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Biomedical subjects

Richard G Perrin

Publications and source records attributed to Richard G Perrin.

7 recordsLinked to original sources
PubMed2006

The timing of surgical intervention in the treatment of spinal cord injury: a systematic review of recent clinical evidence.

STUDY DESIGN: Evidence-based literature review. OBJECTIVE: To provide updated evidence-based recommendations regarding spinal cord decompression in patients with acute spinal cord injury (SCI). SUMMARY OF BACKGROUND DATA: It is controversial whether early decompression following SCI conveys a benefit in neurologic outcome. METHODS: MEDLINE search of experimental and clinical studies showing the effect of decompression on neurologic outcome following SCI. We focused on articles published within the last 10 years, with a particular emphasis on research conducted within the past 5 years. RESULTS: A total of 66 articles were retrieved. Animal studies consistently show that neurologic recovery is enhanced by early decompression. There was 1 randomized controlled trial that showed no benefit to early (<72 hours) decompression. Several recent prospective series suggest that early decompression (<72 hours) can be performed safely and may improve neurologic outcomes. A recent systematic review showed that early decompression (<24 hours) resulted in statistically better outcomes compared to both delayed decompression and conservative treatment. CONCLUSIONS: There are currently no standards regarding the role and timing of decompression in acute SCI. We recommend urgent decompression of bilateral locked facets in a patient with incomplete tetraplegia or in a patient with SCI with neurologic deterioration. Urgent decompression in acute cervical SCI remains a reasonable practice option and can be performed safely. There is emerging evidence that surgery within 24 hours may reduce length of intensive care unit stay and reduce post-injury medical complications.

Animals↗
PubMed2006

Cordectomy for the treatment of posttraumatic syringomyelia. Report of four cases and review of the literature.

Cordectomy is an effective treatment option in patients in whom posttraumatic syringomyelia develops following complete spinal cord injuries. Since the introduction of cordectomy, numerous approaches to the surgical treatment of posttraumatic syringomyelia have been developed. These newer developments have drawn the attention of surgeons and researchers away from cordectomy. In this report, the authors encourage a reconsideration of cordectomy for the treatment of posttraumatic syringomyelia after complete spinal cord injury. They describe four patients with posttraumatic syringomyelia who were treated successfully with cordectomy and review appropriate literature, examining the effectiveness of cordectomy in the treatment of posttraumatic syringomyelia. The findings of this review indicate that neurological improvement or stabilization occurred in 88% of patients in published reports of posttraumatic syringomyelia treated with cordectomy. The indications for cordectomy as well as factors that may contribute to the procedure's success are discussed.

Adult↗
PubMed2005

The role and timing of early decompression for cervical spinal cord injury: update with a review of recent clinical evidence.

It remains controversial whether early decompression following spinal cord injury conveys a benefit in neurological outcome. The goal of this paper is to provide evidence-based recommendations regarding spinal cord decompression in patients with acute spinal cord injury. We performed a Medline search of experimental and clinical studies reporting on the effect of decompression on neurological outcome following spinal cord injury. Animal studies consistently show that neurological recovery is enhanced by early decompression. One randomized controlled trial showed no benefit to early (<72 h) decompression, however, several recent prospective series suggest that early decompression (<12 h) can be performed safely and may improve neurological outcomes. A recent meta-analysis showed that early decompression (<24 h) resulted in statistically better outcomes compared to both delayed decompression and conservative management. Currently, there are no standards regarding the role and timing of decompression in acute spinal cord injury. We recommend urgent decompression of bilateral locked facets in patients with incomplete tetraplegia or in patients with spinal cord injury experiencing neurological deterioration. Urgent decompression in acute cervical spinal cord injury remains a reasonable practice option and can be performed safely.

Acute Disease↗
PubMed2005

Tension pneumoventricle after placement of a ventriculoperitoneal shunt: a novel treatment strategy. Case report.

A case of pneumoventricle following insertion of a ventriculoperitoneal shunt for hydrocephalus is described. The pneumoventricle was associated with significant morbidity, which improved with treatment. The authors propose a rational treatment for this condition, which, as far as they know, has not previously been described. They also discuss potential mechanisms involved in the pathogenesis of pneumoventricle.

Central Nervous System Cysts↗
PubMed2004

Malignant peripheral nerve sheath tumors.

The rarity of MPNSTs and the lack of any singular diagnostic radiologic or pathologic signature lead to several management challenges. These tumors are best managed as part ofa multidisciplinary team so as to optimize patient care and facilitate research. Suspicion of an MPNST based on clinical or radiologic alteration of a soft tissue mass in proximity to a peripheral nerve, especially in the context of NF I, should lead to referral to such a tertiary center. Early diagnosis followed by oncologic surgery to obtain tumor-free margins provides the best chance for long-term cure. Psychologic support and occupational rehabilitation are vital components of the overall care of these relatively young patients faced with often disabling surgery. Current adjuvant therapy with radiation and chemotherapy is suboptimal. There have been major inroads toward the molecular biologic understanding of MPNSTs,with several biologic targets that are of potential therapeutic interest. Proper evaluation of these novel and promising management strategies requires a concerted effort to refer these patients to the tertiary centers through which multi-institutional clinical trials can be undertaken.

Humans↗
PubMed2004

Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients.

Spinal metastasis is the most commonly en-countered tumor of the spine and represents an ominous extension of neoplastic disease. Symptomatic spinal metastases produce a characteristic clinical syndrome beginning with local back or neck pain. All too often, the significance of presenting pain is not appreciated and correct diagnosis is delayed until more blatant manifestations of spinal cord or nerve root dysfunction are manifest. Pain is followed by weakness,numbness, and sphincter dysfunction. The natural history is one of relentless progression to complete and irreversible paralysis unless timely treatment is undertaken. Plain radiographs provide a simple and useful screening test. MRI is, however, the imaging method of choice, providing information concern-ing the level, location, and geometry of the spinal tumor as well as details concerning the bony integrity of the spine, particularly adjacent to a culpable tumor, all of which is essential to determine the management options and treatment strategies. Percutaneous image-guided biopsy is a useful test to establish a tissue diagnosis.

Humans↗