Biomedical subjects

Rafał Celiński

Publications and source records attributed to Rafał Celiński.

4 recordsLinked to original sources

PubMed2005

[Relationship between plasma brain natriuretic peptide level and left ventricular systolic function in coronary artery disease].

UNLABELLED: THE AIM of the study was to assess the brain natriuretic peptide (BNP) plasma concentrations in patients with CAD and to evaluate the relationships between BNP levels and such parameters of the left ventricular (LV) systolic function as ejection fraction (LVEF) and peak LV emptying rates (PER). MATERIAL AND METHODS: The study population comprised 69 patients with CAD, aged 30-79 years. All subjects underwent gated equilibrium radionuclide ventriculography at rest. From the data acquired, LVEF and PER were calculated. The plasma BNP concentrations were determined in blood samples taken from patients with CAD and in 18 healthy subjects and the obtained results were compared with those by radionuclide ventriculography. For this purpose patients with CAD were divided into two subgroups: dLVEF (LVEF<50%) and nLVEF (LVEF>50%). Subjects with normal LVEF (nLVEF) were divided into subgroups with PER greater than median value of this parameter and lower than or equal to the median. RESULTS: In patients with CAD both the BNP concentration and its frequency were significantly higher than in controls. In patients with CAD and dLVEF the BNP concentration was significantly higher than in nLVEF cases. Increased BNP concentration was distinctly more frequent in dLVEF group than in nLVEF, but the difference was not significant (p>0.05). In group with nLVEF, the BNP concentration was higher in patients with PER<2.33 (dPER) in comparison to those with PER>2.3 (p>0.05). Not very close, but statistically significant correlation was found between the BNP level on the one hand and the LVEF and PER on the other. CONCLUSIONS: Increased plasma BNP in patients with CAD seem to depend not only on the degree of the myocardial contraction, but also on the dynamics of the left ventricular emptying. The reason for the BNP elevation in cases with CAD and reduced LV ejection rate but normal EF needs to be investigated.

Adult↗

PubMed2004

Relationship between plasma BNP levels and left ventricular diastolic function as measured by radionuclide ventriculography in patients with coronary artery disease.

BACKGROUND: Radionuclide ventriculography enables such parameters of the left ventricular (LV) function as the ejection fraction (EF), ejection rate (ER) and filling rate (FR) to be measured correctly. The impairment of the LV function in coronary artery disease (CAD) results in an increase in plasma brain natriuretic peptide (BNP). The aim of this study was to check whether the reduction of the average filling rate (AFR) leads to an increase in plasma BNP levels in patients with CAD and nEF and whether that increase is comparable to that occurring in subjects with a reduced PER. MATERIAL AND METHODS: The study population comprised 69 patients with CAD and 18 healthy subjects--a control group (CG). In all cases radionuclide ventriculography was performed at rest and the plasma BNP level was estimated. RESULTS: The plasma BNP concentration was significantly higher in the group with CAD than in those with CG . In patients with CAD and a decreased LVEF (dEF), the BNP level was significantly higher than in those with normal LVEF (nEF). In the subgroup with nEF and an AFR < or = 1.04 EDV/s, the level of plasma BNP was significantly higher than in that with an AFR >1.04. In the total CAD group, a significant correlation was found between plasma BNP concentrations and the LVEF, PER and AFR. In patients with nEF, the level of plasma BNP correlated only with the AFR. CONCLUSIONS: It is concluded that the diastolic dysfunction of the left ventricle in patients with CAD leads to an elevation of plasma BNP concentrations despite the normal ejection fraction. A diastolic dysfunction of the left ventricle affects the BNP plasma concentration to a greater degree than a systolic dysfunction.

Adult↗

PubMedDate not supplied

[Fatal poisoning due to narcotic abuse in the analytic-toxicological practice of Forensic Medicine Department Silesian Medical Academy in Katowice in years 1996-202].

147 cases of fatal poisonings in people due to narcotic abuse examined in the Forensic Medicine Department Silesian School of Medicine, Katowice in the years 1996-2002 have been presented in the paper. In the group examined there were 126 males and 21 females at the age of 16-44. Opium narcotics were found in 139 out of 147 cases and amphetamine derivatives in 18. Opiates were indicated in 58 individuals and amphetamine only in 8. In 35 poisoned people opiates with barbituric acid derivatives were found. In 3 cases death resulted after taking opiates and amphetamine derivatives. 1 individual died after taking opiates and substances of the phenothiazine group. In the organic fluids of 18 people opiates and medicines being derivatives of 1,4-benzodiazepine and barbituric acid were found. Amphetamine and derivatives of 1,4-benzodiazepine were found in 6 individuals and opiates, barbiturates, benzodiazepines and amphetamine in 1 individual. Concentrations of all the substances indicated ranged widely and were as follows: < 0.10-17.40 > microgram/ml for opiates; < 0.24-30.00 > microgram/ml for amphetamine; < 0.12-1.90 > microgram/ml for 1.4-benzodiazepine derivatives and < 0.18-15.24 > microgram/ml for barbituric acid derivatives. Ethanol was found in 18 individuals and its concentration was < 0.2-2.5 >@1000.

Adolescent↗

PubMedDate not supplied

[Analytical problems in examination of small amounts of blood samples taken from law offenders].

In the paper there have presented results of the analysis of small blood samples taken routinely from 3 cases after car accidents and 1 rapist. Fluorescence polarisation immunoassay (FPIA, Abott) was used for screening examinations of narcotics from the group of both opium and cocaine alkaloids, barbituric acid and benzodiazepine and also drugs from the group of tricyclic antidepressants. Confirmation of the obtained results and full identification of the substances analysed were carried out by liquid chromatography with mass spectrometry (LC-MS). In the causes of car accidents components of "compote" were found (poppy straw extract) morphine and codeine (1 case), cocaine (1 case) and also tramadol and diazepam (1 case) were also found. In the rapist methylenedioxymethamphetamine (MDMA) was determined.

Accidents, Traffic↗