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Biomedical subjects

Randolph E Regal

Publications and source records attributed to Randolph E Regal.

9 recordsLinked to original sources
PubMed2006

Acid suppressive therapy use on an inpatient internal medicine service.

BACKGROUND: Use of acid suppressant medications has increased in both frequency and breadth in recent years. Data have indicated that questionable use of acid suppressants for non-accepted indications is common. OBJECTIVE: To assess the indications and prevalence of acid suppressants used by inpatients on admission and at discharge. METHODS: A retrospective chart review of 213 patients admitted to the University of Michigan Hospital non-critical care general medical service was conducted. Relevant medical history, acid suppressant drug used, and indications were collected from both inpatient medical records and discharge medication lists. RESULTS: Of the 213 patients reviewed, 29% were taking acid suppressants prior to admission, with 33% being proton pump inhibitors (PPIs). Once patients were admitted, acid suppressant use increased to 71% (152 of 213), with 84% PPIs, 11% histamine(2)-receptor antagonists, and 5% combination therapy. Based upon our criteria, only 10% (15 of 152) of those on acid suppressants were found to have an acceptable indication. In patients where any history of gastroesophageal reflux disorder (GERD) was deemed as an acceptable indication (32 other patients), 31% (47 of 152) had an acceptable indication. For the 137 patients with non-accepted indications, 29% had no discernable indication and 38% were prescribed acid suppressants for corticosteroid-associated or stress ulcer prophylaxis. A history of gastrointestinal bleeds or peptic ulcer disease of more than 3 months since initial diagnosis or documented exacerbation of symptoms comprised 8% of the population. The aforementioned group of GERD patients made up 23% of this group. Compared to the 29% of patients taking acid suppressants prior to admission, 54% (115 of 213) of patients were prescribed acid suppressants at discharge. If only recent exacerbations of GERD were deemed as long-term indications, 10% (12 of 115) of these patients were found to have accepted indications. If all GERDs were acceptable long-term indications, 27% (31 of 115) would have met criteria for acceptable outpatient use. CONCLUSIONS: There is considerable excess usage of acid suppressants in both the inpatient and outpatient settings.

Adult↗
PubMed2006

Antibiotic allergy.

Explore the source record for details and available documents.

Anti-Bacterial Agents↗
PubMed2006

Urinary tract infections in extended care facilities: preventive management strategies.

OBJECTIVE: To provide health care professionals with an overview of interventions that may be done to reduce the incidence of urinary tract infections (UTIs) in elderly patients, especially those residing in extended care facilities. DATA SOURCES: A Medline search of the English literature was performed from 1980 to January 2006 to find literature relevant to urinary tract prophylaxis. Further references were hand-searched from relevant sources. STUDY SELECTION: When assessing the effectiveness of various clinical interventions for reducing the incidence of UTIs in the elderly, preference was given to more recent, double-blind, placebo-controlled randomized studies, but studies of less robust design also were included in the discussions when the former were lacking. DATA EXTRACTION: Where possible, recent publications were favored over older studies. References were all reviewed by the authors and chosen to present key citations. DATA SYNTHESIS: Data selection was prioritized to address specific subtopics. CONCLUSION: Though still frequent in occurrence and quite costly in terms of morbidity, mortality, and cost to the health care system, numerous measures may be taken to ameliorate the incidence of UTIs in elderly, institutionalized residents. First and foremost, establishing and adhering to good infection-control practices by health care givers and minimizing the use of indwelling catheters are essential. Adequate staffing and training are germane to this effort. Reasonably well-designed clinical studies also give credence to the use of topical estrogens and lactobacillus "probiotics" for female subgroups and cranberry juice for a wider array of patients. Vitamin C is of no proven benefit. With regard to antibiotics, with the relative paucity of data available for this patient population, concerns for resistance proliferation must be balanced against perceived gains in UTI reduction.

Anti-Bacterial Agents↗
PubMed2005

Medication use as a risk factor for falls among hospitalized elderly patients.

PURPOSE: The relationship between medication use and falls among hospitalized elderly patients was studied. METHODS: Sixty-two patients 65 years of age or older who fell during hospitalization were randomly selected from incident reports of falls and matched for age, sex, and discharge date with 62 patients who did not fall. Data on demographic characteristics, vital signs, laboratory test variables, drug therapy, and the presence of other known risk factors for falls were collected retrospectively and compared between the groups. RESULTS: Nonsteroidal antiinflammatory drug (NSAID) use was more frequent in patients who fell than in control patients. NSAID use was a significant predictor of falls and was associated with a 10-fold increase in the likelihood of falling. Opioid analgesics were given more frequently to control patients and were not associated with falls. Dementia, the only non-medication-related independent predicator of falls, was associated with a 21-fold greater risk of falling. CONCLUSION: In hospitalized elderly patients, there was a significant association between NSAID use and falls, an effect largely accounted for by low-dose aspirin.

Accidental Falls↗
PubMed2004

Incidence of carbapenem-associated allergic-type reactions among patients with versus patients without a reported penicillin allergy.

