Biomedical subjects

R Y Du

Publications and source records attributed to R Y Du.

14 recordsLinked to original sources

PubMed1991

Effect of cimetidine on wedged hepatic venous pressure in cirrhotic patients.

According to our supposition that "humoral mechanism" plays an important role in the pathogenesis of portal hypertension due to cirrhosis, antagonists to some of humoral substances would lower the portal pressure in cirrhotic patients. Wedged hepatic venous pressure (WHVP) was used as an indicator for changes of portal pressure. Cimetidine was given intravenously to 8 cirrhotic patients, in whom an average lowering of 0.72 kPa (7.3 cm H2O) of WHVP was observed subsequently. This change was of clinical significance as compared with the previous results of splenorenal shunting operations.

Adolescent↗

PubMed1990

Changes of blood humoral substances in experimental cirrhosis and their effects on portal hemodynamics.

The changes of humoral substances in the blood of cirrhotic rats were studied together with their effects on portal hemodynamics at different stages during the development of cirrhosis. The profiles of humoral substances and hemodynamics in two different cirrhotic rat models were also investigated. During the development of cirrhosis, glucagon increased markedly in all stages, histamine and vasoactive intestinal polypeptide (VIP) increased in the early stage, serotonin (5-HT) and somatostatin (SS) increased in the middle and late stages. There were different patterns of humoral substances in different cirrhotic models. Glucagon was the main humoral substance elevated in CCL4 induced cirrhosis, but histamine and 5-HT were mainly elevated in the blood in thioacetamide (TAA) induced cirrhosis. The hemodynamics altered differently in different stages during the development of cirrhosis and differently in the two cirrhotic rat models. Exchange transfusions between normal and cirrhotic rats resulted in an elevation of portal flow in normal rats, but no such changes were found after exchange pressure and an increase of portal blood transfusions between normal rats. The relationship between the humoral substances and portal hemodynamics is discussed. The results of this study strongly support the hypothesis of "humoral mechanism" in the pathogenesis of portal hypertension due to cirrhosis.

Animals↗

PubMed1989

[The accuracy of locating the accessory pathway before and during surgery in patients with Wolff-Parkinson-White syndrome].

The accuracy of locating the accessory pathways (APs) before and during operation in the operated 32 patients with the Wolff-Parkinson-White syndrome (WPW) was reported. There were 27 cases with the single AP, in which 17 had left-lateral free-wall pathways, 6 had left-posterior free-wall pathways, 2 had posterior septal pathways, 1 had right free-wall pathway and 1 had anterior septal pathway, and 5 cases with double APs. Taking the double APs as a single apparent AP, the accuracy was 87% (20/23) by electrocardiograms (exclusive of 9 concealed WPW), 94% (30/32) by electrophysiologic studies (EPS) and 97% (31/32) by epicardial mappings (ECM). It was difficult to discover and locate the double APs. For the 10 APs of 5 cases with double APs, the accuracy was 60% (6/10) by EPS and 70% (7/10) by ECM.

Adolescent↗

PubMed1988