Bilateral recurrent laryngeal nerve palsy resulting from treatment with vincristine.
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Antineoplastic Agents, Phytogenic↗
Biomedical subjects
Remy H Blanchaert
Publications and source records attributed to Remy H Blanchaert.
Mandibulotomy fixation: a laboratory analysis.
PURPOSE: Mandibulotomy is an access osteotomy technique associated with significant complications. Critical evaluation of available fixation systems is required to aid in the selection of the most stable fixation method. This study was designed to provide data on the stability of traditionally used plating configurations and a low-profile 2.0-mm locking plate (mandibular locking plate, Synthes MLP; Synthes Maxillofacial, Paoli, PA). MATERIALS AND METHODS: An in vitro red oak model was used to evaluate the stability provided by the study fixation devices. Five groups were studied as follows: group 1, two 4-hole 2.0-mm nonlocking miniplates; group 2, two 4-hole 2.0-mm mandibular locking plates; group 3, one 6-hole 2.0-mm mandibular locking plate; group 4, one 6-hole 2.4-mm nonlocking rigid plate; and group 5, control (uncut red oak blocks). Each specimen was tested with vertical loads applied over the osteotomy site. The force-versus-displacement behavior was recorded for each specimen and analyzed statistically. RESULTS: Plate type and configuration affected the resistance to vertical peak load (kilogram/force [kgf]) and the fixation stiffness (kgf/mm). The greatest peak load (58.92 kgf) and stiffness (7.07 kgf/mm) was found with group 2 specimens. The differences in system stiffness were statistically significant (P <.05), as were the peak loads for groups 1, 2, and 3. The control group (nonosteotomized red oak) had markedly higher values of peak load and stiffness (484 kg and 83 kg/mm, respectively). Group 2 specimens exhibited increased resistance to flexion. CONCLUSIONS: Two 2.0-mm locking plates provided the greatest resistance to vertical load.
Biomechanical Phenomena↗
Intraosseous mandibular lesion.
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Burkitt Lymphoma↗
Oral leiomyosarcoma: review of the literature and report of two cases with assessment of the prognostic and diagnostic significance of immunohistochemical and molecular markers.
Leiomyosarcoma of the oral cavity is a very rare tumor that is associated with aggressive clinical behavior and low survival. In this paper, we report two new cases of leiomyosarcoma affecting the mandibular gingiva and mandible of a 35-year-old male and the mandible of a 51-year-old female. Given the difficulty in the histopathologic discrimination between benign and malignant smooth muscle tumors and the absence of reliable histologic parameters for prognostication of leiomyosarcomas, we evaluated the diagnostic and prognostic value of various immunohistochemical and molecular markers. By means of immunohistochemistry and quantitative real-time PCR analysis, we detected protein expression of PCNA, bcl-2, CDK4, p53 and MDM2 in both our cases and MDM2 amplification in our second case. The literature, pertinent to oral leiomyosarcoma and to molecular analysis of smooth muscle tumors, is reviewed.
Adult↗
Oral and oral pharyngeal cancer: an update on incidence and epidemiology, identification, advances in treatment, and outcomes.
Dental health care providers offer a primary means by which improvements in outcome in oral and oral pharyngeal cancer can be realized. Early detection of mucosal abnormalities (e.g., leukoplakia, erythroplakia), which may represent the earliest identifiable premalignant change, requires only thorough oral-examination skills. Patient education and efforts to decrease the use of tobacco products are a critical means of decreasing incidence. Changes in cancer incidence related to tobacco cessation will take many years to affect statistical rates of oral and oral pharyngeal cancer.
Carcinoma, Squamous Cell↗