Ronea Harris-Stith | PubMed Health

PubMed2003

Bullous eruption: a manifestation of lupus erythematosus.

Bullous lupus erythematosus (BSLE) is a rare subset of systemic lupus erythematosus (SLE), often associated with autoimmunity to type VII collagen. Generally, patients with BSLE meet the criteria for SLE as defined by the American College of Rheumatology. We present a case of a 17-year-old adolescent girl who presented with a vesiculobullous eruption without detectable type VII collagen antibodies and without full criteria for SLE. Differential staining was characteristic for lupus erythematosus (LE), suggesting her eruption is related to LE. We review the spectrum of bullous disease in patients with LE and discuss the pathogenesis and histology of these eruptions, as well as current therapeutic options.

Adolescent↗

PubMed2002

Tuberous sclerosis.

Tuberous sclerosis (TS) is an autosomal dominant disorder with a significant range of clinical expression. Renal, pulmonary, central nervous system, and cardiac complications may result in severe morbidity. Early recognition of the syndrome is important to ensure prompt identification of systemic involvement. We review the clinical features of tuberous sclerosis and discuss recent advances in our understanding of its pathogenesis and appropriate management.

Adult↗