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Biomedical subjects

Rajiswamy

Publications and source records attributed to Rajiswamy.

4 recordsLinked to original sources
PubMed1978

Michaelis-Menten constant of serum aspartate amino transferase (AST) in heart and liver diseases.

The activity and the Km (Michaelis-Menten constant) of serum aspartate amino transferase (AST) were investigated in normal subjects, in patients with recent myocardial infarction, and in patients with infectious hepatitis. AST activity was elevated in both groups of patients. While the Km value of serum AST was not affected in myocardial infarction, it was increased in infectious hepatitis when the total serum bilirubin was higher than 13 mg/dl. Thus, while an investigation of activity of AST in serum did not help in differential diagnosis of heart and liver diseases, determination of Km value was helpful in the diagnosis of infectious hepatitis.

Alkaline Phosphatase↗
PubMedDate not supplied

Hydrogen peroxide release by OKIa1 (anti DR--monoclonal antibody) resistant alveolar macrophages in tuberculosis.

Phorbol myristate acetate (PMA) triggered hydrogen peroxide (H2O2) release from alveolar macrophages and corresponding blood monocytes were studied as a whole, in active tuberculosis, inactive tuberculosis (treated), non-tuberculous lung disease patients and normal individuals. Irrespective of the study subjects, the alveolar macrophages produced less H2O2 than the corresponding blood monocytes. The alveolar macrophages that were resistant to OKIa1 (Anti-DR monoclonal antibody and complement treatment) produced an increased level of H2O2 than the control ascites and complement treated alveolar macrophages. Moreover, such increase in H2O2 release was not seen with peripheral blood monocytes; more than 90% monocytes were OKIa1 resistant population. These OKIa1 resistant alveolar macrophages are probably important in their metabolic, microbicidal and the immunological functions.

Antibodies, Monoclonal↗