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Biomedical subjects

Ronald Cornet

Publications and source records attributed to Ronald Cornet.

10 recordsLinked to original sources

Design and implementation of an ICU incident registry.

Due to its complexity intensive care is vulnerable to errors. On the ICU adults of the AMC (Amsterdam, The Netherlands) the available registries used for error reporting did not give insight in the occurrence of unwanted events, and did not lead to preventive measures. Therefore, a new registry has been developed on the basis of a literature study on the various terms and definitions that refer to unintended events, and on the methods to register and monitor them. As this registry intends to provide an overall insight into errors, a neutral term ('incident') -- which does not imply guilt or blame -- has been sought together with a broad definition. The attributes of an incident further describe the unwanted event, but they should not form an impediment for the ICU nurses and physicians to report. The properties of a registry that contribute to making it accessible and user friendly have been determined. This has resulted in an electronic registry where incidents can be reported rapidly, voluntarily, anonymously and free of legal consequences. Evaluation is required to see if the new registry indeed provides the ICU management with the intended information on the current situation on incidents. For further refinement of the design, additional development and adjustments are required. However, we expect that the awareness of errors of the ICU personnel has already improved, forming the first step to increased patient safety.

Documentation↗

Description logic-based methods for auditing frame-based medical terminological systems.

OBJECTIVE: Medical terminological systems (TSs) play an increasingly important role in health care by supporting recording, retrieval and analysis of patient information. As the size and complexity of TSs are growing, the need arises for means to audit them, i.e. verify and maintain (logical) consistency and (semantic) correctness of their contents. This is not only important for the management of TSs but also for providing their users with confidence about the reliability of their contents. Formal methods have the potential to play an important role in the audit of TSs, although there are few empirical studies to assess the benefits of using these methods. METHODS AND MATERIAL: In this paper we propose a method based on description logics (DLs) for the audit of TSs. This method is based on the migration of the medical TS from a frame-based representation to a DL-based one. Our method is characterized by a process in which initially stringent assumptions are made about concept definitions. The assumptions allow the detection of concepts and relations that might comprise a source of logical inconsistency. If the assumptions hold then definitions are to be altered to eliminate the inconsistency, otherwise the assumptions are revised. RESULTS: In order to demonstrate the utility of the approach in a real-world case study we audit a TS in the intensive care domain and discuss decisions pertaining to building DL-based representations. This case study demonstrates that certain types of inconsistencies can indeed be detected by applying the method to a medical terminological system. CONCLUSION: The added value of the method described in this paper is that it provides a means to evaluate the compliance to a number of common modeling principles in a formal manner. The proposed method reveals potential modeling inconsistencies, helping to audit and (if possible) improve the medical TS. In this way, it contributes to providing confidence in the contents of the terminological system.

Algorithms↗

Design and implementation of an ICU incident registry.

Due to its complexity intensive care is vulnerable to errors. On the ICU Adults of the AMC (Amsterdam, the Netherlands) the available registries used for error reporting did not give insight in the occurrence of unwanted events, and did not lead to preventive measures. Therefore, a new registry has been developed on the basis of a literature study on the various terms and definitions that refer to unintended events, and on the methods to register and monitor them. As this registry intends to provide an overall insight into errors, a neutral term ('incident') -which does not imply guilt or blame- has been sought together with a broad definition. The attributes of an incident further describe the unwanted event, but they should not form an impediment for the ICU nurses and physicians to report. The properties of a registry that contribute to making it accessible and user friendly have been determined. This has resulted in an electronic registry where incidents can be reported rapidly, voluntarily, anonymously and free of legal consequences. Evaluation is required to see if the new registry indeed provides the ICU management with the intended information on the current situation on incidents. For further refinement of the design, additional development and adjustments are required. However, we expect that the awareness of errors of the ICU personnel has already improved, forming the first step to increased patient safety.

Critical Care↗

Terminological system maintenance: a procedures framework and an exploration of current practice.

The use of electronically stored data requires that the data is recorded in a structured and standardized manner. This has led to the development of terminological systems. The content of these medical terminological systems is subject to continuing changes as a consequence of the developments in the field of medicine.By means of a literature study criteria were obtained for the maintenance of terminological systems. The criteria are used to develop a framework for the management of the maintenance process. The current practice of terminology maintenance was explored in a survey of twenty-seven organizations that currently maintain a terminological system. The results of the survey reveal the diversity and suboptimality of the current maintenance processes. The framework for the management of the maintenance process can be used to eliminate deficiencies in this process. This framework for terminology maintenance is an important step towards standardization of the maintenance of medical terminological systems.

