Biomedical subjects

Radosław Rózycki

Publications and source records attributed to Radosław Rózycki.

8 recordsLinked to original sources

PubMed2005

[A 0,05% cyclosporine treatment of the advanced dry eye syndrome].

PURPOSE: The purpose of our study has been to present the results obtained from the treatment with 0.05% cyclosporine solution in drops in patients with severe aggravation of dry eye syndrome manifestations who otherwise did not suffer from any systemic disease (a three-month treatment). Another group in whom we used the same treatment were those who suffered from dry eye syndrome, which developed in the course of Sjogren's syndrome, and graft versus host disease following bone marrow transplantation (a six-month treatment). MATERIAL AND METHODS: The study comprised 15 dry eye syndrome patients (30 eyes), who were divided into three groups. In Group I were those with severe aggravation of dry eye syndrome manifestations without concomitant systemic diseases (3 women), aged 54 to 59 years (mean 57). Group II comprised the patients with Sjogren's syndrome (8 women, 1 man), aged 45 to 59 years (mean 55.5) with graft versus host disease. In Group III, there were 3 women, aged 52 to 59 years (mean 55) with graft versus host disease. All the patients were administered 0.05% cyclosporine topically twice daily. The Group I patients were given 0.05% cyclosporine solution for 3 months, those in Groups II and III for 6 months. Subjective complaints were classified according to the protocol of Dr. Mann Pharma/Bausch & Lomb. RESULTS: The effectiveness of the therapy with 0.05% cyclosporine solution was evaluated by the mean number of points in a five-point Schirmer II test score, measured before and after the treatment. The Group I patients (dry eye syndrome without systemic diseases) were found to have the highest mean number of points - 4. In the Sjogren's syndrome Group, the mean number of points was 3.1; and in Group III (graft vs host disease) the mean value was 2 points. Since the number of patients was different in particular groups, the findings have not been compared between themselves. CONCLUSIONS: Using 0.05% cyclosporine solution is effective in treating patients with dry eye syndrome but without systemic diseases. In such cases a short, three-month treatment is sufficient. The 0.05% cyclosporine treatment is just as effective in patients with dry eye syndrome and Sjogren's syndrome or graft versus host disease. Yet in such cases the treatment has to be longer and take six months. We observed a mean increase points in the five-point Schirmer II test score in all our patients.

Administration, Topical↗

PubMed2005

[Evaluation of the medial canthus blepharoplasty using the lazy-T method].

PURPOSE: To evaluate the efficacy of surgical "Lazy-T" method used to correct ectropion of the lower punctum with the inferior lid laxity and the medial canthal tendon. METHOD AND MATERIAL: Between January 2004 and February 2005, four patients of mean age 67 years (+/-12) were operated with this method. In two patients, one eyelid was operated; the other two patients underwent bilateral lid surgery. Preoperative qualifications included: subjective assessment of epiphora (range 0-10 points), where 0 represents loss of epiphora and 10 points maximum intensification with ectropion of the lower punctum, laxity of the inferior eyelid more than 10 mm, and laxity of the medial canthal tendon of 2-nd degree or more. Two subjects, who expressed their consent, underwent lacrimal scintigraphy. Surgical technique included excise of the middle part of the lid at its full thickness, laterally from lower punctum, and correction of the conjunctiva. The follow-up period was 6 months on average. RESULTS: All patients reported reduction of epiphora of 5 points on the average. Eyelid laxity decreased by mean 4.5 mm (+/- 1.0 mm). In two patients epiphora regressed, in two others - decreased. All patients evaluated the cosmetic result as satisfactory. CONCLUSIONS: The "Lazy-T" correction is an effective procedure, which restores the lower punctum into its normal anatomical position. It is a simple surgical technique that can free patients from epiphora.

Aged↗

PubMed2005

[The usefulness of thermography in the diagnostics of dry eye syndrome].

PURPOSE: The aim of the study was to evaluate corneal temperature in patients with dry eye syndrome, and in normal subjects by measuring with infrared radiation thermography. MATERIAL AND METHODS: Each eye of 9 patients with dry eye syndrome and each eye of 13 normal subjects, were evaluated in this study. The corneal surface temperature was measured during 15 seconds after opening the eye. RESULTS: Mean corneal temperature was lower in the dry eye syndrome patients compared with the control group. Decrease in time of mean corneal temperature in patients with dry eye syndrome, was lesser than in the control group. CONCLUSIONS: The study shows the usefulness of thermography in the diagnosis of dry eye syndrome.

