Biomedical subjects

Raymond M Klein

Publications and source records attributed to Raymond M Klein.

At least 19 recordsLinked to original sources

PubMed2006

The ABCs of computerized naming: equivalency, reliability, and predictive validity of a computerized rapid automatized naming (RAN) task.

Population-based studies indicate dual routes to disabled reading in adolescence and adulthood: slowed acquisition of single word reading and ADHD (particularly inattention) in early childhood. Impairments in rapid serial naming may be a factor common to both problems. The gold-standard measure of this ability, the Rapid Automatized Naming Task (RAN; [Denckla MB, Rudel R. Rapid automatized naming of pictured objects, colors, letters and numbers by normal children. Cortex 1974;10:186-202]), has traditionally been administered in a paper-pencil format. Recently however, researchers [Neuhaus GF, Carlson CD, Jeng WM, Post Y, Swank PR. The reliability and validity of rapid automatized scoring software ratings for the determination of pause and articulation component durations. Educ Psychol Meas 2001;61:490-504] have begun to use computerized versions of the RAN. Here a slightly modified computerized version of the RAN was created and the equivalency between the computerized RAN and the conventional version was investigated using a university student sample. Naming times on the conventional and computerized RAN were highly correlated, overall, and for each of the four RAN stimulus types (letters, digit, colors, objects). Conventional and computerized RAN times predicted reading rate and reading comprehension scores equally well and both showed very high test-retest reliability. With our university student sample, findings indicate equivalency between the two testing mediums in all areas examined.

Adult↗

PubMed2006

Inhibition of return: sensitivity and criterion as a function of response time.

Inhibition of return (IOR) refers to a mechanism that results in a performance disadvantage typically observed when targets are presented at a location once occupied by a cue. Although the time course of the phenomenon--from the cue to the target--has been well studied, the time course of the effect--from target to response--is unknown. In 2 experiments, the effect of IOR upon sensitivity and response criterion under different levels of speed stress was examined. In go/no-go and choice reaction time tasks, IOR had at least 2 distinct effects on information processing. Early in target processing, before sufficient target information has accrued, there is a bias against responding to cued targets. Later, as target information is allowed to accrue, IOR reduces sensitivity to the target's nonspatial feature. Three accounts relating to the early bias effect of IOR and the late effect of IOR on sensitivity are offered.

Attention↗

PubMed2006

The effects of memory load on the time course of inhibition of return.

Inhibition of return (IOR) refers to a processing disadvantage at a recently attended location. It is generally agreed that when elicited in a cue-target task, IOR will not be apparent until attention is disengaged from the originally cued location and returned to a neutral state. Here we test the hypothesis that when such disengagement is dependent on endogenous control, a secondary task that taxes working memory capacity should delay the appearance of IOR. Participants were given a six-item verbal working memory load prior to the peripheral cue in a cue-target detection task. Consistent with the hypothesis, the appearance of IOR was delayed on trials for which participants had to hold information in working memory. Converging evidence was derived from a second experiment in which the time course of IOR's appearance, when we added a central cue to exogenously remove attention from the peripheral cue, was unaffected by the memory load.

Attention↗

PubMed2005

Age changes in the missing-letter effect revisited.

When participants search for a target letter while reading, they make more omissions if the target letter is embedded in frequent function words than in less frequent content words. Reflecting developmental changes in component language and literacy skills, the size of this effect increases with age. With adults, the missing-letter effect is due to both word function and word frequency. With children, it is unclear whether the growing size of the missing-letter effect across development is due to a larger effect of word function, word frequency, or both because previous studies with children seeking to isolate the influence of word frequency and word function suffer from important methodological limitations. With these methodological limitations eliminated (Experiments 1 and 2), performance in a letter detection task was assessed for children in Grades 1, 2, 3, 4, and 7 as well as for undergraduate students. The results revealed that the influence of word function increases with age, whereas the effect of frequency is fairly stable across ages. Furthermore, normative predictability data collected in Experiment 3 revealed that third graders and undergraduate students were equally good at predicting function slots in a sentence.

Adult↗

PubMed2005

Contingent gambling-drinking patterns and problem drinking severity moderate implicit gambling-alcohol associations in problem gamblers.

