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R Yeo

Publications and source records attributed to R Yeo.

13 recordsLinked to original sources
PubMed2003

FIGO stage 1B2 cervical carcinoma--the KK Women's and Children's Hospital experience.

INTRODUCTION: The objectives of this review were to document the surgico-pathological characteristics of surgically resected FIGO stage 1B2 cervical carcinoma and to review our overall experience with this disease. MATERIALS AND METHODS: This is a retrospective review of 35 patients diagnosed and treated from September 1990 to November 2001. RESULTS: The median age was 42 years and the mean tumour diameter was 5.1 cm. Majority were squamous cell carcinomas (65.7%), 28.6% were adenocarcinomas and 5.7% were adeno-squamous carcinomas. The primary treatment comprised radical surgery in 77.1%, radiotherapy in 20% and neoadjuvant chemotherapy followed by radical surgery and adjuvant radiotherapy in 2.9%. Significant surgico-pathological features noted were deep stromal invasion (66.7%), lympho-vascular space invasion (55.6%), parametrial involvement (22.2%), positive margins (3.7%) and pelvic node metastases (33.3%). Postoperative radiation was given to 92.6% of the patients who underwent primary surgery, of whom 29% received concurrent chemotherapy. Radiation toxicity was mild with no grade 3 or 4 toxicity documented. For the patients who had surgery, the recurRence rate was 14.8% (11.1% pelvic and 3.7% distant) and the survival rate was 88.9%. For those who had primary radiation, the rate of persistent disease was 28.6%, the distant recurrence rate was 28.6% and the survival rate was 57.1%. CONCLUSION: FIGO stage 1B2 cervical carcinomas are associated with significant rates of adverse surgico-pathological features. The ideal primary treatment is yet to be established and should be determined by prospective randomised trials.

Adult↗
PubMed1997

Topical and subconjunctival anesthesia for phacoemulsification: prospective study.

PURPOSE: To evaluate the efficacy and safety of topical and subconjunctival anesthesia for phacoemulsification and to compare the results with those of retrobulbar-peribulbar anesthesia. METHODS: This prospective study evaluated 402 patients having phacoemulsification during 60 surgical sessions. Patients were randomly assigned to receive a topical and subconjunctival injection of lidocaine 4% or a retrobulbar injection of the same anesthetic. RESULTS: Patients who received topical and subconjunctival anesthesia received less anesthetic (0.25 versus 3.25 mL) and had fewer side effects from the intravenous sedation and a lower incidence of capsular rupture associated with positive vitreous pressure during surgery (0 versus 2.9%). The difference in postoperative discomfort was not statistically significant, and there were no complications resulting from needle insertion. CONCLUSION: Topical and subconjunctival anesthesia using lidocaine 4% was as effective as retrobulbar and peribulbar anesthesia for routine phacoemulsification. In addition, fewer anesthetic drugs and less patient sedation were required, and there were fewer intraoperative and postoperative complications.

Administration, Topical↗
PubMed1994

The relative prognostic significance of total cathepsin D and HER-2/neu oncogene amplification in breast cancer. The South Australian Breast Cancer Study Group.

Total tumor cathepsin D (TCD) levels were determined prospectively by a radioimmunometric assay in tumor cytosol of 858 primary breast cancer patients diagnosed between 1989-1991. In 581 of these patients, tumor HER-2/neu oncogene amplification was simultaneously determined. In a "training-set" of 313 patients, "high" TCD was associated with significantly shorter disease-free survival (DFS). For the whole group, there was no correlation between TCD and pathologic stage, number of axillary nodes with tumor deposits, tumor size, histologic type and grade, or hormone receptor levels. In the node-positive group, high TCD level was associated with HER-2/neu amplification. After a median follow-up duration of 31 months, univariate analysis indicated that high TCD level was significantly associated with shorter DFS only in node-positive patients. The shorter DFS in association with high TCD levels was observed in both estrogen-receptor-positive and -negative patients. Cox multivariate analysis of DFS confirmed that high TCD level was predictive of shorter DFS in node-positive patients only. Because of the short duration of follow-up, the significance of TCD in overall survival was not determined. We conclude that high tumor TCD in node-positive patients is predictive of shorter DFS, and is often associated with HER-2/neu amplification. The possibility exists that high tumor TCD may act in combination with HER-2/neu amplification to promote dissemination of metastases.

Adult↗
PubMed1987

The effects of task complexity on motor performance in left and right CVA patients.

The effects of task complexity on movement ipsilateral to lesion were examined using the Fitts tapping task [Fitts, P.M., J. exp. Psychol. 47, 381-391, 1954]. Subjects were required to rapidly tap two targets, which were 1 or 4 cm wide. Twenty controls and ten left hemisphere and nine right hemisphere stroke patients were studied. Only the left hemisphere group showed significant deficits with greater impairment found in the wide target condition. Quantified CT scan analyses indicated lesion volume was similar between CVA groups, but the left hemisphere group's lesions were more anterior. The results are discussed in terms of inter- and intrahemispheric roles in open and closed loop movements.

Apraxias↗
PubMed1987

Respiratory tract infections due to Branhamella catarrhalis: epidemiological data from Western Australia.

During a 3-year period Branhamella catarrhalis was isolated in significant numbers from 239 (1.3%) of 19,488 specimens of sputum sent for routine microbiological examination at a 700-bed general hospital. The majority of patients (83%) were over 60 years of age and 65% were male. There was a distinct seasonal variation in isolations with a peak incidence during the winter and early spring, a pattern not found with other pathogens. Susceptibility to amoxycillin decreased by approximately 50% over the 3 years, corresponding to an increased incidence of beta-lactamase-producing strains. There were minimal changes in susceptibility to other antimicrobial agents. Underlying pulmonary disease was the major factor predisposing to B. catarrhalis infection, and 71% of patients were smokers or ex-smokers.

Adult↗
PubMed1986

Stuttering: disappearance and reappearance with acquired brain lesions.

Despite 60 years of study, the brain mechanisms for stuttering are unknown. In an effort to shed light on these mechanisms, we studied two cases in which the fluency of speech changed after brain damage in adulthood. The first, an ambidextrous man, ceased to stutter after a head injury. The second, a converted left-handed man, experienced recurrence of childhood stuttering after a stroke.

Adolescent↗
PubMed1968

Emergency resection in treatment of diverticular disease of colon complicated by peritonitis.

Of a consecutive series of 25 patients with peritonitis secondary to colonic diverticular disease all, except one with faecal peritonitis, underwent some form of emergency resection.All the three patients with faecal peritonitis died, but the 22 with purulent peritonitis survived. The average duration of the emergency admission of the 22 survivors was 25.4 days, and in nine (41%) of them intestinal continuity had been restored by the end of that admission.Thus some form of emergency resection is the operation of choice in patients with spreading peritonitis due to diverticular disease of the sigmoid colon.

Adult↗