DAVMs can be transformed to operable ones by first performing embolization.

Cerebral Angiography↗
PubMed1984

[Tolerance of patients with craniocerebral injuries to time and transportation factors].

Primary care of head injuries at the scene of accident is of major importance for the stabilization of vegetative functions. In many cases death is caused by an acute increase of intracranial pressure. Thus prognosis is influenced by complications like arterial intracranial bleedings or brain edema. The decision on the means of transportation depends on the possibilities of early treatment of these complications. In clinical examples time as a factor in the care of head injuries and their complications are demonstrated.

Brain Damage, Chronic↗
PubMed1978

Axial transverse computerized tomography in 73 glioblastomas.

Among 2,600 patients, examined by computerized tomography, 404 had brain tumours, which were gliomas in 150 cases. There were 73 glioblastomas. Examination was performed according to Ambrose's method using an intravenous injection of 1 ml 60% contrast medium per kg body weight. Thus 98% of all gliomas could be demonstrated. Glioblastomas are shown in three different forms: an annular type (55%), a nodular type (18%), and a combined type (27%). Perifocal oedema is found in 88% of glioblastomas. The oedema most frequently belongs to grade II or III. Differentialdiagnosis of gliomas, abscess, metastases and other tumours with central necrosis are discussed.

Astrocytoma↗
PubMed1977

[A computer-tomographical examination of cranial bullet wounds (author's transl)].

The report covers the computer-tomographical examination of six patients with acute cranial bullet injuries and fifteen patients suffering from the sequels of such injuries. The diagnostic and prognostic significance of this method of examination in the case of acute injuries is described. The extent of cerebral defects in the case of sequels can be documented during this process by means of x-ray. The computer-tomography therefore offers an objective basis for the assessment of this type of sequela.

Adolescent↗
PubMed1976

[Differential diagnosis of stroke in computer tomography].

Computertomography permits an early diagnosis of acute intracerebral hemorrhage a few hours after onset of symptoms. Embolic or thrombotic infarcts may be detected only after 2 to 3 days. Late manifestations of ischemic infarcts are unequivocal when confined to the circulation area of a cerebral artery. They must, however, be differentiated from small gliomas with edema, while in cerebral hemorrhage the differential diagnosis must consider bleeding from tumors and vascular malformations.

Brain Neoplasms↗
PubMed1976

[Axial computer tomography of the brain].

Computertized tomography of the brain, developed by Hounsfield - has decisively altered neuroradiologic procedures. Without the need of contrast media, cerebral structures (ventricles cisternes, sulci and physiological calcifications) and pathologic lesions (infarctions, hemorrhage, edema, tumors and malformations) may be visualized. Tumors can be diagnosed in 95 to 99% by this method. Tumors of the midline structures and of the posterior fossa are more easily detected than by conventional methods. In head injuries epidural and subdural hematoma, contusional edema and hemorrhage may be differentiated. Hydrocephalus externus and internus can be shown by computertized tomography. Probably computertized tomography will become the most frequently applied neuroradiological method in the future.

Brain↗