Cardiopulmonary bypass in sickle cell disease.
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Anemia, Sickle Cell↗
Biomedical subjects
Rajeshwar Sharma
Publications and source records attributed to Rajeshwar Sharma.
Left ventricle rupture after mitral valve replacement.
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Heart Injuries↗
Interactions of aflatoxin B1 with SRP components can disrupt protein targeting.
Spectrofluorimetric studies have revealed that aflatoxin B1 (AFB1) interacts with signal recognition particle (SRP), which acts as an escort for polyribosomes with signal peptides to be transported and bound to the cytoplasmic face of the endoplasmic reticulum (ER). We further report that the binding of AFB1 to SRP is selective as it only binds to two (SRP9 and 14) out of its three constituent polypeptides studied. Binding of AFB1 to proteins is known to alter their conformations. Interactions of AFB1 with SRP polypeptides may generate structural and functional alterations in this particle and hinder secretory protein synthesis.
Aflatoxin B1↗