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Biomedical subjects

R Waltman

Publications and source records attributed to R Waltman.

At least 19 recordsLinked to original sources

Prolongation of rat gestation time by unsaturated fatty acids.

Arachidonic, linoleic, linolenic, and oleic acids, administered to Sprague-Dawley rats on Days 20 and 21 of gestation prolonged the gestation time; neither the duration parturition, parturitional bleeding, nor the perinatal mortality rate was affected. Since arachidonic acid is the obligatory precursor of prostaglandins E2 and F2 alpha, currently believed to be associated with the initiation of labor, and polyunsaturated fatty acids inhibit the cell-mediated immune response in vivo, the precise role of prostaglandins and their precursors in the initiation of parturition must be critically examined.

Animals↗

Effect of aspirin on bleeding time during elective abortion.

The template bleeding time, indicative of a predictable measure of potential blood loss due to altered platelet function, is unaffected by pregnancy or by the first stage of labor. Two tablets of aspirin (650 mg), but not sodium salicylate or acetaminophen, significantly prolongs the template bleeding time for at least 26 hours after consumption in patients undergoing first or second trimester induced abortion. Patients anticipating induced pregnancy interruption should refrain from any aspirin consumption for at least 26 hours prior to abortion.

Abortion, Induced↗