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Biomedical subjects

Rick Fry

Publications and source records attributed to Rick Fry.

3 recordsLinked to original sources

Cardiovascular Disease.

HEALTH ISSUE: Cardiovascular disease (CVD) is the leading cause of death in Canadian women and men. In general, women present with a wider range of symptoms, are more likely to delay seeking medial care and are less likely to be investigated and treated with evidence-based medications, angioplasty or coronary artery bypass graft than men. KEY FINDINGS: In 1998, 78,964 Canadians died from CVD, almost half (39,197) were women. Acute myocardial infarction, which increases significantly after menopause, was the leading cause of death among women.Cardiovascular disease accounted for 21% of all hospital admissions for Canadian women over age 50 in 1999. Admissions to hospital for ischemic heart disease were more frequent for men, but the mean length of hospital stay was longer for women.Mean blood pressure increases with age in both men and women. After age 65, however, high blood pressure is more common among Canadian women. More than one-third of postmenopausal Canadian women have hypertension.Diabetes increases the mortality and morbidity associated with CVD in women more than it does in men. Depression also contributes to the incidence and recovery from CVD, particularly for women who experience twice the rate of depression as men. DATA GAPS AND RECOMMENDATIONS: CVD needs to be recognized as a woman's health issue given Canadian mortality projections (particularly heart failure). Health professionals should be trained to screen, track, and address CVD risk factors among women, including hypertension, elevated lipid levels, smoking, physical inactivity, depression, diabetes and low socio-economic status.

Journal Article↗

Residential proximity to industrial plants and non-Hodgkin lymphoma.

BACKGROUND: A U.S. analysis suggested a relation between self-reported residential proximity to industrial plants and non-Hodgkin lymphoma (NHL) risk. METHODS: Using lifetime residential histories collected from a population-based sample of 1499 Canadians with newly diagnosed, histologically confirmed NHL and 5039 population controls, we evaluated the association of residential proximity to 7 types of major heavy industry with NHL risk. RESULTS: Overall, having lived within 0.8 km or within 3.2 km of an industrial plant was not associated with increased NHL risk. For the follicular subtype of NHL, an odds ratio (OR) of 1.48 (95% confidence interval [CI] = 1.10-1.99) was observed for women who had lived within 3.2 km (83 cases/689 controls). ORs for NHL were elevated for proximity within 3.2 km of copper smelters (OR = 5.1; CI = 1.5-17.7; 7 cases, 4 controls) and within 0.8 km of sulfite pulp mills (OR = 3.7; CI = 1.5-9.4; 9 cases, 10 controls). CONCLUSIONS: We have identified possible associations between NHL and proximity to industrial plants, which could be the result of chance or other factors associated with proximity. Studies are needed to confirm these associations and to determine whether residential proximity can result in meaningful exposure.

Adult↗

Animal-related occupations and the risk of leukemia, myeloma, and non-Hodgkin's lymphoma in Canada.

OBJECTIVE: There is some evidence to suggest that workers in animal-related occupations are at increased risk of developing lymphohematopoietic cancers. This study aimed to examine the risk of leukemia, non-Hodgkin's lymphoma (NHL), and multiple myeloma associated with occupational exposure to animals. METHODS: We used data from a multi-site, population-based case-control study using mailed questionnaires which had taken place in eight of ten Canadian provinces, during 1994-1998. There were 1023 leukemia cases, 1577 NHL cases, and 324 multiple myeloma cases (all histologically confirmed) and 4688 population-based controls. Animal-related occupations were identified from a lifetime occupational history. Subjects in animal-related jobs were compared with others using logistic regression for the risk of leukemia, NHL, and multiple myeloma. RESULTS: Compared to subjects without occupational exposure to animals, occupational exposure to beef cattle increased the risks of leukemia (odds ratio (OR) 2.0, 95% confidence interval (CI) 1.2-3.3) and NHL (OR 1.8, 95% CI 1.1-2.9). No other animal exposure was consistently associated with risk of lymphohematopoietic cancer. An unexpected protective association was observed between work as a fisherman and leukemia (OR 0.4, 95% CI 0.2-0.8) and NHL (OR 0.6, 95% CI 0.4-0.9). CONCLUSIONS: This population-based case-control study found that those individuals working in occupations associated with beef cattle are at increased risk for developing leukemia and lymphoma while those working in occupations requiring the handling of fish are at decreased risk of leukemia and lymphoma.

Adult↗