Adult↗

PubMed2004

[Mycotic lacrimal canaliculitis--cases report].

Mycotic lacrimal canaliculitis is a rare eye disease. Overuse of antibiotics and steroids in the treatment of eye infections is a very serious risk factor. Initial diagnosis of the mycotic infection may be difficult, thus infection may lasts for months. Chronic conjunctivitis, itching, burning sensations, poor response to the treatment may suggest a suspicion of the mycosis. In our paper we report two cases of the mycotic lacrimal canaliculitis, diagnosis and treatment. We could not culture fungal colonies, but we have found fungal structures in direct microscopic detection during the examination of deposits found in the canaliculi. In our opinion it is important to consider fungal infections during the treatment of chronic eye disorders.

Actinomycosis↗

PubMed2004

[Immunological phenomenons in the pathology of the tear film. Is cyclosporine the turn point in the Sjögren's syndrome treatment? Preliminary report].

PURPOSE: The purpose of this study is to examine the new way in the casual treatment, resulting in the normalization of immunological processes on the ocular surface. MATERIAL AND METHODS: 5 patients (4 women and 1 men with mean age of 55.5 years, range 45 to 59 years) with Sjögren's syndrome--type dry eye, were included in the study. Patients received topically 0.05% cyclosporine, ophthalmic emulsion twice a day for a 6 months. The severity of patients complaints was evaluated according to the Dr. Mann Pharma/Bausch & Lomb's record. RESULTS: Schirmer test II values, and lyzamine green staining scores, were evaluated priori to treatment and 6 months after the start. At the beginning of the study (day 0) the Schirmer test II values ranged from 1 to 5 mm (mean--2.2 mm). Break-up-time ranged from 3 to 6 sec (mean--4.8 sec). In all of 5 cases lyzamine green staining scores were 9. On month 6th, all of 5 patients had significant differences, compared to their baseline measurements in term of above mentioned parameters. The Schirmer test II values ranged from 8 to 12 mm (mean--10.3 mm). Break-up-time ranged from 9 to 13 sec (mean--11.2 sec), lyzamine green staining scores ranged from 2 to 3 points (mean--2.7). CONCLUSIONS: 0.05% cyclosporine, ophthalmic emulsion had a beneficial effect both on the subjective and objective clinical parameters of dry eye patients. The final conclusions must be supported by more cases.

Cyclosporine↗

PubMed2004

[Surgical treatment of posttraumatic lower canaliculus interruption and results of treatment estimation].

The authors present the method of surgical treatment of posttraumatic lower canaliculus interruption using intubation through upper lacrimal canaliculus. The lacrimal system was intubated through the upper lacrimal canaliculus with a silicone drainage system for 6 weeks. The results were estimated on a base of dacrocystography and scyntygraphy of lacrimal system after 6 month. The presented surgical treatment is both easy for a beginning surgeon and brings good functional results.

Adult↗

PubMed2003

[Surgery for involutional ectropion--case report].

In this paper authors described methods of surgery in involutional ectropion, surgical anatomy and changes in the lower eyelid due to aging. The surgical treatment of advanced involutional ectropion and its results is presented.

Aged↗

PubMed2002

[Dacryocystography and dacryoscintigraphy in diagnosis of naso-lacrimal duct obstruction].

PURPOSE: To find the right diagnostic test through checking the drainage of lacrimal ducts. MATERIAL AND METHODS: Dacryocystography of lacrimal ducts was performed in 25 patients by using 0.5-1 ml of Lipidiol and conducting X rays in different head positions--3-4 photograph in A-P projection (exposition's parameters 85-90 kV and 12-15 mAs, distance lamp-table: 100-130 cm, Philips Diagnose 93). For stereo estimation--2 oblique photographs of head, deviated at 45 towards central body line. Patient is brought on vertical position and after 5 minutes radiography in A--P projection can show remaining contrast in lacrimal duct. Dacroscintigraphy was done in 200 patients by dropping in conjunctival sac 1 drop of sterile 99mTc, in dose 3.7-7.4 MBq (100-200 uCi). The patients head is immobilized on the support, close to detection head of gamma camera (ediso Nucline TH) with LEHR. Distribution of this drug was visible on the monitor and saved in the computer's memory. Data was registered during 10 minutes, summed up into end picture and then evaluated by sight. RESULTS: Many authors consider dacryoscintigraphy and dacryocystography as methods of choice in establishing correct diagnosis. High sensitiveness and mutual completion of both methods lets us quickly explain the reasons of epiphora and settle further management.

Aged↗