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Biomedical subjects

Rana Olguntürk

Publications and source records attributed to Rana Olguntürk.

12 recordsLinked to original sources
PubMed2005

Distribution of syncopal episodes in children and adolescents with neurally mediated cardiac syncope through the day.

AIMS: To assess the relation between the timing of syncopal attacks and tilt test positivity. METHOD AND RESULTS: Prospective comparisons of distribution of syncopal attacks in 49 consecutive neurally mediated cardiac syncope (NMCS) patients (19 boys, 30 girls, mean age 13.7+/-0.68) were evaluated. Head-up tilt test (HUT) was positive in 28 patients and negative in 21. A questionnaire was given to every patient about the time and number of the syncopal attacks, presyncopal symptoms or signs before HUT. Although syncopal attacks were found to be concentrated in the morning especially between 10 AM and 12 noon in HUT positive patients (P < 0.001), there was a concentration in the late afternoon and evening period of the day especially between 2 PM and 6 PM in HUT negative patients (P < 0.001). CONCLUSION: It was assumed that diurnal variation in autonomic function may be the factor in the timing of syncopal events during morning hours in the HUT positive NMCS children and adolescents.

Adolescent↗
PubMed2005

Two unusual presentations of acute rheumatic fever.

Patients with acute rheumatic fever sometimes present with atypical signs and symptoms. In these circumstances, the Jones criterions may not be sufficient to make a clinical diagnosis. We describe here two patients with unusual presentations, highlighting that, both in regions where the disease is endemic, or where it is seen only sporadically, physicians should be more alert and careful in making the diagnosis.

Abdominal Pain↗
PubMed2004

Effective regurgitant orifice area of rheumatic mitral insufficiency: response to angiotensin converting enzyme inhibitor treatment.

OBJECTIVE: This study was designed for quantification of mitral regurgitation by echocardiographic measurements such as regurgitant volume (RV), regurgitant fraction (RF) and effective regurgitant orifice area (EROA), and to assess the effect of angiotensin converting enzyme inhibitor (ACEI) therapy on these measurements. METHODS: Patients with rheumatic mitral insufficiency were divided into two groups: Study group (SG)-10 females, 2 males, aged 10-18 years, body surface area 1.49+/-0.05 m2, receiving digoxin therapy for at least one year and Control group (CG)-8 females, 4 males, aged 8-17 years, body surface area 1.38+/-0.07 m2, with no treatment. Patients in the two groups had no symptoms of cardiac failure. Angiotensin converting enzyme inhibitor therapy was given to SG patients on admission. Echocardiographic examinations were applied on admission and at the 20th day of therapy with ACEI and digoxin. RESULTS: Study group's left ventricular end-diastolic volume (108.03+/-41.21 ml/m2), mitral stroke volume (510.37+/-321.58 ml/m2) and regurgitant volume (423.48+/-305.00 ml/m2) were significantly higher (p<0.05) on admission than in the CG (81.98+/-21.53 ml/m2, 315.34+/-207.38 ml/m2 and 245.77+/-179.84 ml/m2, respectively). Aortic stroke volume at the 20th day of therapy was significantly higher in SG than in the CG. Therapy with ACEI decreased significantly SG's left ventricular end-diastolic volume. CONCLUSION: Angiotensin converting enzyme inhibitors should be started at an early stage of mitral regurgitation. The effective regurgitant orifice area is a feasible and easy method for the outpatient follow-up of mitral regurgitation.

Administration, Oral↗
PubMed2003

Abnormality of the left ventricular sympathetic nervous function assessed by I-123 metaiodobenzylguanidine imaging in pediatric patients with neurocardiogenic syncope.

The purpose of this study was to assess the left ventricular sympathetic nervous system function in the patients with neurocardiogenic syncope (NCS) using I-123 metaiodobenzylguanidine (MIBG) imaging of the heart, and to compare the plasma noradrenaline (NA) and MIBG results of tilt positive and tilt negative patients following a head-up tilt test (HUT). The study included 30 patients. Their physical and laboratory examinations did not show a pathology that may be the cause of their syncope. HUT test was positive in 13 patients and negative in 17 patients. Plasma NA concentrations were higher in the HUT positive than the HUT negative group at the beginning and at the 10th minute of the test. Specific I-123 MIBG uptake assessed as the cardiac to mediastinal activity ratio in the delayed image was significantly higher in HUT positive group. The higher levels of MIBG uptake and plasma NA observed in HUT positive patients may reflect the greater capacity of NA storage in cardiac adrenergic neuronal tissue in patients with NCS. The results of this study support the critical role of autonomic nervous system in the pathophysiology of NCS and the excessive sympathetic nervous stimulation as the trigger of paradox reflex.

3-Iodobenzylguanidine↗
PubMedDate not supplied

Noncompaction with arcus aorta anomalies.

An 18-month-old girl with tetralogy of Fallot (TOF), mental retardation and multiple infarcts on brain computerized tomography (CT) is presented. Her sineangiocardiograms showed a thrombus (moving from the left ventricle to ascending and abdominal aorta), TOF, right arcus aorta with anomalous origin of left subclavian artery from the descending aorta, honeycombed appearance of the apex and half of the posterior wall of left ventricle and the apex of right ventricle. Her echocardiography (ECHO) examinations revealed depressed left ventricular systolic function and thrombus in the left ventricle apex, with noncompaction of the left ventricle apex and the middle portion of posterior wall, and in the right ventricular apex.

Brain↗