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Biomedical subjects

R Waldman

Publications and source records attributed to R Waldman.

At least 19 recordsLinked to original sources
PubMed1983

A canonical correlation between adaptive and maladaptive aspects of adaptive behavior.

The relationship between the adaptive and the maladaptive aspects of the construct of adaptive behavior was examined by means of a canonical correlation between Part One and Part Two of the AAMD Adaptive Behavior Scale (ABS). The sample consisted of 439 institutionalized mentally retarded persons. Four significant canonical correlations (.68, .49, .39, .28) were derived, three of which were interpretable. The redundancy index was 30 percent with Part One as the criterion and 14 percent with Part Two as the criterion. A redundancy of about 30 percent was calculated. An analysis of the pattern of canonical components suggested that the three major dimensions responsible for the overlap between ABS Parts One and Two are intellectual ability, sociability, and physical ability. An attempt to cross validate these results was made using another sample of 157 mentally retarded persons. Considerable shrinkage was observed on three of the roots.

Adaptation, Psychological↗
PubMed1982

A clinical evaluation of occlusal composite and amalgam restorations: one- and two-year results.

A two-year study was conducted to compare the qualitative advantages, if any, of a conventional, cold-curing composite resin to amalgam in occlusal Class I cavities in posterior teeth. The composite was placed into modified, conservative cavity preparations using the acid etch technique. Sixty-one pairs of contralateral restorations were evaluated. Forty-six percent of the amalgams and 42.6% of the composites were considered sound. The major deficiency of each material was rough or chipped margins of the amalgams (38%) and worn surfaces of the composites (26%). The use of conservative cavity preparations and the acid-etch technique with bonding agent and final glaze improved the longevity of the composite restorations compared to previous studies. However, the improvement does not suggest that this method will have a long-term effect on clinical success nor does it indicate that composite is superior to amalgam other than in marginal integrity and esthetics.

Acid Etching, Dental↗
PubMed1976

Comparative clinical and laboratory evaluation of the prophylactic capacity of ribavirin, amantadine hydrochloride, and placebo in induced human influenza type A.

The comparative prophylactic effectiveness of oral treatment with ribavirin (1-beta-D-ribofuranosyl-1,2,4,triazole-3-carboxamide; virazole) and amantadine hydrochloride against artificially induced infection with influenza A virus was evaluated in 29 seronegative men who received ribavirin capsules (200 mg) three times daily, placebo capsules three times daily, or amantadine capsules (100 mg) twice daily. Medication was started two days before the inoculation of 2 X 10(4) 50% tissue culture infective doses of A University of Maryland/2/74 (H3N2) influenza virus and was continued for eight days after challege. Nine of the 10 subjects who received ribavirin, eight of the nine subjects who received placebo, and six of the 10 subjects who received amantadine developed influenzal illness. Significantly less virus was isolated from the amantadine-treated group than from the placebo-treated or the ribavirin-treated group. Antibody responses of the ribavirin-treated and placebo-treated groups were quite similar to each other; however, prophylactic treatment with amantadine significantly reduced titers of serum antibody and febrile responses. In a separate clinical trial involving challenge with A/Dunedin/73 (H3N2) influenza virus, ribavirin also failed to show prophylactic effectiveness.

Adult↗
PubMed1975

Immunoglobulin A glomerulonephritis: a clinicopathologic study.

Renal biopsies from 10 patients staining predominantly for immunoglobulin A are reviewed. Historically, nine of 10 patients were less than 32 years of age; they all presented with either microscopic or gross hematuria. The initial creatinine clearances demonstrated good function in all patients; only one patient experienced a progressive decline in the creatinine clearance. Similarly, proteinuria was mild. The light and electron microscopic findings presented a variable pattern, including a group with changes confined to the mesangium, another group also having glomerular basement membrane changes, and one patient with severe, progressive glomerular sclerosis. Immunogluorescence demonstrated large amounts of IgA predominantly within the mesangium but occasionally involving the peripheral capillary loops. Serum IgA levels were elevated in six of eight patients tested, and two of five patients had elevated nasal IgA concentrations. These data suggest that there is an immunologic entity, IgA glomerulonephritis, characterized by the above clincial findings in association with elevated serum and occasionally nasal IgA levels, but that the pathologic findings are highly variable. Neither the mechanism nor the particular pathogenetic significance of the raised IgA levels is presently known. The similarities of this entity to the reported findings in anaphylactoid purpura are mentioned.

Administration, Intranasal↗