Biomedical subjects

Richard C Wilson

Publications and source records attributed to Richard C Wilson.

6 recordsLinked to original sources

PubMed2006

Water incident related hospital activity across England between 1997/8 and 2003/4: a retrospective descriptive study.

BACKGROUND: No one has ever reported or investigated the number of people who have been admitted to hospital for a water related incident. The purpose of this paper is to examine, the hospital activity resulting from such incidents including to length of stay, gender, age and cause. METHODS: The data was extracted from the Hospital Episode Statistics (HES) for episodes with a mention of ICD 10 (V90-94, W15-16, W65-74, X38, X92, Y21) for the years 1997/8 to 2003/4. Population based rates and relative risk were calculated using the most recent Census data for England (2001). RESULTS: The 6,793 episodes resulted in a total of 32,520 bed days with an average of length of stay of 5.0 days. Males made up 73.7% (n = 5,006) of episodes and females 26.1% (n = 1,787). Annual trends peaked in 1999-2000 at a rate of 2.4 per 100,000 and have fluctuated on alternate years there after. In terms of relative risk males are at a 2.3 to 3.0 increased annual risk of being admitted compared to females, relating to a water event. The highest annual rates were observed within the 0 - 14 age group, ranging from 3.1 to 4.2 episodes per 100,000. CONCLUSION: Based on these findings, for every one drowning that occurs per year there are three hospital episodes. Each of the age groups identified within the study reported an increase in hospital episodes between 2002 - 2003 and 2003 - 2004, when considering the fatality information available it would appear that although fatalities are decreasing in the similar time period, hospital episodes are increasing. For the 0-14 age group, the cause of the injury had changed over the years, moving away from bath tub and swimming pool, to watercraft incidents (V91 - 93). For the 15 - 59 age group there had been a decline in the frequency of watercraft and water transport episodes, however, an increase in diving and jumping injury and incidents. In the over 60 age group water transport episodes remained the most frequent, with swimming pool related episodes declining and other specified drowning and submersion increasing. More work needs to be undertaken in regard to who is admitted to hospital, when where, and how to fill gaps in knowledge and highlight information that is critical to prevention strategies.

Adolescent↗

PubMed2005

Development and performance of the diffusive gradients in thin-films technique for the measurement of technetium-99 in seawater.

A novel technique for obtaining time-integrated 99Tc concentrations in seawater has been developed, using diffusive gradients in thin films (DGT). The performance of TEVA resin as a binding agent for 99Tc was investigated via laboratory experiments. The accumulated 99Tc activity per unit area of resin-gel was proportional to both the bulk solution activity and the exposure time for deployments of up to 2 weeks. The response of DGT was found to be independent of solution chemistries over the pH range 3-8 and ionic strength range 0.01-1.3 M. Seawater has pH 8 and ionic strength of approximately 0.7 M; therefore, the potential of the technique for field deployment in seawater was demonstrated. Detection limits of 0.05 and 0.025 Bq L(-1), for 2- and 4-week DGT deployments, respectively, were calculated for 99Tc measurement by liquid scintillation spectrometry. Using quadrupole ICPMS to measure bound 99Tc could reduce these detection limits to 0.125 mBq L(-1) for a 4-week deployment. These detection limits are sufficiently low for monitoring contaminated environments, including the Irish Sea. This method is simpler and faster than other 99Tc analysis methods and represents the only means of obtaining time-integrated data.

Journal Article↗

PubMed2005

Pattern vectors from algebraic graph theory.

Graph structures have proven computationally cumbersome for pattern analysis. The reason for this is that, before graphs can be converted to pattern vectors, correspondences must be established between the nodes of structures which are potentially of different size. To overcome this problem, in this paper, we turn to the spectral decomposition of the Laplacian matrix. We show how the elements of the spectral matrix for the Laplacian can be used to construct symmetric polynomials that are permutation invariants. The coefficients of these polynomials can be used as graph features which can be encoded in a vectorial manner. We extend this representation to graphs in which there are unary attributes on the nodes and binary attributes on the edges by using the spectral decomposition of a Hermitian property matrix that can be viewed as a complex analogue of the Laplacian. To embed the graphs in a pattern space, we explore whether the vectors of invariants can be embedded in a low-dimensional space using a number of alternative strategies, including principal components analysis (PCA), multidimensional scaling (MDS), and locality preserving projection (LPP). Experimentally, we demonstrate that the embeddings result in well-defined graph clusters. Our experiments with the spectral representation involve both synthetic and real-world data. The experiments with synthetic data demonstrate that the distances between spectral feature vectors can be used to discriminate between graphs on the basis of their structure. The real-world experiments show that the method can be used to locate clusters of graphs.

