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Biomedical subjects

R Zamir

Publications and source records attributed to R Zamir.

At least 55 records · Page 3Linked to original sources
PubMed1980

HLA antigens in ulcerative colitis and Crohn's disease in Israel.

The frequency of HLA antigens was studied in 60 Israeli Jewish patients with ulcerative colitis (UC) and in 18 with Crohn's disease (CD), and it was compared to that in healthy, ethnically-matched controls. From this study it would appear that HLA-BW 35 is highly associated with UC in Israeli Jewish patients and that HLA-AW 24 is present at a high frequency in the "early onset" group and also in the group with "severe" disease, which was composed mainly of female patients. In the CD group, the frequency of the HLA antigens did not differ significantly from that in the control group.

Adult↗
PubMed1979

HLA system in relation to carbohydrate metabolism in lichen planus.

HLA antigens were determined in a group of fifty-two patients with lichen planus. In the group as a whole the frequency of A28 was increased but not significantly so. When the patients were subdivided according to the results of an oral glucose tolerance test, however, a highly significant increase in the frequency of A28 was found among the non-diabetic patients.

Adolescent↗
PubMed1979

HLA antigens in genetic neutropenia of Yemenite Jews.

The HLA antigenic system was studied in Yemenite Jews with genetic neutropenia. No deviation in antigen frequency was observed when compared with matched controls from the same ethnic group. HLA antigen frequency and common haplotypes of the Yemenite Jews were found entirely different from those of the African blacks, known to have the same anomaly.

Adult↗
PubMed1979

Cell-mediated immunity to polio and HLA antigens in amyotrophic lateral sclerosis.

Cell-mediated immunity to poliovirus was demonstrated in 21 of 33 patients suffering from amyotrophic lateral sclerosis (ALS), whereas no response to poliovirus was found in patients suffering from other neurologic disorders or in healthy controls. Three of the severe bulbar cases produced a migration inhibition factor (MIF) in the presence of poliovirus, although skin tests to common antigens were negative. An increased incidence (46 percent) of HLA-A3 was found in patients with amytrophic lateral sclerosis. Nine of the 13 patients with HLA-A3 antigen also had a positive index of MIF to poliovirus. These findings suggest a strong linkage between HLA-A3 and poliovirus in the pathogenesis of amyotrophic lateral sclerosis.

Adult↗
PubMed1979

Study of the HLA antigen in Arab children with paralytic poliomyelitis.

In 1974 and 1976, two outbreaks of paralytic poliomyelitis occurred in a vaccine-protected infant population in the Gaza Strip. To test the possibility of an increased susceptibility to the disease, the frequency of HLA antigens was studied in 58 of the affected children and compared with 113 control subjects. HLA-AW19 and -B7 were found more frequently in the affected children. These differences were not statistically significant but are consistent with the possibility that patients with the paralytic disease may have an HLA genetic makeup different from that of the rest of the population.

Child, Preschool↗
PubMed1979

HLA antigens in the Arab population of the Gaza Strip.

The HLA antigen system was studied in the Arab population of the Gaza Strip. The lymphocytes of 113 individuals were typed for 13 and 16 antigens at loci A and B, respectively. The distribution of the HLA antigens was found to be similar to that of an average Caucasoid Middle Eastern population. This was more marked when the tested population was compared with Arab populations living in northern Israel or originating from Lebanon, suggesting that they probably all share a common gene pool. The only noteworthy variation in the Gaza population was the high frequency of BW21, previously found only in Eritreans and Turks.

Gene Frequency↗
PubMed1978

HLA polymorphism in Israel. I. Jews of Polish extraction.

One hundred and twenty seven randomly selected Polish Jews were studied for their HLA polymorphism. Gene frequencies exceeding 0.1 were detected for A1, A2, Aw19, B14, Bw16 and Bw17. Significant gametic association was observed for (A1, Bw17), (A2, B27), (Aw26, Bw16), (Aw19, B13) and (A28, B14). Although a predominantly Caucasoid population, the Polish Jews show greater resemblance to Middle Eastern rather than to Northern European Caucasoids.