This retrospective analysis sought to determine the comparative incidence of cross-reactivity associated with carbapenem antibiotic treatment among patients with versus those without penicillin allergy. We sought to determine whether the incidence of cross-reactivity is different between imipenem-cilastatin and meropenem. A total of 211 patients were treated with a carbapenem antibiotic. Included were 100 patients with and 111 patients without a documented or reported penicillin allergy. Within each group, subgroups of penicillin-allergic and penicillin-nonallergic patients were balanced equally between imipenem-cilastatin and meropenem. The incidence of patients with a reported or documented penicillin allergy experiencing an allergic-type reaction to a carbapenem was 11%, which is 5.2 times greater than the risk in patients who were reportedly not allergic to penicillin (P=.024). No difference in the occurrence of allergic-type reactions was observed between the 2 carbapenems.

Adolescent↗
PubMed2004

Drug interactions between antibiotics and select maintenance medications: seeing more clearly through the narrow therapeutic window of opportunity.

OBJECTIVE: Infections often occur while treating patients with long-term medications for chronic illnesses. Treating these infections with systemic antibiotics often leads to pharmacokinetic and pharmacodynamic interactions between the antimicrobials and one or more of the maintenance medications. Previously optimized long-term regimens may become either subtherapeutic or super-therapeutic, with deleterious consequences. This article discusses some of the most significant and commonly encountered antibiotic drug interactions that may occur with medications with "narrow therapeutic windows" including warfarin, phenytoin, carbamazepine, theophylline, and the two calcineurin inhibitors. Given the logistics of many consultant pharmacists' practices, it may not always be possible for them to react prospectively when these combinations are prescribed at their facilities. Therefore, there are several things the pharmacist can do: provide regular and comprehensive inservice raining on this topic, be available as needed to answer patient-specific questions, and provide readily available charts and other educational materials that help identify and characterize these important interactions. DATA SOURCES: A Medline search of the English literature was performed in October/November 2003, going back to 1980 for the commonly used antibiotics and drug interactions stated in this text. In some cases, cross referencing of articles reviewed also led to older publications. Textbooks dealing with drug interactions also were used as initial sources. However, whenever possible, any data quoted within the text were verified from the original research paper. STUDY SELECTION: Pharmacokinetic studies, case reports, and general review articles published in the English medical literature were all selected for review. In cases where review articles were cited that summarize groups of data from previous original research papers, the authors made the best possible effort to verify the accuracy by referring to the original research papers. DATA SYNTHESIS: Because of the breadth of the topic in terms of all the antibiotics discussed, the interacting medications that pertained to each antibiotic, and the lack of homogeneity among the various types of papers (most of which were case reports), most analyses include broad-based summaries based on the aggregate findings of the authors. CONCLUSION: The addition of antibiotics to a stabilized medical regimen can result in either potentiation or antagonism of the clinical effects of narrow-therapeutic-window medications such as warfarin, phenytoin, theophylline, calcineurin inhibitors, carbamazepine, and numerous other agents. As usual in the clinical arena, awareness is the first step in appropriate management of these encounters.

Journal Article↗
PubMed2003

The effect of an antimicrobial restriction program on Pseudomonas aeruginosa resistance to beta-lactams in a large teaching hospital.

STUDY OBJECTIVES: To compare the use of beta-lactams and subsequent Pseudomonas aeruginosa sensitivity patterns before and after implementation of a clinical pharmacist-facilitated antimicrobial restriction program in August 1997. DESIGN: Retrospective consecutive data collection. SETTING: Large university-affiliated medical center. INTERVENTION: The study results are the accumulation of the daily intervention activities of the antimicrobial restriction program. Data on antimicrobial grams purchased/1,000 patient-days and susceptibility patterns were collected and analyzed retrospectively. MEASURES AND MAIN RESULTS: Annual grams of ceftazidime, piperacillin, piperacillin-tazobactam, and other antipseudomonal beta-lactams purchased/1,000 patient-days were compared during the 2 full calendar years before the antimicrobial restriction program (1995-1996) with the 4 full calendar years after the program was implemented (1998-2001). Pseudomonas aeruginosa resistance trends for the antipseudomonal beta-lactams, ciprofloxacin, and tobramycin also were compared for the 2 years before the program (1995-1996) with the last 2 years of the program (2000-2001). A 44% reduction in ceftazidime use was documented; ostensibly, minimal changes occurred in the overall use of piperacillin and piperacillin-tazobactam. During the same time period, ceftazidime resistance fell from 24% to 11.8% (p<0.001), whereas piperacillin resistance fell from 32.5% to 18.5% (p<0.001). Imipenem resistance declined from 20.5% to 12.3% (p<0.001) with an 18% reduction in use. Aztreonam resistance declined from 29.5% to 16.5% (p<0.001) despite a 57% increase in use. No changes in resistance to either ciprofloxacin or tobramycin were found. CONCLUSION: Through an antimicrobial restriction program, a dramatic reduction in ceftazidime use was achieved with judicious use of other antipseudomonal antimicrobials, which resulted in reduced resistance of P aeruginosa to other beta-lactams.

Anti-Bacterial Agents↗