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Randall Olson

Publications and source records attributed to Randall Olson.

4 recordsLinked to original sources

A light adjustable lens with injectable optics.

The light adjustable lens (LAL) is an innovative intraocular lens optic composed of partially polymerized macromers with an appropriately bonded photosensitizer. The injectable technology and multifocality associated with the LAL can produce precise refractive correction and, it is hoped, the type of accommodative range that is taken for granted during youth. Combining these technologies with a lens material that behaves like the crystalline lens of 25-year-old could precisely return near and distance vision to older adults.

Accommodation, Ocular↗

A light adjustable lens with injectable optics.

PURPOSE OF REVIEW: Technology exists today that could permit refractive precision unheard of at the present time plus the correction of higher-order aberrations and restoration of accommodation in presbyopic adults. RECENT FINDINGS: With the light adjustable lens, after surgery, the shape of the lens can be customized to treat spherical, cylindrical and other higher-order aberrations. The posterior surface of the lens can be adjusted to create both refractive multifocality and diffractive bifocality. It can be made out of a variety of materials, some of which can be injected into the capsule, filling it, thus replicating the original shape of a crystalline lens. While the current technique of bag filling does permit the less viscous materials to leak out of the bag this is a solvable problem. For example, a disc can fill an ordinary-sized capsulorrhexis opening, allowing removal of the cataract using standard techniques and filling behind this disc. Also the material, once injected, could be polymerized. Posterior capsule opacification is also potentially solvable with devices that completely destroy lens epithelial cells or through a polymerization process of the new lens material in which the reaction destroys the capsular cells and actually binds to the capsule. SUMMARY: It is apparent that light adjustable lenses plus injectable technology, and multifocality can produce precise refractive correction and, hopefully, the type of accommodative range that we take for granted when we are young. Combining these technologies with a lens material that behaves like a crystalline lens of a 25 year old could precisely return near and distance vision to older adults.

Accommodation, Ocular↗

Late postoperative opacification of MemoryLens hydrophilic acrylic intraocular lenses: case series and review.

PURPOSE: To report clinical and spectrographic analyses of 2 explanted hydrophilic acrylic intraocular lenses (IOLs). SETTING: John A. Moran Eye Center, Salt Lake City, Utah, USA, and Johannes Gutenberg-University, Department of Ophthalmology, Mainz, Germany. METHODS: We report 6 cases of opacification of MemoryLens IOLs (Ciba Vision) that occurred approximately 2 years after implantation. The anterior and posterior surfaces of the IOLs had a white, frosted appearance, and the IOLs' interior looked brown, similar to the appearance of a brunescent cataract. Two of the IOLs were explanted because of a significant decrease in visual acuity. The IOLs were sent for further clinicopathologic analysis including scanning electron microscopy and energy dispersive x-ray spectroscopy (EDX). RESULTS: Microscopic analysis revealed multiple, fine, granular deposits of various sizes on the surface of the lens optics. The EDX analysis showed the presence of calcium within the deposits. CONCLUSIONS: Our cases show that hydrophilic acrylic IOLs can opacify even years after implantation. Analysis of the explanted IOLs revealed calcification.

Acrylic Resins↗