Gene Frequency↗
PubMed1978

HLA polymorphism in Israel. 2. Israeli Jews originating from Russia.

HLA typing of 123 Israel Jews of Russian origin showed a high frequency for HLA--A1, A2, Aw19 and B14, Bw16 and Bw35 of the A and B loci, respectively. The most frequently occuring haplotypes were (A1, B17), (Aw25, B18), (Aw26, Bw16), (Aw19, B13), (Aw23, B5) and (Aw25, Bw35). This study reveals a striking resemblance in the distribution of frequencies of HLA alleles and haplotypes between Russian Jews and two other East European Jewish communities (presented in this issue) of Polish and Rumanian origin.

Gene Frequency↗
PubMed1978

HLA polymorphism in Israel. 4. Israeli Jews originating from Rumania.

The frequencies of 29 HLA antigens of the A amd B loci were studied in 130 Israeli Jews originating from Rumania. The antigens A1, A2, Aw19 and B14, Bw16 and Bw35 occurred with the highest frequencies. The most common haplotypes were (A1, B17), (Aw26, Bw16) and (A28, Bw22). These results are similar to those observed in Polish and Russian Jews.

Gene Frequency↗
PubMed1978

HLA polymorphism in Israel. 5. The Moroccan Jews.

One hundred and forty one unrelated Moroccan Jews living in Israel were studied for their HLA polymorphism. Gene frequencies exceeding .1 were found for A1, A2, A3, Aw19, B5, B12, and B13. Significant linkage disequilibrium occurred for (A1, B8), (A2, B5), (A2, Bw21), (A3, Bw40), (A9, B7), (A10, Bw16), (A29, B18) and (Aw19, b14). they represent an intermediate population between Europe and the Middle East.

Gene Frequency↗
PubMed1978

HLA polymorphism in Israel. 7. The Babylonian Jews.

One hundred and twenty three Iraqi Jews, now living in Israel, were studied for their HLA polymorphism. Gene frequencies exceeding .1 were found for A1, A3, Aw19, B5, B12, and Bw35. A28, B8 and B14 were relatively rare whereas Aw25 and Bw37 were not found at all. Significant gametic associations occurred for (Aw23, Bw21), (Aw26, Bw16), (A11, B5), (A28, B8) and (A28, B7). The Iraqi Jewish population was found to be typical of Asiatics and Middle Easterners.

Gene Frequency↗
PubMed1978

HLA polymorphism in Israel. 9. An overall comparative analysis.

HLA gene frequencies in 11 Israeli populations and nine other relevant populations were used to calculate genetic distances in a quantitative assessment of their similarities and differences. The shortest distance found is between Polish and Rumanian Jews, while the largest is between Russian Jews and Black Africans. Estimates of "average" distances within major population groups suggest that the Ashkenazi Jews (Poles, Russians, Rumanians and Germans) are a more homogeneous population than East European non-Jews or than Middle-Eastern populations (Arabs, Armenians, Lebanese and Turks). A cline of distances between Ashkenazi Jews and other Jewish communities parallels their geographic distribution; however, the relatively large distance between the two North African communities (Libyans and Moroccans) demonstrates that geographic proximity is not necessarily correlated with genetic similarity. The Jewish populations, especially the Ashkenazi, show a clear divergence from their neighboring non-Jewish populations, among whom they have lived for many centuries. There are indications in the HLA data of a common origin for the diverse Jewish populations.

Gene Frequency↗
PubMed1978

Familial leukopenia among Yemenite Jews.

Benign familial leukopenia was found in 75 of 200 healthy Yemenite Jews examined. The leukopenia was not a constant finding and was not associated with a tendency toward infection. HLA typing showed no significant differences in the frequency of the various HLA antigens between the subjects with and without leukopenia. No similarity was found between the HLA of the Yemenite Jews with leukopenia and that reported in black Africans with benign familial leukopenia. The suggestion of a genetic contribution from African blacks to Yemenite Jews is not supported by these results. The question remains to be answered whether the familial leukopenia in Yemenite Jews and black Africans is the result of a mutation.

Adolescent↗