Biomedical subjects
Publications and source records attributed to R Wake.
The structure of the Tus-Ter DNA replication fork arrest complex of Escherichia coli reveals a novel architecture for the bound Tus protein and a new type of DNA-binding motif. The structure of the complex may explain how Tus can block movement of a replication fork approaching from one direction and not the other.
Benign prostatic hyperplasia (BPH) is a nonmalignant, age-related condition that affects most men who enjoy a long life. The diagnosis of BPH is generally straightforward and easily established. At the present time, transurethral resection of the prostate is considered the best mode of therapy for symptomatic BPH requiring active intervention. However, since people are likely to avoid surgery when provided a reasonable alternative, it is likely that pharmacologic treatments will be tried with increasing frequency.
Initial evaluation has begun of a system for displaying left ventricular time-activity curves, relating the intraventricular content of radioactivity with the cardiac cycle as determined by the patient's electrocardiogram. Major problems include proper positioning of the detector, correction for background radioactivity outside the ventricle and calibration of the device to permit conversion of measurement of radioactivity to measurement of ventricular volumes.
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