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Richard Russell

Publications and source records attributed to Richard Russell.

5 recordsLinked to original sources

Sex, beauty, and the relative luminance of facial features.

It has been suggested that the consistent luminance difference between the darker regions of the eyes and mouth and the lighter regions that surround them forms a pattern unique to faces. One of the more consistent uses of cosmetics to make the female face more attractive is to darken the eyes and mouth relative to the surrounding skin. The hypothesis that the size of the luminance difference between the eyes and mouth and the rest of the face affects the attractiveness of male and female faces differently was tested in four experiments in which attractiveness ratings were obtained for images of faces in which the luminance difference between the eyes and mouth and the rest of the face had been manipulated. Female faces were found to be more attractive when this luminance difference was increased than when it was decreased, and the opposite was found for male faces. An interpretation consistent with these results is that the luminance difference between the eyes and mouth and the rest of the face is naturally greater in women than men. In this case increasing or decreasing the luminance difference will make a face more feminine or masculine, respectively, and hence, more or less attractive depending on the sex of the face. Implications for the causes of cosmetics usage are discussed.

Adult↗

Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids.

BACKGROUND: Asthma is associated with remodeling of the extracellular matrix (ECM) and increased airway obstruction, and the mechanisms of this process are unknown. Matrix metalloproteinases (MMPs) are a group of enzymes capable of degrading the ECM. They are released along with their inhibitors, tissue inhibitor of MMP (TIMP). STUDY OBJECTIVE: s: To determine whether severe, persistent asthma is associated with increased levels of MMP-9 in the airway compared with mild asthma, and to assess the effect of both allergen exposure and steroid treatment on MMP-9 and TIMP-1 levels. DESIGN: Prospective analysis of levels and activity of MMP-9 and TIMP-1 in BAL fluid (BALF) and induced sputum obtained from asthmatics of differing disease severity. In patients with mild asthma, MMP-9 and TIMP-1 levels were studied in induced sputum following allergen challenge and in BALF after inhaled steroid therapy. PATIENTS: Eighteen patients with mild asthma, 10 patients with severe asthma, and 10 nonsmoking, atopic subjects had their sputum studied. Fourteen of the patients with mild asthma underwent allergen challenge. BAL was collected from 16 patients with mild asthma before and after 4 weeks treatment with inhaled budesonide, 800 micro g bid, or placebo. RESULTS: Patients with severe asthma had increased levels and activity of sputum MMP-9 in their sputum compared with patients with mild asthma and normal subjects. Allergen challenge increased the MMP-9/TIMP-1 ratio and MMP-9 activity. Inhaled budesonide had no effect on MMP-9 or TIMP-1 in patients with mild asthma. CONCLUSIONS: MMP-9 may play a role in chronic airway inflammation and remodeling in asthma, as concentrations are increased in severe, persistent asthma and following allergen challenge. Inhaled steroids may not affect MMP-9 and TIMP in patients with mild asthma, and additional studies in patients with more severe asthma are needed.

Administration, Inhalation↗

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