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Biomedical subjects

R Westphal

Publications and source records attributed to R Westphal.

At least 19 recordsLinked to original sources

Sensors, medical image and signal processing. Findings from the Section on Sensor, Signal and Imaging Informatics.

OBJECTIVES: To summarize current excellent research in the field of sensor, signal and imaging informatics. METHODS: Synopsis of the articles selected for the IMIA Yearbook of Medical Informatics 2006. RESULTS: The selection process for this yearbook's section 'Sensor, signal and imaging informatics' results in six excellent articles, representing research in five different nations. We selected a cross section of the wide range of application, ranging from model based image segmentation, image retrieval and data mining, image based diagnosis assistance, bio-impedance based skin cancer screening, brain computer interfaces to MRI based computational models for fluid-structure-interactions. CONCLUSIONS: The selected articles indicate a small but meaningful extract from the research field of sensors, signal and image processing, which has a wide range of applications in medical informatics. The articles present excellent research with a possibility of having high relevance for the future in patient care.

Awards and Prizes↗

Robot-assisted fracture reduction: a preliminary study in the femur shaft.

Reduction in femoral shaft fractures can be difficult to achieve with minimally invasive techniques. Malalignment and high intra-operative radiation exposure can result. The hypothesis was that robot-assisted fracture reduction could improve the quality of reduction while reducing the amount of radiation exposure. A robot system was developed that allows fracture manipulation with a joystick as input device. The system provides the surgeon with haptic and metric feedback. Fifteen synthetic femurs were broken and reduced by simulated open (group A) and closed techniques (group B). These techniques were compared with the robot-assisted reduction with (group C) and without (group D) haptic and metric information. An image intensifier was simulated with two orthogonal cameras. All reduction techniques showed minor malalignment. In group C, the alignment was: procurvatum/recurvatum 0.6 degrees (0-2.0 degrees); varus/valgus 0.8 degrees (0-3.0 degrees); and axial rotation 0.8 degrees (0-3.1 degrees). A significant difference was seen between the groups (two-way ANOVA, p < 0.001). Axial rotation was significantly lower in group C than in group B (1.9 degrees; p < 0.001). The residual varus and valgus deviation was higher in group C compared with group A (0.4 degrees, p = 0.03). The median number of simulated radiographs was significantly less in group C (35) compared with group D (72; p < 0.001) and group B (49; p = 0.01). Robot-assisted fracture reduction of the femur provides high precision in alignment while reducing the amount of intraoperative imaging. Further research in this field is worthwhile.

Femoral Fractures↗

A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes.

The specificity of intracellular signaling events is controlled, in part, by compartmentalization of protein kinases and phosphatases. The subcellular localization of these enzymes is often maintained by protein- protein interactions. A prototypic example is the compartmentalization of the cAMP-dependent protein kinase (PKA) through its association with A-kinase anchoring proteins (AKAPs). A docking and dimerization domain (D/D) located within the first 45 residues of each regulatory (R) subunit protomer forms a high affinity binding site for its anchoring partner. We now report the structures of two D/D-AKAP peptide complexes obtained by solution NMR methods, one with Ht31(493-515) and the other with AKAP79(392-413). We present the first direct structural data demonstrating the helical nature of the peptides. The structures reveal conserved hydrophobic interaction surfaces on the helical AKAP peptides and the PKA R subunit, which are responsible for mediating the high affinity association in the complexes. In a departure from the dimer-dimer interactions seen in other X-type four-helix bundle dimeric proteins, our structures reveal a novel hydrophobic groove that accommodates one AKAP per RIIalpha D/D.

Amino Acid Sequence↗

[Significance of selected preventive, therapeutic and rehabilitation services reflected in a population survey].

BACKGROUND: Statutory health insurance bodies in Germany are experiencing increasing deficits, which raises the demand for rationalising health benefits. This, however, requires the establishment of priorities unless absolutely necessary benefits have to be cut. In other words, we must examine the preferences, expectations and experiences of the insured population. Within the framework of this study, we tried to find out the preferences and assessment of health services by the German population in the Lübeck region. DESIGN: Mail survey (questionnaire and two reminders) to register the preferences and attitudes to guaranteed medical services in the light of threatening deficits. The random sample was drawn by the residents' registration office in Lübeck, the criteria being an age of between 25 and 64 years, German nationality and principle domicile in Lübeck. INSTRUMENT: Postal questionnaire with 7 pages including 9 question complexes on the importance of preventive, curative and rehabilitative health services with 88 items and personal data. RESULTS: We succeeded in contacting 992 persons and achieved a response rate of 64.1%. 67% of the participants (n = 634) conveyed about their opinion on economic decisions in health care. 12% refused any involvement. In respect of importance and the cost of medical interventions, preventive, curative and rehabilitative interventions for children have highest priority. In the curative and rehabilitative sphere the emphasis lies on the severity of the illness. Interventions with controversial effectiveness were rated less important by the respondents and hence these should not be financed by the health insurance companies in every case, in the opinion of the persons who had been questioned. CONCLUSIONS: The evaluation shows that most participants could cope quite well with this questionnaire and were ready to be involved in decisions concerning health care. Like the participants of Ann Bowling's survey about the investigation of preferences in the UK, our respondents give medical interventions for children (independent from the medical sector) a higher priority. Mit vorang. Satz weicht die engl. Zusammenfassung von der dt. Zusammenfassung ab Apart from this it is obvious that interventions with controversial effectivity should not be covered by the health insurance companies to the same extent as those with established effectivity, which is, in a way, in contrast to valid German legal regulations.

