Biomedical subjects

Romain Quenardelle

Publications and source records attributed to Romain Quenardelle.

2 recordsLinked to original sources

PubMed2006

Unusually weak binding interactions in tetrazole-amidine complexes.

[reaction: see text] Tetrazoles frequently replace carboxylic acids in pharmaceutical drugs. However, while the binding modes of tetrazolate and carboxylate anions in amidinium complexes turns out to be similar, the association constant of the former is 2-3 orders of magnitude smaller in DMSO. Crystal structures revealed that the N...H-N hydrogen bonds in amidinium tetrazolates are bent (162 degrees and 169 degrees ) and noticeably longer (N...N 2.96 A) than corresponding hydrogen bonds in both amidinium carboxylates and ammonium tetrazolates.

Journal Article↗

PubMed2005

The first 4,1,10-MC2B10 supraicosahedral metallacarboranes and a route to previously inaccessible 4,1,12-ruthenium arene species.

Reduction of 1,12-closo-C2B10H12 or its C,C-dimethyl analogue with sodium in liquid ammonia followed by metallation with {CpCo}2+, {(arene)Ru}2+ or {(dppe)Ni}2+ fragments affords the first examples of 4,1,10-MC2B10 species; thermolysis of these yields the appropriate 4,1,12-MC2B10 isomers, unavailable for (arene)Ru metallacarboranes by similar thermolysis of known 4,1,6-MC2B10 compounds.

Journal Article↗