Biomedical subjects

Robert E Frank

Publications and source records attributed to Robert E Frank.

3 recordsLinked to original sources

PubMed2005

Cranial artery dissection.

Stroke is a very common cause for mortality and morbidity, especially in the elderly where the cause is usually generalized arteriosclerosis. In persons less than 45 years of age with stroke, there is a group of uncommon illnesses that are often identified. This includes cranial artery dissection, accounting for approximately 20% of these acute neurological events. Cranial artery dissection can involve the carotids or vertebral system, and symptoms can be quite diverse depending on the area of brain ischemia. Anticoagulation is the usual treatment, and overall there is a good long-term prognosis from this entity.

Adult↗

PubMed2004

Cystic fibrosis--a genetic dilemma.

Cystic fibrosis is a common genetic disease that usually presents in early childhood as a devastating disease affecting pulmonary function and at times gastrointestinal functioning and nutritional status. Variant forms of this disease have been described, which may have a delayed age of onset or a milder clinical course. Numerous genetic mutations have been described in cystic fibrosis. There are several mutations that are known to be associated with late onset disease or mild clinical disease. Research continues into these genetic mutations and various modifiers that may help to more accurately predict the final phenotypic presentation.

Actuarial Analysis↗

PubMed2002

Autoimmune hepatitis.

Autoimmune hepatitis is an uncommon disease causing chronic inflammation of the liver and associated with various circulating autoantibodies. It shares some characteristics with other autoimmune liver diseases, such as primary biliary cirrhosis and sclerosing cholangitis. There has been confusion in past years regarding this entity, but there are now recognized diagnostic criteria by which to make a proper diagnosis. The disease is usually treatable with steroids. Certain proportions of treated patients become cured, although relapse is a problem often requiring chronic administration of steroid therapy. The expected mortality is close to normal in individuals who are cured or have only mild disease.

Biopsy↗