Disease Management↗

Two DL-based methods for auditing medical terminological systems.

Medical terminological systems (TSs) play an increasingly important role in health care by supporting recording, retrieval and analysis of patient information. As the size and complexity of TSs are growing, the need arises for means to audit them, i.e. verify and maintain (logical) consistency and (semantic) correctness of their contents. In this paper we describe two methods based on description logics (DLs) for the audit of TSs. One method uses non-primitive definitions to detect concepts with equivalent definitions. The other method is characterized by stringent assumptions that are made about concept definitions, in order to detect inconsistent definitions. We discuss the possibility of applying these methods to the Foundational Model of Anatomy (FMA) to demonstrate the potentials and pitfalls of these methods. We show that the methods are complementary, and can indeed improve the contents of medical TSs.

Anatomy↗

The specification of a frame-based medical terminological system in Protégé.

A medical terminological system (TS) is essentially a representation of concepts, attributes and relationships pertaining to medical terms. Although the requirements and structures of TSs have enjoyed some attention in the literature, the actual implementation of TSs consisted so far of ad-hoc approaches starting from scratch. Recently, Protégé has been suggested as a software environment for the development of knowledge-based systems. In Protégé various component types interact, and knowledge can be represented at various levels. This paper investigates how to specify a frame-based TS in Protégé and demonstrates this in a specific application in the intensive care. Our approach is characterized by the utilization of a conceptual framework for understanding TSs and mapping its components onto Protégé constructs. This results in specifications of knowledge components for the implementation of terminological systems. The significance of the work stems from the generality of the specifications, thus facilitating the principled design and development of terminological systems in various medical domains

Artificial Intelligence↗

Logical support for terminological modeling.

Terminological modeling, in particular in medical domains, is difficult and has enjoyed growing attention over the recent past. In practice, logical reasoning can play a fundamental role to support the modeling process. Nevertheless, the development of the logical tools is usually driven by computational or theoretical criteria rather than by the direct needs of a modeler. In this paper we attempt to shift this balance and discuss a number of logical reasoning services to support the modeler of a (medical) terminology to construct a formally sound, complete and concise terminology. This modeling support is logical as it is based on reasoning services with respect to formally defined semantics. Practical results of this systematic discussion are formal definitions of several new reasoning tasks.

Information Science↗

Comparison of methods for evaluation of a medical terminological system.

The importance of terminological systems (TS) to support standardized and structured documentation of medical data is commonly recognized. The usability of TS in real practice strongly depends on the completeness and the correctness of the content of the TS. We here present four different methods that can be applied to evaluate a TS' content. All four methods were applied in a case study. We make a comparison of 1) the results of two methods that focus on the completeness of the content and that differ in the application of the TS that they focus on and 2) the results of an automated and a manual evaluation of the correctness of the content. Finally we summarize the results of all four methods and analyze whether they overlap or complement each other.

Critical Care↗

Overcoming barriers to evaluation of terminological systems.

Evaluation of terminological systems has been demonstrated to be a complicated task. This is due to the broad range of terminological systems, their application, and the clinical contexts in which they can be applied. We propose an evaluation framework that explicitly distinguishes an application-independent description of terminological systems, methods to determine application-dependent requirements, and methods to assess the applicability. In order to support a systematic application-independent description of terminological systems, we present a categorization of characteristics, including explicit questions. The answers to these questions can be mapped to the requirements for a certain application of a terminological system. This framework aims at reducing the efforts for determining which terminological system is applicable for a certain clinical setting.

Evaluation Studies as Topic↗

Evaluation of a frame-based ontology: a formalization-oriented approach.

This paper describes the evaluation of our current frame-based ontology in Intensive Care. Our approach to the evaluation consists of formalizing the ontology. The motivation for formalization is twofold: a. The formalization process itself can shed light on the implicit ambiguities in the ontology and b. The result of this process is a representation that facilitates automatic inference. The evaluation has revealed various ambiguities in the current ontology, and has clarified the path for migration towards a formal representation supporting automatic inference.

Critical Care↗