Adolescent↗

[Relevance and financing of health services: a survey of physicians, students, patients, nursing personnel and seniors].

BACKGROUND: In Germany public opinion is increasingly in favour of being included in decisions on priority and rationalisation of health care, as practiced in other countries for years. One question is, which influence medical know-how and patients' experience have on the assessment of health services (importance or reimbursement of expenses). In addition to a representative survey it would be appropriate to include certain groups like physicians, medical students, nursing staff, patients and inhabitants of old people's homes in a relevant survey. DESIGN: We conducted a survey of six groups, differing in medical know-how, personal affliction and age, by a highly standardized questionnaire. The group of physicians received the questionnaire by mail with one reminder. The questionnaire was handed out to the other groups (directly). SETTING: 150 practices of internal specialists and general practitioners in and around Lübeck, a preclinical and a clinical semester of the Medical University of Lübeck, an old people's home in Lübeck-Travemünde and a cardiological clinic for rehabilitation in Bad Segeberg. SUBJECTS: 150 practising physicians (internal specialists, general practitioners), 100 medical students of a preclinical semester and another 100 of the fifth clinical semester, 100 patients in cardiological consulting hours in a cardiological clinic, 100 members of the nursing staff of the same clinic and 110 residents in an old people's home. The survey period was between December 1997 and February 1998. INSTRUMENT: The questionnaire was identical to a parallel public survey. On the one hand defined health services were assessed in respect of importance and reimbursement of expenses. On the other hand, more general questions were asked regarding possible ways of financing or economization in public health. RESULTS: A response rate of 82% was achieved in the group of inhabitants of the old people's home. Doctors and students showed a response rate between 60% and 70%, while the response rate of patients and nursing staff was about 50%. A clear agreement between groups could be found in the evaluation of health services in the case of severe illnesses of children, which achieved the highest rating. The evaluation of health services of controversial effectivity like homoeopathic drugs or acupuncture varied most. There was a tendency in the patients' group to rate the importance of the listed health services higher than in the other groups, especially doctors and clinical students. All groups showed readiness to assign more financial consequences to patients with illnesses caused by the patient's behaviour, e.g. dangerous forms of sports or smoking. CONCLUSION: Laity as well as experts showed a distinct interest in the complex subject. Medical know-how goes along with a more critical evaluation of the importance of numerous indications. Patients distinguished less between different health services. The questionnaire showed that those directly concerned wish to be included in the discussion and feel that decisions concerning priority-setting in public health should not be left to politicians and health insurance companies alone.

Adolescent↗

Clinical experience with stentless pericardial aortic monopatch for aortic valve replacement.

A stentless pericardial aortic monopatch was used in 60 consecutive patients undergoing aortic valve replacement. The monopatch is constructed of a sheet of glutaraldehyde-treated bovine pericardium, tailored and shaped to fit the aortic anulus, and is sutured in place without a stent or sewing ring. The valve area is effectively preserved by this method. Results indicate that this technique is simple, inexpensive, and applicable to all cases of aortic valve disease. It does not require anticoagulation and may allow for annular growth when used in children. This technique is particularly suitable for patients with infective endocarditis because the amount of foreign material is minimized.

Adolescent↗

Infant care and feeding in an urban black population.

Health education programmes aimed at improving infant feeding must be developed from data on current practices and growth. Infants born in Pimville, Soweto, were traced when they were 6 weeks old and again at 6 months and their mothers and child-minders were interviewed. Length of tay in the area, breastfeeding and weaning intention and practice, age standard of education, understanding of Boston growth charts, and infant growth data were investigated. It is suggested that more specific health education programmes need to be developed and that community-based health workers need to be selected and trained to assist and support mothers in learning better feeding practices.

Adolescent↗

Health education--quo vadis?

Various implications for health education in relation to current approaches to community medicine are reviewed. Health education activities and needs in the Republic of South Africa are surveyed. Suggested solutions to existing problems include the development of more co-ordinated planning and implementation and evaluation of health education programmes. The urgent need for both undergraduate and postgraduate teaching facilities is stressed. It is suggested that the role and services of the South African National Council for Health Education should be reviewed, so that the Council's resources can in future be better utilized.

Health Education↗

[Health Year].

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Community Participation↗