Although problem gambling and problem drinking often co-occur, the processes underlying this association are not well understood. This study investigated the effects of contingent gambling-drinking patterns and problem drinking severity on implicit gambling-alcohol associations. Participants were 144 (34 female) problem gamblers. The South Oaks Gambling Screen (SOGS) measured severity of problem gambling. The Brief Michigan Alcohol Screening Test (BMAST) measured severity of problem drinking. The Implicit Association Test (Greenwald, McGhee, & Schwartz, 1998, Journal of Personality and Social Psychology, 74, 1464-1480) measured gambling-alcohol associations. Participants who reported drinking when they won displayed faster response time (i.e., priming) on trials where alcohol words were paired with gambling win (e.g., jackpot) vs. gambling loss (e.g., forfeit) words. The tendency to drink in response to losses did not influence the priming effect of win cues or moderate the effects of Win-Drinking Pattern on priming. Severity of problem drinking on the BMAST also correlated positively the priming effects of win cues. These findings indicate that a tendency to drink in response to gambling wins and more severe alcohol problems each coincide with stronger associations between gambling win and alcohol concepts in memory. Such associations can promote drinking and its attendant effects (e.g., poor decision-making) in problem gamblers, and thus, may contribute to co-morbid gambling and alcohol use disorders.

Adult↗

PubMed2005

Heart rate increase to alcohol administration and video lottery terminal (VLT) play among regular VLT players.

The authors examined heart rate responses to video lottery terminal (VLT) play and alcohol intake. Forty-four VLT players were randomized to an alcohol (mean blood alcohol concentration=0.06%) or a control beverage condition. Heart rate was recorded at pre- and postdrinking baseline and during VLT play. Alcohol participants displayed elevated heart rates relative to controls at postdrinking and VLT play. Controls displayed elevated heart rates during VLT play relative to both pre- and postdrinking baselines, whereas alcohol participants displayed elevations at post- relative to predrinking and at VLT play relative to postdrinking. Heart rate increases from predrinking to VLT play were greater among alcohol participants relative to controls. Results provide novel information that the combination of VLT play and alcohol further intensifies heart rate increase relative to either alone. Implications for pathological gambling and alcohol use disorder comorbidity are discussed.

Adult↗

PubMed2005

Looking for inhibition of return in pigeons.

We conducted four experiments in order to investigate whether pigeons' responses to a recently attended (i.e., recently pecked) location are inhibited. In Experiments 1 and 2, stimulus displays were similar to those used in studies of inhibition of return (IOR) with humans; responses to cued targets tended to be facilitated rather than inhibited. In Experiments 3 and 4, birds were presented with stimulus displays that mimicked clusters of small grains and were relatively localized, which should have been more appropriate for detecting IOR in pigeons. The results from these experiments again provided evidence for facilitation of responding to cued targets, rather than for IOR.

Animals↗

PubMed2005

Does attention cause illusory line motion?

Illusory line motion (ILM) has been shown to occur when a line is presented with one end next to a previously stimulated location. The line appears to be drawn away from the site of stimulation. It has been suggested that this is because of the allocation of attention to the stimulated site. Using an endogenous attentional manipulation (a central arrow cue) with no differences in the display between the two ends of the line at the time of line presentation or immediately prior, no ILM was detected, though there was a small effect in the opposite direction. Those who have found endogenously induced ILM have used an endogenous cue based on a property of a location marker that indicated the cued location. Changing the method of cuing to one based on a property of a peripheral marker instead of a central arrow produced a small but significant report of ILM. The small magnitude of the effect, participant self-reports, and the absence of the effect in the purely endogenous condition, suggest that this was merely a bias. ILM is not generated by endogenous attention shifts.

Attention↗

PubMed2005

Vector averaging of inhibition of return.

Observers detected targets presented 400 msec after a display containing one cue or two to four cues displayed simultaneously in randomly selected locations on a virtual circle around fixation. The cue arrangement was completely uninformative about the upcoming target's location, and eye position was monitored to ensure that the participants maintained fixation between the cue and their manual detection response. Reflecting inhibition of return (IOR), there was a gradient of performance following single cues, with reaction time decreasing monotonically as the target's angular distance from the cued direction increased. An equivalent gradient of IOR was found following multiple cues whose center of gravity fell outside the parafoveal region and, thus, whose net vector would activate an orienting response. Moreover, on these trials, whether or not the targeted location had been stimulated by a cue had little effect on this gradient. Finally, when the array of cues was balanced so that its center of gravity was at fixation, there was no IOR. These findings, which suggest that IOR is an aftermath of orienting elicited by the cue, are compatible with population coding of the entire cue (as a grouped array for multiple cues) as the generator of IOR.

