PubMed Health⌕ Search

Biomedical subjects

Richard Derner

Publications and source records attributed to Richard Derner.

2 recordsLinked to original sources

The bone morphogenic protein.

The molecular and cellular process to promote bone formation has been examined extensively in recent years in an attempt to minimize delayed unions and nonunions. Bone morphogenetic proteins (BMPs) have been determined to play an intricate role in the bone formation cascade. Over 14 BMPs have been isolated and more are being discovered as investigation progresses. BMP-2 and BMP-7 are being produced commercially for clinical use with specific indications. Continuing research is investigating the optimal carrier that will give the best results. This article reviews the most current information regarding BMPs.

Animals↗

A plantar-flexor-shortening osteotomy for hallux rigidus: a retrospective analysis.

This retrospective study reported the clinical and radiographic findings of a plantar-flexor-shortening first metatarsal osteotomy for treatment of hallux rigidus. Twenty-six patients (33 feet) were evaluated with a mean 34.4 months follow-up (range, 18-65 months). Assessment consisted of clinical measurements of total range of first metatarsophalangeal joint motion and radiographic measurements of first metatarsophalangeal joint space, including plantarflexion and shortening of the first metatarsal. Patients were evaluated postoperatively using the American Orthopedic Foot and Ankle Society's Hallux Metatarsophalangeal-Interphalangeal Scoring System. The mean preoperative first metatarsophalangeal joint total range of motion was 33.5 degrees (5 degrees -60 degrees ), and postoperatively increased to 72.1 degrees (50-100 degrees ), a mean increase of 38.6 degrees at follow-up (range, 25 degrees -60 degrees ) (P < .001). This range of motion was observed despite a lack of significant improvement in radiographic joint space measurements, (preoperative mean 1.26; postoperative mean 1.82). Postoperative radiographs also demonstrated 1-4 mm of plantarflexion of the first metatarsal head, and a mean 6.1 mm shortening of the first metatarsal. At last follow-up, 85% (22/26) of patients rated their result as very good to excellent, 8% (2/26) reported a good result, 4% (1/26) a fair result, and 4% (1/26) a poor result. The mean postoperative rating scale score was 78.1/100. No patient required revisional surgery for hallux rigidus. Four patients had postoperative lesser metatarsalgia, 3 of which were self-limiting, and one that resolved following surgery. The results of this study show the plantar-flexor-shortening first metatarsal to be an effective surgical treatment for hallux rigidus with reproducible deformity correction and patient satisfaction.

Adult↗