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Biomedical subjects

R Ziegler

Publications and source records attributed to R Ziegler.

At least 19 recordsLinked to original sources
PubMed1979

[Improvement of growth-hormone stimulation with l-dopa/l-carbidopa by simultaneous administration of propranolol (author's transl)].

The effect of simultaneous administration of 250 mg L-dopa + 25 mg L-carbidopa (Nacom) and 1 mg propranolol/kg body weight (maximal dose 40 mg propranolol) on growth-hormone secretion was tested in 96 children with growth retardation. The results were compared with those in a group of children that had been receiving only L-dopa and L-carbidopa. The additional administration of propranolol reduced the number of children unresponsive to adequate growth-hormone stimulation from 16% to 9.5%. There was no significant difference in mean maximal growth-hormone level between both groups, but the addition of propranolol caused a more long-lasting rise in serum growth hormone levels. Some of the children who previously had failed to have a satisfactory rise in growth-hormone level after L-dopa and L-carbidopa showed satisfactory stimulation when propranolol was added. Since only three blood samples need be taken (0, 45 and 90 minutes) and no significant side effects were noted, the combined treatment is suitable for out-patient use.

Carbidopa↗
PubMed1979

[The influence of primidone on thyroid function (author's transl)].

The influence of primidone on thyroxine level, T3 index, FT4 index, triiodothyronine level, T3 (RIA)/T4 (RIA) quotient as well as on the TSH basal and stimulated values was investigated in 30 children on long-term treatment. The values obtained were compared statistically with those of a normal group. During primidone treatment a drop in T4 level and in FT4 index as well as an increase in T3 (RIA)/T4 (RIA) quotient was observed. On the other hand the triiodothyronine level and the T3 index were not influenced. The TSH basal and stimulated values were not statistically different from the control group. Thus the primidone-treated children are euthyroid according to the TRH test. Primidone probably stimulates hepatocellular thyroxine breakdown.

Child↗
PubMed1979

The effect of (6-D-(O-TERT-B)-Ser)-gonadoliberin-(1--9) nonapeptide-ethylamide on gonadotropin release in prepubertal boys.

(6-D-(o-tert-B)-Ser)-gonadoliberin-(1--9) nonapeptide-ethylamine, (HOE 766), a highly active LH-RH analogue, was studied with regard to its effects on the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in 29 prepubertal boys given different doses (1 microgram, 2,5 microgram, 5 microgram or 7,5 microgram respectively). The effect of HOE 766 is dose dependent for FSH, but not for LH. There are important differences in the reaction of these young subjects from those of adults. Whereas LH levels barely rose, FSH secretion was superior to that seen in adults.

Child↗
PubMed1979

Radioimmunoassay for human parathyroid hormone for differentiation between patients with hypoparathyroidism, hyperparathyroidism and normals.

A RIA system for human PTH is presented using a goat antibody (Code name 017-spring-78) against C-terminal hPTH fragments, as well as a human PTH standard from hemodiafiltration of a hyperparathyroid patient. It proved to be useful for the differentiation not only between hyperparathyroid patients and normals, but even within the normal range and hypoparathyroid states.

Diagnosis, Differential↗
PubMed1979

Renal bone disorders in children: therapy with vitamin D3 or 1,25-dihydroxycholecalciferol.

Twelve children with chronic renal failure (CRF) and sixteen children receiving regular dialysis therapy (RDT) were treated with between 10,000 and 50,000 IU of vitamin D daily. This was associated with an increase in serum calcium levels and reduction in PTH levels. In the children with CRF, secondary hyperparathyroidism was improved with treatment but its development was not completely prevented nor was healing complete. In the patients receiving RDT, treatment with vitamin D improved the changes associated with secondary hyperparathyroidism in 50% of cases but these features sometimes reappeared despite continuing treatment. Hypercalcaemia or metastatic calcification was not seen. Subsequently, 1,25(OH)2D3 was administered to 14 children receiving RDT. This was associated with the return of serum calcium levels to normal, inhibition of PTH synthesis and an improvement in intestinal calcium absorption. Fibro-osteoclasia was cured and there was improvement in actual bone resorption. There was also improvement in osteoidosis in those children who showed disturbances of mineralisation. Calcification in the limbus area of the eyes may occur and hypercalcaemia was seen commonly. Treatment with 1,25(OH)2D3 should only be offered to children with severe renal bone disease. Neither vitamin D3 nor 1,25(OH)2D3 can guarantee complete recovery of osteodystrophy and of growth arrest in uraemic children.

Adolescent↗
PubMed1978

[Calcitonin therapy].

Explore the source record for details and available documents.

Arterial Occlusive Diseases↗
PubMed1978

Hypercalcitoninaemia in patients with pheochromocytoma.

As pheochromocytoma sometimes is accompanied by medullary thyroid carcinoma (in the sense of multiple endocrine adonomatosis type II = Sipple-Syndrome), serum calcitonin (CT) was measured by radioimmunoassay in 4 patients with pheochromocytoma. Before extirpation of the adreno-medullary tumor, serum CT was distinctly increased to 3 and 30 ng/ml in 2 of 4 patients, respectively. After removal of the tumor, serum CT was normal in the patients and pentagastrin stimulation produced no exaggerated CT response. In hydrochloric acid extracts from the two corresponding pheochromocytoma tissues, immunoreactive-Calcitonin (IR-CT) was detected, the concentrations amounting 1 and 4 ng/mg wet tissue. These findings suggest that hypercalcitonism in patients with pheochromocytoma cannot always be ascribed to the thyroid, i.e. increased calcitonin levels do not necessarily indicate a medullary carcinoma of this organ.