Algorithms↗

PubMed2004

Material deprivation, hospitalisation and adverse events temporally associated with immunisation.

We examined hospital admissions for illness temporally associated with childhood immunisations to determine the influence of material deprivation. Children aged <5 years hospitalised in the West Midlands were identified using ICD10 codes (Y580-Y599) from April 1995 through March 2000. Material deprivation was measured using the Townsend score. Children from deprived areas were at increased risk (OR = 4.49, 95% CI 3.14-7.78) compared to children from affluent areas and, were more likely to be admitted following immunisation with pertussis vaccine (OR = 5.91, 95% CI 2.69-12.29). Further research is required to determine the contribution of healthcare providers and parents to this health differential.

Child, Preschool↗

PubMed2003

Rural/urban differences in the association between deprivation and healthcare utilisation.

Whilst associations between inequalities in healthcare utilisation and socio-economic deprivation are well established in the UK it is argued that deprivation indices, such as the Townsend index, remain insensitive to rural/urban differences. This study examines how Townsend and its components differ in their association with healthcare utilisation across the rural/urban spectrum of a large health region. Our research was carried out in the West Midlands National Health Service region (population 5.3 million), comprising of a similar geographical population diversity to that of the United Kingdom (UK) using Hospital Episode Statistics (1994/5-1998/9) and 1991 census socio-demographic data. Retrospective multilevel multivariate models compare three ward-level healthcare utilisation measures (standardised episode-, admission-, and bed-rates) in relation to the Townsend index of material deprivation, its components, and four rural/urban characteristics (population density, population potential, electoral ward area and perimeter size). The associations between outcomes and Townsend were generally not attenuated by the rural/urban characteristics. The constituent component of car-ownership was similarly unperturbed, whereas population potential significantly perturbed the home-ownership model and overcrowding was significantly perturbed by all four rural/urban characteristics considered. A deprivation index may encapsulate different meanings to that of its components when used to assess variations in healthcare utilisation. Constituent components may yield considerable perturbation in relation to healthcare utilisation across the rural/urban spectrum, whilst the composite measure does not. In particular, and contrary to anecdotal opinion, car-ownership and unemployment (as recorded in the 1991 UK census) exhibited a stable relationship across different rural/urban areas with respect to healthcare utilisation.

Automobiles↗

PubMed2003

Social deprivation and hospital admission for respiratory infection: an ecological study.

STUDY OBJECTIVE: To examine the relationship between social deprivation and risk of hospital admission for respiratory infection. METHODS AND SUBJECTS: Ecological study using hospital episode statistics and population census data. Cases were residents of the West Midlands Health Region admitted to hospital with a diagnosis of respiratory infection, acute respiratory infection, pneumonia or influenza over a 5-year period. Postcodes of cases were used to assign Townsend deprivation scores; these were then ranked and divided into five deprivation categories. Poisson regression analysis was used to estimate the magnitude of effect for associations between deprivation category and hospital admission by age and admitting diagnosis. MAIN RESULTS: There were 136755 admissions for respiratory infection, equivalent to an annual admission rate of 27.1 per 1000 population (95% CI = 26.9-27.2). Deprivation was associated with increased admission rates for all respiratory infection (P < 0.0001) and affected all age-groups. The greatest effect was in the 0-4 years age-group with admission rates 91% higher in the most deprived children compared to the least deprived. Hospital admissions for acute respiratory infection and pneumonia were both significantly associated with deprivation (P < 0.0001). CONCLUSIONS: Respiratory infection is associated with social inequalities in all age-groups, particularly in children. Prevention of respiratory infection could make an important contribution to reducing health inequalities.

Acute Disease↗