[An integrated geriatric entity].
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Biomedical subjects
R Zutter
Publications and source records attributed to R Zutter.
[Goals and limits of partial hospitalization in geriatrics. 10 years of day-care hospitals].
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Potency of two rabies vaccines in cats as determined by antibody assay and virulent virus challenge.
The persistence of immunity induced by a modified live virus rabies vaccine (SAD strain) and an inactivated rabies vaccine combined with panleukopenia vaccine in cats was studied serologically and by virulent rabies virus challenge. The source of challenge virus was a suspension of a dog salivary gland. All 16 cats vaccinated with the inactivated vaccine developed high antibody titres and 15 were protected against the virus challenge. All 8 cats vaccinated with the MLV vaccine produced a serological immune response but 5 cats were not protected against the virus challenge. Some reasons for this phenomenon are discussed.
Animals↗
Potency testing of inactivated rabies vaccines in mice, dogs and cats.
The high variability that exists in the NIH potency test for inactivated rabies vaccines is well known. To control this variability, the use of a reference preparation of rabies vaccine in parallel with the test vaccines is recommended. However, our data indicate, that the NIH test is more variable when calculating antigenic values using the reference vaccine CRV1 than when calculating only PD50 values. We immunized the mice with a single dose of different vaccine dilutions. As our results suggest, the antibody assay in immunized mice used for the NIH test, seems to be the best possible manner to determine the potency of inactivated rabies vaccines. The antigenic value of the NIH test does not correlate with the antibody status in immunized cats and dogs, but a correlation between antibody titres in mice and dogs appears to exist.
Animals↗