Biomedical subjects
Publications and source records attributed to R Wipf.
Occupational diseases are defined in the light of present and forthcoming legislation. Administrative processing and the conditions for indemnity are described. The problems surrounding the level of disability pensions for silicotics and the determination of annual income are central to the discussion. International conventions and judicial procedures are briefly reviewed.
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The authors studied the immunitary responses to Levamisole in a group of patients recently operated for bronchogenic carcinoma. The results were compared with those obtained from two other groups, i.e. one of patients recently operated of bronchogenic carcinoma but not treated with Levamisole and another one of patients recently operated for a non-neoplastic disease and also not treated with Levamisole. All subjects underwent a similar investigation of the cell-mediated and the humoral immunity parameters at the beginning of the study and after 30 days. The comparison of the results showed a depression of the cell-mediated immunity in the patients operated for bronchogenic carcinoma. This depression subsided more promptly in patients submitted to Levamisole therapy. This effect was achieved particularly through a better blastogenic responsiveness to the PHA and an enhanced Rosettes E forming. The use of Levamisole in the pre- and post-operative period is thought to be beneficial in order to avoid distant recurrences. This effect is obtained by a stimulation of host defense mechanisms.
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A study of blood gasometry at rest and after exercise was carried out on 98 subjects: 49 healthy, 31 cases with "small airway disease" and 18 cases of clinically nondecompensated obstructive lung disease. The most interesting results arose from the study of PaO2. Its mean value increased after exercise in all groups, but in a manner less obvious as the bronchial obstruction appeared and increased. This increase was almost imperceptible in obstructive patients. The whole of gasometric behaviour ranged the subjects with "small airway disease" in an intermediate position between the normal controls and the obstructive patients. This finding leads the authors to suppose that the "small airway disease" implies the existence of disorders of intrapulmonary gas exchanges which foreshadow the obstructive disease.
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The authors report an unusual case of diffuse bronchial calcinosis of established histology, found during a routine bronchoscopy in a pulmonary tuberculous patient aged 46. The lesions consisted in several small pale bulgings on the wall of the main bronchi on both sides. This finding led to the diagnosis of rough primary hyperparathyroidism.
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The author has investigated the feasibility of DME 25--75/C.V. as a test for the detection of ventilatory disturbances of the small aerial pathways, by comparing the results with those of other tests considered to be very sensitive, such as Vmax 50% and 25% of C.V., Vmax 50% and 25% of C.V. of an air curve and that of a He-O2 mixture (80%--20%), and the isoflow volume. The study was carried out in 90 subjects, divided in two groups in relation to the values obtained by the DME 25--75/C.V., as follows : 44 subjects with bronchial obstruction and 46 subjects showing functional signs of obstruction of the small aerial pathways. The results have indicated that the two populations classified according to this criterium are statistically different also with regard to other tests applied, indicating the feasibility of the test under study, which, compared to other tests, has the advantage of higher sensitivity in relation to the simplicity of the device.