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Biomedical subjects

Richard Davenport

Publications and source records attributed to Richard Davenport.

3 recordsLinked to original sources

Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens.

Investigation of Pseudomonas syringae pv. coronafaciens cancer cell growth inhibitory constituents led to the isolation of 2-isobutyl-5-(3-indolyl)oxazole (1) and 2-n-pentyl-5-(3-indolyl)oxazole (2f), designated labradorins 1 (1) and 2 (2f), related to pimprinine (2a). The structures were deduced by spectroscopic techniques and X-ray crystal structure determinations. Labradorin 1 (1) afforded GI(50) microg/mL values of 9.8 and 6.2 against the human cancer cell lines NCI-H 460 (lung-NSC) and BXPC-3 (pancreas-a).

Crystallography, X-Ray↗

Diagnosing acute headache.

Acute onset headache is common. Most such patients do not have a sinister underlying cause, but some do. The key to deciding who requires investigation and who does not lies in the history. All patients presenting with headache maximal immediately or within a few minutes and lasting longer than an hour, require investigations (computed tomography brain scan +/- lumbar puncture) to exclude subarachnoid haemorrhage.

Acute Disease↗