Cues↗

PubMed2004

Covert orienting within peripersonal and extrapersonal space: young adults.

Covert orienting within peripersonal (near) and extrapersonal (far) space was investigated in a large sample of young adults. The participants made speeded responses to targets in a simple, go/no-go detection task. Stimuli, equated for eccentricity and size, were presented at two distinct distances from the observer, representing peripersonal space and extrapersonal space. Within each distance condition cues and targets were presented at the four corners of an imaginary square allowing assessment of the influence of attention upon targets presented in the upper and lower as well as left and right visual fields. In the neutral condition lower field targets had a small advantage over upper field targets. This effect was also observed under cued conditions. When presented in peripersonal space, near targets benefited more from valid cuing than did targets in the other conditions. This pattern is discussed in terms of Previc's [Behav. Brain Sci. 13 (1990) 519] model of visual field specialization.

Adolescent↗

PubMed2004

One missing-letter effect: two methods of assessment.

When participants search for a target letter while reading, they make more omissions if the target letter is embedded in frequent function words than in less frequent content words. This effect is usually observed with a paper and pencil procedure. It has been shown that a similar pattern is observed using a rapid serial visual presentation procedure in which words appear one at a time on a computer screen. It has been questioned, however, whether the two methods tap the same cognitive processes. Item-based correlations between the paper and pencil and the rapid serial visual presentation procedure were high and not significantly different from reliability estimates of either procedure. It is concluded that both procedures highlight the same cognitive processes that are responsible for the missing-letter effect.

Female↗

PubMed2004

Stimulus-response probability and inhibition of return.

Inhibition of return (IOR) refers to slowed responding to targets at a location previously occupied by an irrelevant cue. Here we explore the interaction between stimulus-response (S-R) probability and IOR effects using go/no-go (Experiment 1) and two-choice discrimination tasks (Experiment 2). In both experiments, the IOR effect was larger for the likely S-R ensemble than for the unlikely one. In the first experiment, there were more false alarms for uncued targets than for cued targets, and this difference was larger for the unlikely S-R ensemble than for the likely one. In the second experiment, the same pattern was observed for incorrect keypress responses. As with voluntary orienting in response to predictive central cues, the results suggest that IOR affects late stages of processing by altering the criteria to respond to targets presented at the cued (previously attended) location.

Conditioning, Classical↗

PubMed2003

Inhibition of return biases orienting during the search of complex scenes.

In Klein and MacInnes, observers searched a complex scene for a camouflaged target. Reflecting Inhibition of Return (IOR) observers were slower to detect and saccade to uncamouflaged probes that interrupted active search when these were placed in the vicinity of a recent fixation. To explore the generality of this finding of IOR during search, we changed the mental state of the observer at the time of the probes by instructing observers to inspect the scene until they found something interesting and stop there. After this voluntary cessation of search, we presented an uncamouflaged probe that observers were required to foveate. Extending our previous demonstration, we observed a relative increase in the time required to locate these probes when they were in the general region of a previous fixation so long as the scene was maintained. When the scene was removed, probe reaction time was unaffected by distance from the last fixation. The pattern of results supports the proposal that IOR biases overt orienting during search.

Adult↗

PubMed2003

Inhibition of return in children and adolescents.

Inhibition of return (IOR), slowed responding to targets at a cued location after attention is removed from this location, has been shown to occur both in adults and in infants. To explore suggestion that the timecourse of IOR depends on factors that might affect the efficiency with which attention is removed from the cued location, we compared the performance of young children (5-10-year-olds, N=49, M=8 years, 4 months) to older children and adolescents (11-17-year-olds, N=61, M=14 years) in single and double cue procedures. Cue-target interval was varied to measure the timecourse of IOR in this within-subjects localization task. Whereas no IOR was found in the young group unless a double cue procedure was used, in the older group, we found IOR at all intervals with the double cue procedure and the typical crossover pattern, with early facilitation followed by inhibition in the single cue procedure.