Adolescent↗
PubMed1978

A multimodal treatment approach for incarcerated alcoholics.

A multimodal milieu treatment approach for alcoholism was assessed in a prison setting by use of the MMPI. The participants had a mean age of 41, four prior incarcerations, and documented difficulty with alcohol abuse prior to their incarceration. Analysis of an A-B treatment design showed significant changes on the F, PT, ES (p less than .05), L, K, D, SI, and A (p less than .01) scales of the MMPI after 6 months of program participation. With the exception of the PD scale, all changes were seen as positive. It should be noted that the PD scale may not be the most appropriate indicator of positive behavioral changes in a prison setting.

Adult↗
PubMed1978

Interactions of calcium, magnesium and atropine on exocrine pancreatic secretion in man.

The effects of the intravenous administration of atropine or magnesium on pancreatic secretion which has been stimulated by secretin and induced hypercalcaemia have been studied in man. In the presence of secretin (0.5 CU/kg.h) the infusion of Ca2+ (0.3 mmol/kg.105 min) resulted in an increase in secretion of enzymes by 100-200%, and in that of Ca2+ and Mg2+ by 50-100% without affecting fluid and bicarbonate secretion. The additional injection of atropine (0.5 mg i.v. and 0.5 mg s.c.) were followed by a prompt fall in enzymes but not in Ca2+ and Mg2+ to the secretin-stimulated values. The additional infusion of Mg2+ (0.12 mmol/kg.45 min) to the Ca2+-infusion did not alter the secretion of enzymes, Ca2+ or Mg2+ compared with the calcium infusion alone. It is suggested that the hypercalcaemic stimulus depends on an intact innervation of the acinar cells. In these experiments the secretion of Ca2+ and Mg2+ seem to originate mainly from extracellular fluxes.

Adolescent↗
PubMed1978

[Gastric and exocrine pancreatic function in patients with medullary thyroid carcinoma and with bone diseases under treatment with calcitonin (author's transl)].

Calcitonin (CT) inhibits gastric acid and pancreatic enzyme secretion when infused intravenously. Therefore, in two patients showing excessively elevated CT-blood levels due to medullary thyroid carcinoma and in two patients with bone diseases before and under CT-treatment, gastric and pancreatic secretion were measured. Spontaneous (BAO) and pentagastrin stimulated acid as well as hormonally stimulated pancreatic enzyme secretion revealed normal in all subjects and tests. The findings are in favour of adaptation mechanisms of gastric parietal and pancreatic acinar cells against the inhibitory action of chronically elevated CT. Therefore, long term treatment with CT is no likely to induce impaired acidity or exocrine pancreatic insufficiency.

Adaptation, Physiological↗
PubMed1977

The effect of nacom (L-dopa and L-carbidopa) on growth hormone secretion in 75 patients with short stature.

The stimulatory effect of Nacom (250 mg L-Dopa and 25 mg L-Carbidopa) on the HGH secretion was evaluated in 75 short stature patients. The number of blood samples was restricted to only three (0, 45 and 90 min). 63 patients reached adequate HGH concentrations after the ingestion of 1 tablet Nacom (84%). Somatotropin levels increased from 2.08 (Sx 0.28) to a maximal HGH value of 14.22 (Sx 0.87) ng/ml. When the stimulatory effect of Nacom was compared with the standard method of arginine infusion in children with normal stature the arginine test was not superior to the Nacom-test. The Nacom-test appears to be a simple and reliable screening method for HGH deficiency, particularly in outpatients.

Adolescent↗
PubMed1977

[Paget's disease of bone: ultrastructure and cytogenesis of osteoclasts (author's transl)].

The cytogenesis of giant osteoclasts in Paget's disease of bone was studied by means of electron microscopy. 26 iliac crest biopsies were made and divided for light and electron microscopic investigation. A special procedure was used for electron microscopic preparation of bone without previous decalcification. Paget osteoclasts are characterized by their high content of nuclei. Several nuclei may show paracrystalline inclusions pointing to a possible virus infection of these cells. Giant osteoclasts have an increased mobility and a high resorptive activity, manifest by the dissection of bone fragments from endosteal bone surfaces. Cell membrane interdigitations between mononuclear cells and osteoclasts occur as a morphologic concomitant of cell fusion. Frequent occurence of such cell membrane contacts seem to indicate an increased tendency to cell fusion among the mononuclear precursors of Paget-osteoclasts. Precursor cells are located in the pericapillary region, and morphologically resemble pericytes. The assumption of an increased rate of cell fusion amoungst the precursor cells of osteoclasts might explain the development of giant osteoclasts in this disease. Further studies of the paracrystalline nuclear inclusions of Paget-osteoclasts are necessary to determine whether this process can be considered to be a cytopathogenic effect of virus infection.

Aged↗
PubMed1977

[First experience with the practical year in internal medicine (author's transl)].

The first experience with the training program carried out in the University of Ulm presents a number of problems which could be important for its realization in teaching hospitals. The seminar and course program should be related to practice and be organized with the active cooperation of the students. The quality of the training to a great extent depends on the didactic skill, willingness to teach and a not inconsiderable expense of time for the chief physician, the assistant chief physician and the physician in charge of the wards during visits and when working in the ward. The omission of the "Junior Intern" status seems to be a disadvantage to the teaching organization. Condensing the seminar sessions into one month in a three-month period is possibly a logical compromise to guarantee the necessary continuity of the ward work and additional theoretical preparation for the final examination which the student requires.

Education, Medical, Undergraduate↗