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Biomedical subjects

Rebecca L Slayton

Publications and source records attributed to Rebecca L Slayton.

14 recordsLinked to original sources
PubMed2006

Biotech and biomaterials research to reduce the caries epidemic.

The goal of this workshop is to develop a consensus within the biomaterials/bioengineering community for a research agenda focused on creating technologies that will address the current dental caries pandemic. The workshop will bring together expertise from academia, industry, and the NIH institutes in the areas of oral biofilm microbiology and innovative biomaterials. The rationale for the workshop is that science and technology have not produced sufficient practical tools for public health practitioners and the private delivery system to address the pandemic in dental caries that exists for children and adults from families with low incomes and for numerous ethnic minority and racial groups. Moreover, it is unclear whether the barriers are remediable bioengineering and technical problems or fundamental science questions. Nevertheless, the obligation to address the gap between scientific research and practical application is especially relevant today. The U.S. and state governments bear the majority of the cost of trying to control this pandemic through Medicaid, the Public Health Service, Indian Health Service and other similar programs. These costs continue to escalate as continued applications of existing technology are unlikely to markedly reduce disparities. The mainstays of caries prevention, topical and systemic fluorides and pit and fissure sealants, are technologies developed in the 1950s and 1960s.

Journal Article↗
PubMed2006

A new oral health elective for medical students at the University of Washington.

BACKGROUND: Oral health is an important but inadequately addressed area in medical school curricula. Primary care practitioners are in an ideal position to help prevent oral disease but lack the knowledge to do so. PURPOSES: We developed an oral health elective that targeted 1st- and 2nd-year medical students as part of a previously described oral health initiative and oral health curriculum. METHODS: To promote interprofessional collaboration, we utilized medical-dental faculty teams for lectures and hands-on peer instruction by dental students for clinical skills. RESULTS: Evaluations revealed positive shifts in attitudes toward oral health and significant gains in oral health knowledge and self-confidence. Students rated the course highly and advocated for further integration of oral health into required medical curricula. CONCLUSIONS: We describe the elective including curriculum development, course evaluation results, and steps for implementing a successful oral health elective into medical education. We highlight interprofessional collaboration and constituency building among medical and dental faculty and administrators.

Curriculum↗
PubMed2003

Genetic association studies of cleft lip and/or palate with hypodontia outside the cleft region.

OBJECTIVE: The purpose of this study was to determine whether the candidate genes previously studied in subjects with cleft lip, cleft palate, or both are associated with hypodontia outside the region of the cleft. SUBJECTS: One hundred twenty subjects from the Iowa Craniofacial Anomalies Research Center were selected based on the availability of both dental records and genotype information. METHOD: The type of orofacial clefting and type and location of dental anomalies (missing teeth, supernumerary teeth, or peg laterals) were assessed by dental chart review and radiographic examination. Genotype analysis of candidate genes was performed using polymerase chain reaction/single-strand conformation polymorphism analysis. RESULTS: The prevalence of hypodontia in this sample was 47.5%, with 30.0% of subjects having missing teeth outside the cleft. There was a positive association between subjects with cleft lip or cleft lip and palate who had hypodontia outside the cleft region (compared with noncleft controls) and both muscle segment homeo box homolog 1 (MSX1) (p =.029) and transforming growth factor beta 3 (TGFB3) (p =.024). It was not possible in this analysis to determine whether this association was specifically associated with orofacial clefting combined with hypodontia or whether it was due primarily to the clefting phenotype. CONCLUSIONS: In this sample, there was a significantly greater incidence of hypodontia outside the cleft region in subjects with cleft lip and palate, compared with cleft lip only or cleft palate only. Cleft lip and/or palate with hypodontia outside the cleft region was positively associated with both TGFB3 and MSX1, compared with noncleft controls.

Anodontia↗
PubMedDate not supplied

Frequency of reported dental visits and professional fluoride applications in a cohort of children followed from birth to age 3 years.

PURPOSE: The purpose of this study is to report the prevalence of having a dental visit and/or a topical fluoride treatment at the dental visit from birth to age 36 months from an observational, longitudinal study of a cohort of children followed since birth. METHODS: Multiple questionnaires were sent to the families of children enrolled in a study of fluoride ingestion to ask parents if their child had had a dental (or dental hygiene) appointment and/or a fluoride treatment during the time interval since the previous mailed survey. Data were analyzed to determine the percentages of children who had at least one dental visit or at least one fluoride treatment by one, two or three years of age. RESULTS: Three hundred and forty parents completed all eleven questionnaires during the 36-month study period. Of these, 2% reported having taken their child for a dental visit by one year of age, 11% by two years of age and 31% by three years of age. Of those with a visit by three years of age, 19% received at least one fluoride treatment. CONCLUSIONS: Despite recommendations for early dental visits, only 31% of the children in this cohort had been seen by a dentist by the time they reached their third birthday and 19% of these had received a professional fluoride treatment.

Child, Preschool↗
PubMedDate not supplied

Tooth eruption symptoms: a survey of parents and health professionals.

