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Biomedical subjects

R Wepler

Publications and source records attributed to R Wepler.

11 recordsLinked to original sources
PubMed1992

[Significance of drug determination in pilocarpine sweat for detection of past drug abuse].

The presence of cocaine, morphine and methadone in sweat samples obtained after stimulation of the eccrine sweat glands, from drugs users after six drugs-free days, was investigated. The stimulation of the sweat elimination was proved using pilocarpine-iontophoresis every hour for 7 hours. The drugs concentrations were determined by radioimmunoassay. Consequently, the values measured represent the sum of the drug and its metabolites. Measurable levels of cocaine, morphine and methadone were obtained after the third stimulation of the glands.

Adult↗
PubMed1978

[Diagnostic value of the lipoprotein-X determination (author's transl)].

LP-X was investigated in the serum of 221 patients with and without cholestasis. The diagnostic sensitivity and the diagnostic specificity of the test were 0.9 and 0.88, respectively. When this test is used on a non-selected collective, however, the predictive value of the positive test is very low, whereas negative results have a high diagnostic value. Thus, in practice, LP-X is more suitable for the exclusion, rather than the detection of cholestasis.

Cholestasis↗
PubMed1977

The influence of fluocortolone treatment on the collagen content in guinea pig skin.

Specific pathogen free guinea pigs were treated with varying dosis of fluocortolone for 15 days. The treated animals showed the same per cent weight gain as the controls. The total hydroxyproline content of the skin and the hydroxyproline content in different collagen fractions was the same in treated and untreated animals. Thus fluocortolone seems to have no specific effect on the synthesis or the breakdown of collagen in the guinea pig skin. Also the physical development of the animals, kept under defined conditions, failed to show a catabolic effect of of fluorcortolone.

Animals↗
PubMed1977

[Polyuria].

Explore the source record for details and available documents.

Humans↗
PubMed1977

[Clinical chemistry and preventive medicine (author's transl)].

In a workshop conference of the German Society for Clinical Chemistry, clinical chemical parameters, which are important in preventive medicine, were discussed for three common diseases, diabetes mellitus, gout and chronic liver diseases. In addition the analytical and diagnostic reliability was evaluated for each of these parameters.

Chemistry, Clinical↗
PubMed1976

[Oral glucose tolerance test with a mixture of oligosaccharides after partial gastrectomy (author's transl)].

Fourteen non-diabetic male patients undergoing partial gastrectomy for ulcer disease were investigated with oral glucose tolerance test using a 100 g mixture of oligosaccharides. Partial gastrectomy had been performed between 1 and 3 years ago. Compared to seven healthy male control subjects, patients had significant higher blood glucose levels at 30 and 60 min and a more rapid descent, so that at 120 and 180 min no differences were found between patients and control subjects. With the usual criteria (blood glucose levels at 120 and 180 min) the non-diabetic patients with partial gastrectomy showed normal test results.

Adult↗