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Biomedical subjects

Renuka Srinivasan

Publications and source records attributed to Renuka Srinivasan.

6 recordsLinked to original sources
PubMed2007

Case reports of three patients showing optic nerve head melanocytoma and systemic hypertension.

PURPOSE: To report the association of optic disk melanocytoma with systemic hypertension. CASES: Ocular examination of 3 asymptomatic hypertensive patients revealed a pigmented lesion over the optic disk. After clinical examination and radiological evaluation a diagnosis of optic disk melanocytoma was made. One patient had a mild decrease in visual acuity associated with an increase in size of the lesion during the follow-up. Systemic evaluation revealed increased urinary vanillylmandelic acid in all the patients. MRI showed diffuse adrenal hyperplasia while a (131)I-MIBG scan showed increased uptake in 1 case. CONCLUSIONS: Optic disk melanocytoma is a benign tumor though the lesion may increase in size with the resultant decrease in visual acuity over few years. It may be associated with systemic hypertension secondary to increased levels of catecholamines in the body, which is related to the common neural crest origin of melanocytes, adrenal medullary cells and chromaffin cells.

Adult↗
PubMed2005

Bilateral angle closure glaucoma following snake bite.

Snake venoms are complex heterogenous poisons with multiple effects. Ocular complications with snake bite are rare. This report describes two cases which developed bilateral acute angle closure glaucoma following snake bite. There was complete recovery in the two patients following timely diagnosis and treatment.

Adult↗
PubMed2002

Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery.

PURPOSE: To compare the effect of topical ketorolac tromethamine 0.5% solution and topical diclofenac sodium 0.1% solution on the inhibition of surgically induced miosis. SETTING: Tertiary care teaching hospital in South India. METHODS: Fifty-one patients were prospectively randomized to receive ketorolac 0.5% or diclofenac 0.1% at 3 intervals preoperatively. Patients with diabetes mellitus, pseudoexfoliation, or local pupil abnormalities were excluded from the study. Mydriatics comprising homatropine 1% plus phenylephrine 10% were instilled in all patients 1 hour before the peribulbar block at 5 intervals. Horizontal pupil diameters were obtained at the beginning of surgery, after capsulotomy, after intraocular lens (IOL) implantation, and at the end of surgery. RESULTS: The mean horizontal pupil diameter was 7.40 mm at the start of surgery in both groups. The ketorolac group showed a consistent trend toward larger pupil diameters at subsequent surgical intervals. Changes from baseline also indicated more significant inhibition of miosis in the ketorolac group. CONCLUSIONS: Topical ketorolac was a more effective inhibitor of miosis than topical diclofenac during extracapsular cataract extraction and IOL implantation. It also provided a more stable mydriatic effect throughout surgery.

Administration, Topical↗
PubMed2002

Posterior chamber intraocular lens supported by an intact vitreous face.

We describe a technique of posterior chamber intraocular lens (IOL) implantation in eyes with inadequate capsule support caused by inadvertent or planned intracapsular cataract extraction (ICCE) or in eyes having secondary IOL implantation after previous ICCE. The procedure is only performed in eyes with an intact anterior vitreous face, no vitreous prolapse into the anterior chamber, and no vitreous loss. The anterior vitreous is pushed back by viscoelastic material or air. The viscoelastic material is injected under the iris to create a free space between the iris and anterior vitreous. A single-piece, C-loop, poly(methyl methacrylate) IOL is slid onto the iris to rest on the anterior vitreous face; care is taken not to disturb the anterior vitreous. The technique was used in 15 eyes with a follow-up from 19 months to 5 years. All eyes had a stable IOL at each follow-up, and the visual acuity was 6/12 or better at the last follow-up.

Adult↗
PubMed2002

Microbial contamination of the anterior chamber during phacoemulsification.

PURPOSE: To study the nature and frequency of anterior chamber contamination during phacoemulsification. SETTING: Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. METHODS: Eighty eyes of 80 patients having routine phacoemulsification cataract surgery were recruited into this prospective study. Bacterial cultures from the intraoperative anterior chamber aspirates from the patients were assessed. RESULTS: Anterior chamber fluid aspirates were positive for bacteria in 37 eyes (46.25%). Coagulase-negative Staphylococcus was the most common aerobe and Propionibacterium acnes, the most common anaerobe. CONCLUSION: Results indicate that phacoemulsification has no proven advantage over conventional extracapsular cataract extraction in reducing intraoperative bacterial contamination.

Anterior Chamber↗