Biomedical subjects

Robert F Burkard

Publications and source records attributed to Robert F Burkard.

6 recordsLinked to original sources

PubMed2003

Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA.

The protective effects of glutathione monoethylester (GEE) and GEE in combination with R-N6-phenylisopropyladenosine (R-PIA) were evaluated in the chinchilla when exposed to impulse (145 dB pSPL) or continuous (105 dB SPL, 4 kHz OB) noise. Six groups of 10 chinchillas were used as subjects. Before exposure to noise, the subjects were anesthetized, a 30 microl drop of drug was placed on the round window (GEE [50, 100, 150 mM], GEE 50 mM and R-PIA). Forty minutes later the subject was exposed to either impulse or continuous noise. The 50 mM treatment provided significant protection from impulse noise, but not from continuous noise exposure. The combination provided significant protection from both the continuous and impulse noise. In a separate set of experiments, glutathione (GSH) levels were measured in the perilymph. All the drug treatments elevated GSH levels. The results are discussed in terms of antioxidant treatments as a prophylactic measure against noise-induced hearing loss.

Adenosine↗

PubMed2003

Development of materials for the clinical assessment of speech recognition: the speech sound pattern discrimination test.

The purpose of this investigation was to evaluate the validity and reliability of materials designed for an assessment procedure capable of making meaningful distinctions in speech recognition ability among individuals having mild-to-moderate hearing losses. Sets of phonetic contrasts were presented within sentence contexts to 53 listeners (22 normal hearing, 31 hearing impaired) in 4 listening conditions (quiet and with background competition at signal-to-noise ratios of +5, 0, and -5 dB). The listeners were asked to discriminate pairs of sentences (e.g., "The man hid the dog" and "The man hit the dog") using same-different judgments. Their performances were analyzed in a manner enabling comparisons among items in terms of the classification of phonetic contrasts. Listener performance was also compared to performance on a set of independent variables, including the W-22 and QuickSIN speech tests, high-frequency hearing loss, speech reception threshold, listener age, and others. Results indicated that the new materials distinguished the normal-hearing from the hearing-impaired group and that listener performance (a) declined about 17% for each 5 dB decrement in SNR and (b) was influenced by the phonetic content of items in a manner similar to that reported by G. A. Miller and P. E. Nicely (1955). The performances of the hearing-impaired listeners were much more strongly related to high-frequency hearing loss, listener age, and other variables than were their performances on either the W-22 or QuickSIN tests. These findings are discussed with specific reference to the use of a mathematical model (i.e., the Rasch model for person measurement) for scaling items along a continuum of difficulty. The mathematical model and associated item difficulty values will serve as the basis for construction of a clinically useful computerized, adaptive test of speech recognition ability known as the Speech Sound Pattern Discrimination Test (Bochner, J., Garrison, W., Palmer, L., MacKenzie, D., & Braveman, A., 1997).

Adult↗

PubMed2002

Tinnitus.

Explore the source record for details and available documents.

Algorithms↗

PubMed2002

Stimulus and recording variables and their effects on mammalian vestibular evoked potentials.

Linear vestibular evoked potentials (VsEPs) measure the collective neural activity of the gravity receptor organs in the inner ear that respond to linear acceleration transients. The present study examined the effects of electrode placement, analog filtering, stimulus polarity and stimulus rate on linear VsEP thresholds, latencies and amplitudes recorded from mice. Two electrode-recording montages were evaluated, rostral (forebrain) to 'mastoid' and caudal (cerebellum) to 'mastoid'. VsEP thresholds and peak latencies were identical between the two recording sites; however, peak amplitudes were larger for the caudal recording montage. VsEPs were also affected by filtering. Results suggest optimum high pass filter cutoff at 100-300 Hz, and low pass filter cutoff at 10,000 Hz. To evaluate stimulus rate, linear jerk pulses were presented at 9.2, 16, 25, 40 and 80 Hz. At 80 Hz, mean latencies were longer (0.350-0.450 ms) and mean amplitudes reduced (0.8-1.8 microV) for all response peaks. In 50% of animals, late peaks (P3, N3) disappeared at 80 Hz. The results offer options for VsEP recording protocols.

Animals↗

PubMed2002

Brain imaging of the effects of lidocaine on tinnitus.

Using a single-blind placebo-controlled design, we mapped lidocaine related changes in neural activity, measured by regional cerebral blood flow (rCBF) with (15)O-H(2)O positron emission tomography. Intravenous lidocaine produced both increases and decreases in the loudness of tinnitus. The change in tinnitus loudness was associated with a statistically significant change in neural activity in the right temporal lobe in auditory association cortex. Decreases in tinnitus loudness resulted in larger changes in rCBF than increases. The unilateral activation pattern associated with tinnitus, in contrast with the bilateral activation produced by a real sound, suggests that tinnitus originates in the central auditory system rather than the cochlea. In addition, generalized lidocaine effects were found in the basal ganglia, thalamus, and a region spanning the Rolandic fissure.

Acoustic Stimulation↗

PubMed2002

A comparison of the effects of broadband masking noise on the auditory brainstem response in young and older adults.

We examined the effects of ipsilateral-direct, continuous, broadband noise on auditory brainstem response (ABR) wave I and V latencies and amplitudes in young adult versus older adult humans. It was hypothesized that age might influence the effects of masking noise on ABR peak latencies and/or amplitudes, given the frequent complaint of older persons' ability to process speech in background noise. Young adults had hearing thresholds of 20 dB HL or better for the octave frequencies from 250 to 8,000 Hz. A subset of older study participants had thresholds of 20 dB HL or better across frequency, but others had thresholds up to 45 dB HL. All data were collected and analyzed with a Nicolet Bravo. An electrode was placed on the tympanic membrane (as well as on high forehead and contralateral mastoid), and a click level of 115 dB pSPL was used to maximize wave I amplitude. Masker conditions included a no-noise control and noise levels ranging from 20 to 70 dB effective masking, in 10 dB steps. With increasing noise level, both age groups showed minimal changes in wave I latency, but substantial increases in wave V latency and I-V interval. Peak amplitudes decreased with increasing noise level. Mean amplitudes were smaller for the older group, most notably for wave I. Mean peak latencies were greater in the older group, but the I-V interval was similar across age groups, as was the change in peak latencies and I-V interval across noise level. ABR parameters for the older adults with hearing meeting the 20-dB HL criterion at all frequencies (older-better) were compared to those who didn't meet this criterion (older-worse). Mean wave I latency was greater and wave V latency and I-V interval were smaller for the older-worse group at all noise levels. Mean wave I and V amplitudes were similar for the older-better and older-worse groups. In participants with normal or near-normal hearing, ABR changes with increasing age included small latency increases and a substantial reduction in wave I amplitude. The effects of ipsilateral-direct masking noise on the click-evoked ABR are similar for young and older adults.

Adult↗