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R Ying

Publications and source records attributed to R Ying.

6 recordsLinked to original sources
PubMed2006

Ulinastatin attenuates lung ischemia-reperfusion injury in rats by inhibiting tumor necrosis factor alpha.

UNLABELLED: Ischemia-reperfusion (I/R) injury may influence graft function following transplantation. Ulinastatin, a urinary trypsin inhibitor has been shown to attenuate I/R injury in various organs such as intestine, heart, and kidney in animals. The present experiment was designed to evaluate the effect of pretreatment with ulinastatin on I/R-induced lung injury. METHODS: After establishing a constant left lung warm ischemia-reperfusion model in rats, 45 animals were randomly divided into three experimental groups: sham group (n = 15), IR group (n = 15), and ulinastatin (5000 U/kg pre-ischemia) + IR group (n = 15). The lung injury was evaluated by tissue myeloperoxidase activity, with simultaneous estimation of the serum concentration of TNFalpha. RESULTS: The ulinastatin-pretreated animals exhibited markedly decreased lung tissue myeloperoxidase activity (P < .05). Blood gas analysis demonstrated, that the treated animals had significantly ameliorated pulmonary oxygenation (P < .05). The serum concentration of TNF-alpha in the ulinastatin-pretreated group was markedly decreased compared with that of the I/R group (P < .05). CONCLUSIONS: Ulinastatin attenuated I/R-induced lung injury. This function is partly related to the capacity of the agent to inhibit myeloperoxidase activity in lung tissue and decrease systemic expression to TNF-alpha.

Animals↗
PubMed1995

[Surgical management of severe hemorrhage and retroperitoneal perforation after endoscopic sphincterotomy].

From 1990 to 1993, 5 patients with severe hemorrhage and retroperitoneal perforation following endoscopic sphincterotomy (EST) were surgically treated. Two patients with hemorrhage and one with perforation survived. The remaining two died of hemorrhage plus perforation. Early diagnosis and surgical intervention was very important to lower the mortality, especially in those with common bile duct stones retention, acute pancreatitis, or cholangitis. For patients with late stage perforation or recurrent hemorrhage, palliative procedure aimed at isolating the EST incision from the digestion of bile and pancreatic juice should be performed.

Duodenal Diseases↗
PubMed1995

Hemagglutinins in fungus extracts and their blood group specificity.

A total of 833 fungi harvested from 1977 to 1994 were tested and 422 extracts (47.8%) produced hemagglutination of human red cells. The lectins in fungus extracts which showed blood-group-specific or related reactions were partially purified by ammonium sulfate precipitation and gel filtration on a Sephadex G-100 column. Anti-H-like agglutinins were found in extracts of Pleurocybella porrigens, Naematoloma sublateritium and Pholiota squarrosa. These extracts agglutinated strongly with human group O red cells and rather weakly with A and B cells. Anti-A agglutinins were found in extracts of Hohenbuehelia serotina, Paxillus panuoides, Melanoleuca melaleuca and Hygrophorus capreolarius. The extract of Clavulinopsis fusiformis contained anti-B agglutinin. The ABH reactivities of the extracts were cofirmed by an agglutination inhibition test with ABH secretor saliva and blood group substances from human gastric linings and by the destruction of inhibiting activity using blood-group-specific decomposing enzymes. L-Fucose was the most active inhibiting monosacharide of anti-H-like agglutinins. The reaction of anti-A agglutinins was strongly inhibited by N-acetyl-D-galactosamine. D-Galactose and raffinose and melibiose which contain alpha-galactosyl residues were potent inhibitors of C. fusiformis agglutinin.

ABO Blood-Group System↗
PubMed1995

Fungal anti-A agglutinins with different affinities for subgroups A1 and A2 red cells.

We found two anti-A hemagglutinating lectins in the extracts of the fruiting bodies of two fungi (93-34, 93-138) belonging to the Tricholomataceae family. The extracts reacted with papain-treated human group A red cells but not with O or B cells. Both fungus lectins gave negative results with saline suspensions of human and animal red cells. In agglutination tests against red cells of A subgroups, 93-34 gave similar results to Dolichos biflorus, such as a stronger reaction with A1 than with A2 cells, while 93-138 showed stronger agglutination of A2 than of A1 cells. Using both fungus hemagglutinating lectins with human standard anti-A serum it was possible to distinguish subgroups of A1 and A2. The activity of both lectins was inhibited by A secretor saliva and A substance from human stomach linings. A-decomposing enzyme from Clostridium tertium A destroyed this inhibiting activity of the reaction of lectins with A cells. N-Acetyl-D-galactosamine was the only potent inhibitor of the hemagglutination reaction among the monosaccharides tested. No agglutination was observed with Cad(+) red cells. The results suggested that two lectins have affinity with terminal alpha-linked N-acetylgalactosaminyl residues of polysaccharide side chains.

ABO Blood-Group System↗