PubMed Health⌕ Search

Biomedical subjects

R Wegmann

Publications and source records attributed to R Wegmann.

At least 37 records · Page 2Linked to original sources
PubMed1981

Activation of melanogenesis in the beagle by a vasodilator, mecinarone.

Mecinarone (18.25 mg/kg twice a day orally for 6 months) induces an increase in melanin content of pigmented skin and mucosae in the Beagle dog. This effect is reversible. This effect is not due to a central or an endocrine mechanism because plasma levels of M.S.H., A.C.T.H. and cortisol remain normal. High levels of Mecinarone are found in melanized areas (skin, hair and non tapetal area of the eye). This effect is reversible. In contrast wih the Beagle, studies in pigmented guinea-pig and rabbit have been negative.

Adrenocorticotropic Hormone↗
PubMed1980

[Histoenzymatic study of the effects of aluminium phosphate on the gastric mucosa (author's transl)].

Gastric biopsies were performed before and after a 1-month aluminium phosphate gel treatment on 12 patients with gastritis or peptic ulcer requiring endoscopy. The sections were stained with various dyes used in histoenzymatic techniques, and colour intensity was evaluated double-blind by means of 0 to 5 scores. Compared with pretreatment levels, there was a statistically significant rise in PAS-toluidine blue activity, which measures mucus secretion (p less than 0.001) and in succinic dehydrogenase activity, an enzyme associated with cell respiration (p less than 0.05). The meaning of these changes is discussed. The mode of action of aluminum phosphate gels on the gastric mucosa remains hypothetical, but a direct contact induction mechanism seems more acceptable than an indirect mechanism involving non-specific reduction in intragastric acidity. Provided the results are statistically evaluated on a sufficient number of samples, PAS-toluidine blue and succinic dehydrogenase stains appear to constitute an easily measurable potential index of intracellular metabolic activity within the gastric mucosa. They could be used as markers to study the efficacy and biochemical mode of action of old and new drugs for gastro-duodenal disorders.

Adult↗
PubMed1980

[The value of laboratory tests (author's transl)].

The diagnostic significance of various laboratory tests was studied at a Medical University Clinic and a regional hospital. Requests for such tests were graded on admission according to the criteria: (a) necessary for differential diagnostic decision; (b) part of routine admission programme. Results were assessed according to the criteria: (a) clinical "proof"; (b) of value in differential diagnosis; (c) pointing to another diagnosis; (d) unhelpful. Analysis of the results provided an interesting agreement: all doctors graded seven to ten tests as necessary. Those with the highest information content were the classical tests--erythrocyte sedimentation rate, serum-electrophoresis and blood sugar levels. 45.6% of those graded as necessary proved informative; 7.2% of routinely ordered tests provided pointers to another diagnosis. This percentage is the contribution of laboratory tests beyond what doctors consider as necessary for diagnosis. This additional value of laboratory tests is relatively high so that a reasonably extensive programme of laboratory tests on admission appears justified, especially if one adds the time factor to cost-effectiveness.

Blood Glucose↗
PubMed1979

[Experiences with Pirenzepin in the therapy of peptic ulcers (author's transl)].

21 patients with peptic ulcers were treated with 2X25 mg Pirenzepin daily. A decrease in basal and Pentagastrin-stimulated HCl-secretion was found. Patients with duodenal ulcers (n = 12) or gastric ulcers (n = 9) became painless within 6 to 11 days. 18 ulcers healed under treatment with Pirenzepin. Patients with duodenal ulcer showed recovery sooner than patients with gastric ulcer. One year later recurrent ulcers were observed in 4 cases. Side-effects of Pirenzepin did not occur.

Adult↗