Adolescent↗

PubMed2003

Direct assessments of the processing time hypothesis for the missing-letter effect.

When participants search for a target letter while reading, they make more omissions if the target letter is embedded in frequently used words or in the most frequent meaning of a polysemic word. According to the processing time hypothesis, this occurs because familiar words and meanings are identified faster, leaving less time for letter identification. Contrary to the predictions of the processing time hypothesis, with a rapid serial visual presentation procedure, participants were slower at detecting target letters for more frequent words or the most frequent meaning of a word (Experiments 1 and 2) or at detecting the word itself instead of a target letter (Experiment 3). In Experiments 4 and 5, participants self-initiated the presentation of each word, and the same pattern of results was observed as in Experiments 1 and 3. Positive correlations were also found between omission rate and response latencies.

Adult↗

PubMed2003

Orienting of attention without awareness is affected by measurement-induced attentional control settings.

McCormick (1997) concluded that peripheral cues presented below a threshold of awareness could nevertheless attract attention because they facilitated target processing near the cue shortly after its presentation. Yet, whereas an exogenous shift of attention typically exhibits a biphasic pattern (initial facilitation followed by inhibition of return [IOR]), at late cue-target onset asynchronies, IOR was not observed by McCormick. In our study, targets requiring a detection response were preceded by masked and nonmasked, uninformative cues presented under two conditions: one in which the cue was ignored (no report) and one in which the cue was detected and localized following the response to the target (cue report). When participants were required to make cue judgments at the end of each trial, we replicated McCormick's pattern, finding facilitation (but not IOR) following both masked and nonmasked cues. When there was no requirement to judge the presence or location of the cues, IOR was present with and without masks, whereas facilitation was observed only when the cues were not masked. That the assessment of cue awareness increases attentional facilitation and prevents (or delays) the onset of IOR is attributed to attentional control settings put in place to perform the cue-awareness assessments in the cue-report condition.

Attention↗

PubMed2002

Contribution of the primate superior colliculus to inhibition of return.

The phenomenon of inhibition of return (IOR) has generated considerable interest in cognitive neuroscience because of its putative functional role in visual search, that of placing inhibitory tags on objects that have been recently inspected so as to direct further search to novel items. Many behavioral parameters of this phenomenon have been clearly delineated, and based on indirect but converging evidence, the widely held consensus is that the midbrain superior colliculus (SC) is involved in the generation of IOR. We had previously trained monkeys on a saccadic IOR task and showed that they displayed IOR in a manner similar to that observed in humans. Here we recorded the activity of single neurons in the superficial and intermediate layers of the SC while the monkeys performed this IOR task. We found that when the target was presented at a previously cued location, the stimulus-related response was attenuated and the magnitude of this response was correlated with subsequent saccadic reaction times. Surprisingly, this observed attenuation of activity during IOR was not caused by active inhibition of these neurons because (a) they were, in fact, more active following the presentation of the cue in their response field, and (b) when we repeated the same experiment while using the saccadic response time induced by electrical micro-stimulation of the SC to judge the level of excitability of the SC circuitry during the IOR task, we found faster saccades were elicited from the cued location. Our findings demonstrate that the primate SC participates in the expression of IOR; however, the SC is not the site of the inhibition. Instead, the reduced activity in the SC reflects a signal reduction that has taken place upstream.

Action Potentials↗

PubMed2002

Temporal dynamics of reflexive attention shifts: a dual-stream rapid serial visual presentation exploration.

We combined a prototypical exogenous cuing procedure with rapid serial visual presentation (RSVP) to provide a precise characterization of the temporal dynamics of reflexive attention shifts. The novel paradigm thus created has several useful properties, most notably that the physical presentation of the target is neither an onset nor a unique event and that temporal precision is provided without the requirement for a speeded response. A biphasic pattern was observed, with early benefits followed by later costs (inhibition of return) at the cued location relative to the uncued location. The finding of inhibition of return in this paradigm disproves the assertion that inhibition of return is merely a reluctance to respond in the target's direction. It may be partly that, but encoding mechanisms linked to attention must also be involved.

Adult↗