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Biomedical subjects

R Wenk

Publications and source records attributed to R Wenk.

26 records · Page 2Linked to original sources
PubMed1986

31P and 23Na NMR studies of the structure and lability of the sodium shift reagent, bis(tripolyphosphate)dysprosium(III) ([Dy(P3O10)]7-) ion, and its decomposition in the presence of rat muscle.

The 31P NMR of aqueous [Dy(P3O10)2]7- demonstrates that it is in slow exchange with P3O5-10 on the NMR time scale. In the presence of tissue, [Dy(P3O10)2]7- decomposes to PO4 with an accompanying slow change of the tissue 23Na NMR of extracellular Na+ ion in several NMR distinguishable extracellular sites.

Animals↗
PubMed1981

Serum hormones and lipoproteins in benign breast disease.

Seventeen young women with clinically confirmed mammary dysplasia and six age-matched controls were treated with alpha-tocopherol. Serum samples collected during the luteal phase of each woman at monthly intervals for the 4-month duration of the study were analyzed for serum luteinizing hormone, follicle-stimulating hormone, and prolactin concentrations by radioimmunoassay and for lipoprotein levels by a combination of precipitation, ultracentrifugation, and enzymatic techniques. Fifteen patients showed objective and subjective remission from disease. While prolactin levels did not change significantly, elevated levels of luteinizing and follicle-stimulating hormones were decreased to normal levels. Ratios of serum cholesterol to high-density lipoprotein cholesterol decreased; high-density lipoprotein and free cholesterol associated with low-density lipoproteins increased as a result of therapy. The results suggest that alpha-tocopherol may serve as an effective agent not only to treat patients with benign breast disease but also to normalize abnormal hormone and lipid levels in subjects at high risk for breast cancer.

Breast Diseases↗
PubMed1967

Prevention of induced atherosclerosis by peroxidase.

Hepatocatalase peroxidase, an active peroxidase-oxidase subunit isolated from beef-liver catalase, prevents cholesterol deposition and aortic atherosclerosis in cholesterol-fed rabbits and has no apparent toxicity or undesirable de effects. No allergic or immunological reactions have been observed. The participation of this enzymatic subunit in homeostatic control mechanisms and its potential pharmacological value in the control of human atherosclerosis are suggested.

Alkaline Phosphatase↗
PubMedDate not supplied

Paternity probabilities of biologic fathers and unexcluded, falsely accused men using blood group markers.

A frequent legal argument raised in defense of men accused of paternity, but not excluded by genetic tests, is that the probabilities of paternity of falsely accused men are similar to those of biologic fathers. This assertion was tested in a computer simulation experiment that used a database of 15,000 actual paternity cases to provide red cell and HLA phenotypes of mothers, children, and putative fathers. Tests had a combined probability of exclusion of 97.3 percent. Equal numbers of true and false fathers were generated from the data by computer to achieve a prior probability of paternity of 0.5. True fathers' phenotypes were those of unexcluded men from actual cases (Group A) or of mothers from actual cases (Group B) in which paternity was not excluded. The false father group was created by assigning the phenotypes of racially identical men who were selected at random from among cases other than their own. Probabilities of paternity were calculated for the men in each group and were classified into descriptive intervals. The frequency of men in each group was compared in each interval. The frequency distributions of probabilities of paternity for true fathers and unexcluded, falsely accused men (false fathers) were markedly dissimilar.

Computer Simulation↗