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R von Lohr

Publications and source records attributed to R von Lohr.

4 recordsLinked to original sources
PubMed1984

[Active immunization against hepatitis B].

The efficacy of the hepatitis B vaccine Hevac B Pasteur was assessed in 277 persons over a period of 6 months. HBs antigen of 5 micrograms/dose was administered three times in monthly intervals. Before each vaccination and after 6 months 18 chemical pathology data and a clinical assessment were performed and all important serologic hepatitis markers (anti-HBs, anti-HBc, HBs antigen, HBc antigen, anti-HBe) were determined radioimmunologically. Within two months antibodies against the surface antigen (anti-HBs) had developed in 85.7% of vaccinees. After 6 months 93.1% of vaccines had become seropositive. Within the first two months anti-HBs-positive findings and higher anti-HBs concentrations occurred significantly more frequently (P less than 0.048) in females than in males. These differences had largely disappeared at the follow-up assessment in the sixth month. In contrast, both parameters (seroconversion rate and anti-HBs concentration) were age-dependent. Among vaccines of less than 25 years of age and of more than 35 there were significant differences after 6 months (P less than 0.005). The hepatitis B vaccine of the Pasteur institute can be considered immunogenic and safe.

Adult↗
PubMed1984

[Viral hepatitis B markers in physicians and medical personnel in the Rhein-Main region].

HBs antigen, anti HBs and anti HBc were determined radioimmunologically on 314 medical students, 585 doctors, 151 medical laboratory personnel and 307 nursing staff. Hepatitis B markers were present in 5.1% of medical students, 23.4% of doctors, 17.9% of laboratory personnel and 18.6% nursing staff. In the different groups there were up to 1.3% HBs antigen-positive persons. A large majority of persons with signs of previous hepatitis B infection had concentrations of both antibodies (anti-HBs and anti-HBc). Between 0.6 and 5.5% of persons were merely anti-HBc positive. Among doctors the number of positive results increased with age and professional exposure, no age dependence as to seropositive or seronegative being found in the other groups. None of the persons tested had been aware of a preceding hepatitis infection. These results indicate that doctors and medical personnel even today are at risk of an undetected viral hepatitis B.

Adult↗