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Biomedical subjects

Robert S Greenberg

Publications and source records attributed to Robert S Greenberg.

5 recordsLinked to original sources
PubMed2004

Childhood overweight: management approaches in young children.

Management of overweight in young children may be our best opportunity for confronting the nationwide epidemic of childhood obesity. Doing so will require all health care providers to improve their identification, assessment, and guidance on this issue. As a group, we must make it a priority to obtain height and weight measurements on every child and to interpret them correctly. We must be comprehensive in our medical investigation in order to uncover identifiable causes and recognize comorbidities. Most of all, we must motivate families, as a whole, to confront this issue with us by increasing physical activity, decreasing sedentary behaviors, and improving eating practices. As health professionals in a society that is not yet poised to fight this epidemic, we must lead the way.

Behavior Therapy↗
PubMed2002

Facemask, nasal, and oral airway devices.

Although this article merely glances the surface of some of the more fundamental aspects of managing the simple airway, one can see that an exhaustive discussion would require much more space than allotted herein. Although the author has attempted to reflect in a more clinically relevant tone in text, the best and most effective way to learn and remember such techniques is to perform them together with an experienced clinician. Attention to detail, subtleties, and nuances of the basic airway techniques, along with a willingness to refine this lost art of airway management, will re-solidify the foundation of excellent anesthesia and airway management.

Anesthesia↗
PubMed2002

Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists.

UNLABELLED: Anesthetic-induced hepatitis is thought to have an immune-mediated basis, in part because many patients who develop hepatitis have serum autoantibodies that react with specific hepatic proteins. The present study shows that pediatric anesthesiologists also have these serum autoantibodies. Moreover, levels of these autoantibodies are higher than those of general anesthesiologists. We collected sera from 105 pediatric and 53 general anesthesiologists (including 3 nurse anesthetists), 20 halothane hepatitis patients, and 20 control individuals who were never exposed to inhaled anesthetics. Serum cytochrome P450 2E1 (P450 2E1) and 58-kd hepatic endoplasmic reticulum protein (ERp58) autoantibodies were measured by enzyme-linked immunosorbent assays. Positive values were 2 SD above median control values. Two multiple regression models were constructed. Pediatric anesthesiologists, like halothane hepatitis patients, had higher serum autoantibody levels of ERp58 and P450 2E1 than general anesthesiologists and controls, which was possibly because of their increased occupational exposures to anesthetics. Female anesthesiologists had higher levels of ERp58 autoantibodies than male anesthesiologists, whereas female pediatric anesthesiologists had higher levels of P450 2E1 autoantibodies than all other anesthesiologists. One female pediatric anesthesiologist had symptoms of hepatic injury. Because most anesthesiologists do not develop volatile anesthetic-induced hepatic injury, the findings suggest that pathogenic ERp58 and P450 2E1 autoantibodies may not directly cause volatile anesthetic hepatitis. Female anesthesiologists have high levels of these autoantibodies; however, the majority of these individuals do not develop hepatitis, suggesting that autoantibodies may not have a pathological role in volatile anesthetic-induced hepatitis. IMPLICATIONS: Environmental exposure of anesthesiology personnel to certain inhaled anesthetics can induce the formation of autoantibodies that have been associated with anesthetic hepatitis. Female anesthesiologists have high levels of these autoantibodies; however, the majority of these individuals do not develop hepatitis, suggesting that autoantibodies may not have a pathological role in volatile anesthetic-induced hepatitis.

Adult↗