Biomedical subjects

Rochelle Dicker

Publications and source records attributed to Rochelle Dicker.

4 recordsLinked to original sources

PubMed2005

Clinical implementation of the ARDS network protocol is associated with reduced hospital mortality compared with historical controls.

OBJECTIVE: To assess the impact of implementing a low tidal volume ventilation strategy on hospital mortality for patients with acute lung injury or acute respiratory distress syndrome. DESIGN: Retrospective, uncontrolled study. SETTING: Adult medical-surgical and trauma intensive care units at a major inner city, university-affiliated hospital. PATIENTS: A total of 292 patients with acute lung injury or acute respiratory distress syndrome. INTERVENTIONS: Between the years 2000 and 2003, 200 prospectively identified patients with acute lung injury/acute respiratory distress syndrome were managed by the ARDS Network low tidal volume protocol. A historical control group of 92 acute respiratory distress syndrome patients managed by routine practice from 1998 to 1999 was used for comparison. MEASUREMENTS AND MAIN RESULTS: Patients managed with the ARDS Network protocol had a lower hospital mortality compared with historical controls (32% vs. 51%, respectively; p = .004). Multivariate logistic regression estimated an odds ratio of 0.32 (95% CI, 0.17-0.59; p = .0003) for mortality risk with use of the ARDS Network protocol. Protocol-managed patients had a lower tidal volume (6.2 +/- 1.1 vs. 9.8 +/- 1.5 mL/kg; p < .0001) and plateau pressure (27.5 +/- 6.4 vs. 33.8 +/- 8.9 cm H2O; p < .0001) than historical controls. CONCLUSION: Adoption of the ARDS Network protocol for routine ventilator management of acute lung injury/acute respiratory distress syndrome patients was associated with a lower mortality compared with recent historical controls.

APACHE↗

PubMed2005

Surgeon-performed bedside organ assessment with sonography after trauma (BOAST): a pilot study from the WTA Multicenter Group.

BACKGROUND: Although nonoperative management of solid organ injuries is a well-accepted practice, a rapid method to assess the progression of the injury, the early development of organ-related complications, and the frequency with which follow-up computed tomography (CT) scans are needed has yet to be determined. The use of ultrasound in this setting may provide information that would improve the rate of organ salvage and decrease the patient's morbidity. The objectives of this study were to determine whether surgeons could successfully use a bedside organ assessment with sonography after trauma (BOAST) examination to: (1) detect a solid organ injury; and (2) assess for changes in the size of the organ injury, an increase or decrease in hemoperitoneum, and the development of organ-related complications. METHODS: A prospective, multicenter study was conducted using BOAST to evaluate patients undergoing nonoperative management of their solid organ injuries. Patients had to have: (1) a Focused Assessment for Sonography of Trauma (FAST) examination on admission; (2) a solid organ injury documented by an admission abdominal CT scan; and (3) the criteria for nonoperative management. BOAST was performed within 24 hours of admission and every 3 to 4 days to evaluate for an increase or decrease in hemoperitoneum [Ultrasound (US) heme score: from 0 = none to 3 = large], change in injury size, and organ-specific complications. BOAST results were compared with the radiologists' interpretation of the initial and follow-up CT scans, and with patient outcomes. RESULTS: During a 22 month period, 126 patients sustained 135 solid organ injuries, 46 (34.1%) of these were seen by BOAST (Error rate = 66%). Serial US heme scores = 0 (no hemoperitoneum) were observed in 56 of 126 patients who had a combination of multi-system injury and a dropping Hgb, indicating that there was no further bleeding from the injured organ(s). Surgeons detected 13 of the 15 complications that were confirmed later by conventional imaging. CONCLUSIONS: (1) BOAST has limitations in identifying solid organ injuries, especially those that are lower grade; (2) the US heme score is a valuable adjunct to the clinical examination in following patients with high-grade solid organ injuries and a dropping hemoglobin; and (3) although uncommon, organ-related complications may be identified using BOAST.

Adolescent↗

PubMed2004

Splenic embolization revisited: a multicenter review.

BACKGROUND: Splenic embolization can increase nonoperative salvage. However, complications are not clearly defined. A retrospective multicenter review was performed to delineate the risks and benefits of splenic embolization. METHODS: A retrospective chart review of all patients undergoing splenic embolization from 1997 to 2002 at four separate Level I trauma centers was performed. Reviewed results included patient demographics, admission and follow-up computed tomographic scan results, angiographic technique, and patient outcomes including splenic salvage rate and procedural complications. RESULTS: A total of 140 patients were reviewed. The majority were young male patients involved in motor vehicle crashes. These patients had high abdominal computed tomographic grades of splenic injury and moderate Injury Severity Scores. The splenic salvage rate was 87%, which decreased with increasing injury grade. However, over 80% of splenic injury grades 4 and 5 were successfully managed nonoperatively. Significant hemoperitoneum did not affect success, but the presence of arteriovenous fistula was associated with a high failure rate, even with embolization. Salvage rates were similar between main coil and subselective embolization groups. Patients over 55 years of age did no worse than younger patients. Major complications included bleeding in 16 patients; 6 splenic abscesses, with 5 patients requiring splenectomy; and 1 episode of arterial injury requiring operative repair. CONCLUSION: Splenic embolization remains a valuable technique in splenic salvage, especially in higher grade injuries. Complications are common but do not seem to affect outcome.

Abdominal Injuries↗

PubMed2003

Trauma assessment training with a patient simulator: a prospective, randomized study.

BACKGROUND: Patient simulators are computer-controlled mannequins that may increase realism during trauma training by providing real-time changes in vital signs and physical findings during trauma scenarios. We hypothesized that trauma assessment training on a patient simulator would be as effective as training with a more traditional moulage patient/actor. METHODS: This study was conducted during a surgery intern orientation at two academic trauma centers. Interns (n = 60) attended a basic trauma course, and were then randomized to trauma assessment practice sessions with either the patient simulator (n = 30) or a moulage patient (n = 30). After practice sessions, interns were randomized a second time to an individual trauma assessment test on either the simulator or the moulage patient. Two surgeon-judges rated each intern live and on video for completion of 50 predetermined assessment objectives (total score) divided into sections (primary and secondary survey, general performance, diagnostic studies/procedures, and plan) and the identification and management of an acute neurologic deterioration in the test patient (event score). Multiple linear regression with random student effects was used to estimate the independent effects of all study variables. RESULTS: Within randomized groups, mean trauma assessment test scores for all simulator-trained interns were higher when compared with all moulage-trained interns (71 +/- 8 vs. 66 +/- 8, respectively; p = 0.02). Simulator training independently showed a small but statistically significant improvement in both the total score and the event score (+4.6 and +8.6, respectively; p < 0.05). CONCLUSION: Use of a patient simulator to introduce trauma assessment training is feasible and compares favorably to training in a moulage setting. Continued research in this area of physician education is warranted.

Educational Measurement↗