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Biomedical subjects

Rosemary Reid

Publications and source records attributed to Rosemary Reid.

3 recordsLinked to original sources

Postpartum curettage: an audit of 200 cases.

AIM: To assess whether delivery details, clinical features at presentation and laboratory investigations could accurately predict the presence of retained products of conception (RPOC) following a postpartum curettage (PPC) and to assess the morbidity associated with this procedure. METHODS: A retrospective chart review of patients who underwent a PPC at a tertiary referral hospital over a 5-year period. RESULTS: Two hundred patients were included in the study and 50% of patients who had histological evaluation demonstrated retained product of conception. Mode of delivery, placental status at delivery and immediate postpartum haemorrhage was unrelated to final histology however, patients presenting with pelvic infection were significantly less likely to have RPOC, chi(2 )= 6.358 (P = 0.042). The sensitivity and specificity of ultrasound in detecting RPOC was 94% and 16%, respectively; the presence of an echogenic focus together with a thickened endometrium of more than 10 mm was the most accurate ultrasound feature of RPOC (positive predictive value 80%). Seventeen (8.5%) patients experienced major morbidity following curettage and 14 (7%) underwent a repeat procedure with further morbidity. Patients presenting with pelvic infection were more likely to experience postoperative morbidity. CONCLUSION: A PPC has a low diagnostic yield and is associated with a significant complication rate. While the therapeutic benefit of this procedure is unclear, expectant management is appropriate especially in the presence of pelvic sepsis.

Adolescent↗

Plasma corticotropin-releasing hormone and unconjugated estriol in human pregnancy: gestational patterns and ability to predict preterm delivery.

OBJECTIVE: The purpose of this study was to compare the patterns and timing of the increases in plasma levels of corticotropin-releasing hormone and unconjugated estriol during human pregnancy. STUDY DESIGN: Corticotropin-releasing hormone and unconjugated estriol were measured in serial samples that were collected from preterm subjects and from spontaneous term control subjects who were selected randomly from a study cohort of 297 women. RESULTS: Gestational increases in log corticotropin-releasing hormone and log unconjugated estriol concentrations were best described by linear and cubic polynomial functions, respectively. Plasma unconjugated estriol levels were similar in preterm and term singleton pregnancies at equivalent gestation, whereas corticotropin-releasing hormone was elevated earlier in premature subjects. Mean corticotropin-releasing hormone levels relative to term control subjects (n = 40 women) were shifted forward 16.5 +/- 8.1 days (P =.027, singleton preterm, spontaneous labor; n = 16) and 33.0 +/- 7.9 days (P <.001, singleton preterm, obstetric intervention; n = 10). The corresponding shifts in unconjugated estriol values were -3.8 +/- 2.0 days and -2.7 +/- 5.6 days (both not significant). The prematurity of delivery showed a significant regression on shifts in corticotropin-releasing hormone (P =.004 and P <.001) but not in unconjugated estriol for the 2 groups. The ability to predict prematurity was not significantly improved by regression on corticotropin-releasing hormone and unconjugated estriol shift values together. CONCLUSION: The patterns and timing of gestational changes in corticotropin-releasing hormone and unconjugated estriol differ in humans. The usefulness of corticotropin-releasing hormone as a biochemical preterm marker in singleton pregnancies is not enhanced by the additional measurement of plasma unconjugated estriol.

Corticotropin-Releasing Hormone↗