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Biomedical subjects

Renaud Deplus

Publications and source records attributed to Renaud Deplus.

12 recordsLinked to original sources
PubMed2004

[Acute cytomegalovirus (CMV) recto-colitis mimicking rectal carcinoma without apparent cause of immunodeficiency].

Cytomegalovirus (CMV) infection of the gastrointestinal tract occurs mainly in immunosuppressed patients. We report here the case of a 76-Year-old woman, without obvious cause of immunosuppression, who developed severe proctitis. The clinical course was favourable with ganciclovir therapy. In the absence of controlled data in the field of CMV intestinal infections in immunocompetents, we discuss the potential benefit of an antiviral therapy in those patients who do not recover rapidly and spontaneously.

Acute Disease↗
PubMed2004

[Tropical sprue: two cases in the Paris area].

Tropical sprue (TS) is a postinfective tropical malabsorption that occurs in tropical countries. TS is associated with a persisting colonization of the small-intestine lumen by enterotoxinogenic bacteria that cause subsequent enterocyte damage affecting all or part of the small-intestine. We report two cases of TS that occurred in inhabitants of Paris area returned from endemic areas. The first observation concerned a 76-year old woman admitted for anorexia, loss of 20 kg and anemia. The second observation concerned a 53-year old man referred for chronic diarrhea and loss of 40 kg within 4 years. In both cases, duodenal lesions consisted of subtotal and total villous atrophy with prominent infiltration of the damaged surface epithelium with lymphocytes and infiltrate of lymphocytes and plasma cells of the lamina propria. The two patients recovered under antibiotics, confirming the diagnosis of TS.

Aged↗
PubMed2002

[Regression of hepatocellular carcinoma under Tamoxifen: report of one case and review of the literature].

Hepatocellular carcinoma is a malignant tumor with a poor prognosis, particularly when it is unresectable. The results of tamoxifen treatment in hepatocellular carcinoma have been disappointing and randomized studies have shown conflicting results. We report the case of a 72-yr-old-man with histologically confirmed hepatocellular carcinoma on a normal liver, that regressed with tamoxifen treatment. Regression was confirmed by normalization of serum alpha-fetoprotein levels and a significant decrease in radiological lesions by 66%. The patient was alive in excellent clinical condition more than 30 months after the initial diagnosis.

Aged↗
PubMedDate not supplied

[Sarcomatoid carcinoma of the colon: report of a case and review of the literature].

Sarcomatoid carcinomas or carcinosarcoma are rare tumors composed of mixed carcinoma cells and mesenchymal cells. Thirteen cases with colorectal involvement have been published to date. We report a case of sarcomatoid carcinoma of the colon in a 67-Year-old woman hospitalized with a history of anemia and bloody stools. The patient underwent a left hemicolectomy. Immunohistochemistry revealed two cell components (undifferentiated carcinomatous and sarcomatous components). The patient died of her tumor 2 Months after the operation. Our review of the literature stresses the poor prognosis associated with colonic sarcomatoid carcinoma.

Aged↗
PubMedDate not supplied

[Single filiform polyp revealed by severe haemorrhage in a patient with normal colon. Report of a case and review of the literature].

Filiform polyposis or giant inflammatory polyp is an uncommon benign lesion that has principally been reported in patients with evidence of inflammatory bowel disease, Crohn's disease or ulcerative colitis. It appears to be a sequella of diffuse mucosal inflammation. More rarely, PF found in association with colonic non specific inflammation. PF has rarely been reported in patients without previous colonic disease. We report the case of a 60-year-old woman without history of colonic disease who presented a PF revealed by hematochesia.

Colonic Polyps↗
PubMedDate not supplied

[Isolated ileal villous atrophy: a rare cause of chronic diarrhea. Report of a case and review of the literature].

Villous atrophy of the terminal ileum is usually secondary to celiac disease or other diseases. Very few cases of primary ileal villous atrophy have been reported in the literature. We report here the case of a 37-year-old man with chronic diarrhea since childhood without features of malabsorption. The macroscopic and microscopic appearance of the duodenal, ileal and colonic mucosae at endoscopy and contrast radiography of the small bowel was normal. Ileal lesions consisted of total villous atrophy. Search for antinuclear antibodies, anti-endomysium and anti-gliadin IgA and IgG and HIV serology were negative. Serum immunoglobulin level was normal. Diarrhea resolved under treatment with colestyramine.

Adult↗