UNLABELLED: It is commonly believed that teething in infants can cause a variety of signs and symptoms. Previous studies have suggested an association between teething and fever, irritability, drooling, rashes, vomiting, diarrhea, night crying, and convulsions. PURPOSE: The objective of this study was to evaluate differences in the beliefs of pediatricians, pediatric dentists and parents regarding symptoms caused by teething in infants. METHODS: A survey consisting of demographic information and questions concerning commonly reported symptoms associated with teething was administered to 100 randomly selected Iowa pediatricians, all practicing pediatric dentists in Iowa (n = 33) and a convenience sample of 120 parents from the greater Iowa City area. Responses were analyzed using the Chi-square test. RESULTS: Response rates for each group were: pediatricians 45%; pediatric dentists 76%; and parents 50%. The majority of individuals in each group believed that teething in infants can cause swollen gums, drooling, irritability, inflamed gums, restlessness, sleeplessness, and fever. There were significant differences in the percent of agreement relating to drooling (p = 0.001), inflamed gums (p = 0.001), and sleeplessness (p = 0.027). A greater percentage of pediatric dentists and parents agreed that these symptoms were caused by teething than did pediatricians. The largest difference between groups was related to the association between teething and diarrhea. The majority of parents (56.7%) and pediatric dentists (52.0%) believed that diarrhea is associated with teething compared to just 9.1% of pediatricians. CONCLUSIONS: These results support the hypothesis that differences regarding beliefs about teething symptoms exist between parents, pediatricians, and pediatric dentists. There is more agreement between parents and pediatric dentists than between either of these groups and pediatricians.

Attitude of Health Personnel↗
PubMedDate not supplied

Interdental spacing and caries in the primary dentition.

PURPOSE: This study assessed the relationship between interdental spacing patterns and caries experience in the primary dentition. METHODS: Caries examinations were conducted amoung 356 children 4 to 6 years of age. At the time of the examinations, alginate impressions were obtained and poured in yellow stone. From the stone casts, each interdental area was categorized as: (1) space > 1 mm, (2) space < 1 mm, (3) no space, teeth in contact, or (4) no space, teeth overlapped. These categories were collapsed into presence or absence of space for each interdental site, and counted for each individual. Analyses assessed the relationships between interdental spacing and caries experience with separate analyses for anterior spacing, posterior spacing and total spacing. RESULTS: Children with more total interdental spaces had less decay experience and less untreated decay than children with fewer interdental spaces, and children with more molar spacing had less molar decay experience; however, these relationships were weak. Correlation analyses demonstrated significant relationships between number of decayed surfaces and total number of interdental spaces (r=-0.11, P=.04) and number of molar sites with interdental spaces (r=-0.13, P=.02). Multivariate analyses revealed the total number of interproximal spaces to be weakly associated with interproximal caries experience, but that fluoride exposure was a much stronger predictor. CONCLUSIONS: Absence of interdental spaces is weakly associated with greater decay experience in the primary dentition.

Chi-Square Distribution↗
PubMedDate not supplied

The effect of chronic methylphenidate administration on tooth maturation in a sample of Caucasian children.

PURPOSE: Over the past 3 decades, methylphenidate hydrochloride (MH; brand names are Concerta, Metadate, Ritalin) has been increasingly prescribed for children and adolescents diagnosed with attention deficit hyperactivity disorder (ADHD). Previous studies have demonstrated growth suppression with chronic MH administration in children and adolescents and an association of delayed dental maturation with delayed growth. It was hypothesized that, perhaps with MH use, there is a concurrent retardation in dental development. Although there has been an abundance of research done on its effect on skeletal development, no one has examined MH's possible effects on the oral cavity-particularly dental development. The purpose of this study was to evaluate dental maturation in children who had taken MH chronically. METHODS: Forty-two Caucasian children between the ages of 7 and 15.9 years who had taken MH for a minimum of 2 years were enrolled. Their dental development was compared to that of a contemporary age- and gender-matched control sample using the Demirjian method to assess dental age. RESULTS: It was found that this study's population of children, who ingested an average dose of 30 mg of MH daily for a mean duration of 54 months, showed no delay in dental maturation. CONCLUSIONS: It is concluded that, for these amounts of MH exposure, there is no effect on dental maturation.

Adolescent↗
PubMedDate not supplied

Effects of nonnutritive sucking habits on occlusal characteristics in the mixed dentition.

PURPOSE: Little is known about the extent to which nonnutritive sucking habits contribute to malocclusion in the mixed dentition. The purpose of this study was to report on the relationship between certain occlusal traits in the mixed dentition and longitudinal sucking behaviors. METHODS: Dental examinations were conducted on 630 children in the mixed dentition who participated in a large, ongoing longitudinal study. Five hundred eighty consented to impressions, and 524 adequate study models were obtained. Of these, 444 also had adequate longitudinal nonnutritive sucking data obtained via mailed questionnaires to parents at 3- to 6-month intervals from birth to 8 years. Sucking behaviors were grouped by predominant type and duration. Study models were hand articulated using wax bites to evaluate the occlusion for the presence of open bite, crossbite, molar relationship, and excessive overjet. Bivariate statistical analyses related presence of these malocclusions to sucking duration and type. RESULTS: Fifty-five percent of the children had malocclusions (anterior open bite, posterior crossbite, bilateral Class II molar relationship, or overjet >4 mm). Class II molar relationship was most common (30%). Overall, anterior open bite and posterior crossbite was associated with habits of 36 months or more. Sustained pacifier habits, including those of 24 to 47 months, were associated with anterior open bite and Class II molar relationships, while digit habits were associated with anterior open bite when sustained for 60 months or longer. CONCLUSIONS: Malocclusions are quite prevalent in the mixed dentition, and anterior open bite and posterior crossbite may be preventable by modifying nonnutritive sucking behaviors.

Chi-Square Distribution↗